Zobrazeno 1 - 10
of 389
pro vyhledávání: '"Quentin M Anstee"'
Autor:
Jesús Funuyet-Salas, Agustín Martín-Rodríguez, María Ángeles Pérez-San-Gregorio, Luke Vale, Tomos Robinson, Quentin M Anstee, Manuel Romero-Gómez
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0300362 (2024)
BackgroundIt is unclear what biopsychosocial factors influence the impact of NAFLD on health-related quality of life (HRQoL), and if these factors are equally important predictors between different nationalities.MethodsHRQoL (CLDQ) was measured in bo
Externí odkaz:
https://doaj.org/article/539503160996469980833a51f4ea298b
Autor:
Matthew McTeer, Douglas Applegate, Peter Mesenbrink, Vlad Ratziu, Jörn M Schattenberg, Elisabetta Bugianesi, Andreas Geier, Manuel Romero Gomez, Jean-Francois Dufour, Mattias Ekstedt, Sven Francque, Hannele Yki-Jarvinen, Michael Allison, Luca Valenti, Luca Miele, Michael Pavlides, Jeremy Cobbold, Georgios Papatheodoridis, Adriaan G Holleboom, Dina Tiniakos, Clifford Brass, Quentin M Anstee, Paolo Missier, LITMUS Consortium investigators
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0299487 (2024)
AimsMetabolic dysfunction Associated Steatotic Liver Disease (MASLD) outcomes such as MASH (metabolic dysfunction associated steatohepatitis), fibrosis and cirrhosis are ordinarily determined by resource-intensive and invasive biopsies. We aim to sho
Externí odkaz:
https://doaj.org/article/67ecf06493dd4d75bdee07628520f62d
Autor:
Helen L Reeves, Tim Hoare, Steven Masson, Paul Turner, Lucy Walker, Quentin M Anstee, Stuart McPherson, Mhairi Donnelly, Preya Patel, Beate Haugk, Antony Darne, John Scott, Robyn Watson, Jessica Dyson, Steven White, Gourab Sen, Sanjay Pandanaboyana, John Hammond, Stuart Robinson, Jeremy J French, Mark Hudson, Kirsty Anderson, Derek M Manas, Peter Littler, Daniel Geh, Misti McCain, Alastair Burt, Louise MacDougal, Michael McNeil, Nick Wadd, Syed Asghar, Lavanya Mariappan, Jane Margetts, Yvonne Bury, Shreya Raman, Daniel Parkinson, Benjamin Stenberg
Publikováno v:
BMJ Open Gastroenterology, Vol 9, Iss 1 (2022)
Background Northern England has been experiencing a persistent rise in the number of primary liver cancers, largely driven by an increasing incidence of hepatocellular carcinoma (HCC) secondary to alcohol-related liver disease and non-alcoholic fatty
Externí odkaz:
https://doaj.org/article/93c4d1073c934cc8b0678fe34c3b162f
Autor:
Douglas S Lee, Atsushi Nakajima, Quentin M Anstee, Frank Tacke, Vincent Wai-Sun Wong, Naim Alkhouri, Neeta B Amin, Amanda Darekar, Manoli Vourvahis, Michael Charlton, Carla Yunis
Publikováno v:
BMJ Open, Vol 12, Iss 3 (2022)
Introduction Small molecule inhibitors of the terminal step in intrahepatic triglyceride synthesis (diacylglycerol acyltransferase 2 inhibitor (DGAT2i, PF-06865571, ervogastat)) and upstream blockade of de novo lipogenesis via acetyl-coenzyme A carbo
Externí odkaz:
https://doaj.org/article/f6f8ea7c39c046299eb38f3562ecfc5c
Publikováno v:
BMJ Open, Vol 11, Iss 4 (2021)
Introduction Lifestyle interventions targeting weight loss and improved dietary patterns are the recommended treatment for non-alcoholic fatty liver disease (NAFLD). However, the effectiveness of current established diet therapies is suboptimal. The
Externí odkaz:
https://doaj.org/article/bd5d6d91d72f4c0aae63cefb8b821384
Autor:
Helen Jarvis, Dawn Craig, Robert Barker, Gemma Spiers, Daniel Stow, Quentin M Anstee, Barbara Hanratty
Publikováno v:
PLoS Medicine, Vol 17, Iss 4, p e1003100 (2020)
BackgroundNon-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease worldwide. Many individuals have risk factors associated with NAFLD, but the majority do not develop advanced liver disease: cirrhosis, hepatic decompensa
Externí odkaz:
https://doaj.org/article/91933fd01dad440d99649c4f4a62f11b
Autor:
Jenny Lee, Yasaman Vali, Jérôme Boursier, Kevin Duffin, Joanne Verheij, M Julia Brosnan, Koos Zwinderman, Quentin M Anstee, Patrick M Bossuyt, Mohammad Hadi Zafarmand
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238717 (2020)
IntroductionAssociation between elevated cytokeratin 18 (CK-18) levels and hepatocyte death has made circulating CK-18 a candidate biomarker to differentiate non-alcoholic fatty liver from non-alcoholic steatohepatitis (NASH). Yet studies produced va
Externí odkaz:
https://doaj.org/article/2f307106f67c4f1e9fdc27dd23d18588
Autor:
Stuart McPherson, Nina Wilkinson, Dina Tiniakos, Jennifer Wilkinson, Alastair D Burt, Elaine McColl, Deborah D Stocken, Nick Steen, Jane Barnes, Nicola Goudie, Stephen Stewart, Yvonne Bury, Derek Mann, Quentin M Anstee, Christopher P Day
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175717 (2017)
INTRODUCTION:Non-alcoholic fatty liver disease (NAFLD) is a common liver disease worldwide. Experimental and small clinical trials have demonstrated that angiotensin II blockers (ARB) may be anti-fibrotic in the liver. The aim of this randomised cont
Externí odkaz:
https://doaj.org/article/b338d05dc43343f1b0265870bb848d7b
Autor:
Michelle Goldsworthy, Nathan L Absalom, David Schröter, Helen C Matthews, Debora Bogani, Lee Moir, Anna Long, Christopher Church, Alison Hugill, Quentin M Anstee, Rob Goldin, Mark Thursz, Florian Hollfelder, Roger D Cox
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e61870 (2013)
We employed a random mutagenesis approach to identify novel monogenic determinants of type 2 diabetes. Here we show that haplo-insufficiency of the histone methyltransferase myeloid-lineage leukemia (Mll2/Wbp7) gene causes type 2 diabetes in the mous
Externí odkaz:
https://doaj.org/article/58b7322445b04143b65c00724e6e8374
Autor:
Partho Sen, Olivier Govaere, Tim Sinioja, Aidan McGlinchey, Dawei Geng, Vlad Ratziu, Elisabetta Bugianesi, Jörn M. Schattenberg, Antonio Vidal-Puig, Michael Allison, Simon Cockell, Ann K. Daly, Tuulia Hyötyläinen, Quentin M. Anstee, Matej Orešič
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104949- (2022)
Summary: Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent disease that is associated with multiple metabolic disturbances, yet the metabolic pathways underlying its progression are poorly understood. Here, we studied metabolic pa
Externí odkaz:
https://doaj.org/article/ff48a05fd4c04ac5b4dbc6cdda589a9f