Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes

Autor: Quentin Lachaud, Muhamad Hifzhudin Noor Aziz, Francis L Burton, Niall Macquaide, Rachel C Myles, Radostin D Simitev, Godfrey L Smith

Publikováno v: Cardiovascular Research. 118:3112-3125

Aims Cardiac electrophysiological heterogeneity includes: (i) regional differences in action potential (AP) waveform, (ii) AP waveform differences in cells isolated from a single region, (iii) variability of the contribution of individual ion current

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170d4a6dcfc49ffa4293fc994e9b5c19
https://doi.org/10.1093/cvr/cvab375

Versatile open software to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo

Autor: Godfrey L. Smith, Ingra Mannhardt, Richard P. Davis, Sarah M. Kamel, Chris Denning, Christine L. Mummery, Thomas Eschenhagen, Eduard R. Holman, Elisa Giacomelli, Michel A.E. Dieben, Catarina Grandela, Robert Passier, Charlotte D. Koopman, Jeroen Bakkers, Mervyn P.H. Mol, Arne Hansen, Valeria V. Orlova, Leon G.J. Tertoolen, Milena Bellin, Quentin Lachaud, Monique R.M. Jongbloed, Luca Sala, Marcelo C. Ribeiro, Francis L. Burton, Berend J. van Meer, Umber Saleem

Contraction of muscle reflects its physiological state. Methods to quantify contraction are often complex, expensive and tailored to specific models or recording conditions, or require specialist knowledge for data extraction. Here we describe an aut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36167cf56cac4966d506e57889aa6547
https://doi.org/10.1101/160754

Musclemotion : A versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo

Autor: Michel A.E. Dieben, Christine L. Mummery, Umber Saleem, Arne Hansen, Mervyn P.H. Mol, Marcelo C. Ribeiro, Francis L. Burton, Berend J. van Meer, Robert Passier, Elisa Giacomelli, Valeria V. Orlova, Eduard R. Holman, Catarina Grandela, Charlotte D. Koopman, Richard P. Davis, Diogo Mosqueira, Luca Sala, Quentin Lachaud, Leon G.J. Tertoolen, Monique R.M. Jongbloed, Jeroen Bakkers, Milena Bellin, Ingra Mannhardt, Sarah M. Kamel, Chris Denning, Thomas Eschenhagen, Godfrey L. Smith

Publikováno v: Circulation Research
Circulation Research, 122(3), e5. Lippincott Williams and Wilkins
Circulation research, 122(3), e5-e16. Lippincott Williams & Wilkins
Circulation Research. Lippincott Williams & Wilkins
Circulation Research, 122(3), e5-e16

Rationale: There are several methods to measure cardiomyocyte and muscle contraction, but these require customized hardware, expensive apparatus, and advanced informatics or can only be used in single experimental models. Consequently, data and techn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4b12a8ac9e8b322216690a678650b8
https://doi.org/10.1161/circresaha.117.312067