Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Quentin Kaas"'
Autor:
Junqiao Du, Kuok Yap, Lai Yue Chan, Fabian B. H. Rehm, Fong Yang Looi, Aaron G. Poth, Edward K. Gilding, Quentin Kaas, Thomas Durek, David J. Craik
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Asparaginyl endopeptidases (AEPs) catalyze the cyclization step during the biosynthesis of cyclic peptides in plants. Here, the authors report a recombinantly produced AEP that catalyzes the backbone cyclization of a linear cyclotide precursor and an
Externí odkaz:
https://doaj.org/article/2374d960c8e2417095bdec822494ebdd
Publikováno v:
Marine Drugs, Vol 21, Iss 3, p 154 (2023)
The venom of marine cone snails is mainly composed of peptide toxins called conopeptides, among which conotoxins represent those that are disulfide-rich. Publications on conopeptides frequently state that conopeptides attract considerable interest fo
Externí odkaz:
https://doaj.org/article/6ed8324f1c3040fc9d49d653d6ecb2fd
Publikováno v:
Marine Drugs, Vol 19, Iss 9, p 482 (2021)
The α4β2 nAChR is implicated in a range of diseases and disorders including nicotine addiction, epilepsy and Parkinson’s and Alzheimer’s diseases. Designing α4β2 nAChR selective inhibitors could help define the role of the α4β2 nAChR in suc
Externí odkaz:
https://doaj.org/article/5fcb53a97c2f4c5c80ad2a6663dea515
Autor:
Nargis Tabassum, Han-Shen Tae, Xinying Jia, Quentin Kaas, Tao Jiang, David J. Adams, Rilei Yu
Publikováno v:
ACS Omega, Vol 2, Iss 8, Pp 4621-4631 (2017)
Externí odkaz:
https://doaj.org/article/53f75fd9e7da49caa2093e8ea6a3307a
Autor:
Yamina El Hamdaoui, Xiaosa Wu, Richard J. Clark, Julien Giribaldi, Raveendra Anangi, David J. Craik, Glenn F. King, Sebastien Dutertre, Quentin Kaas, Volker Herzig, Annette Nicke
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Peptides derived from animal venoms provide important research tools for biochemical and pharmacological characterization of receptors, ion channels, and transporters. Some venom peptides have been developed into drugs (such as the synthetic ω-conot
Externí odkaz:
https://doaj.org/article/eacd1d7b24de4b5081dc50b6a46c3144
Autor:
Quentin Kaas, David J. Craik
Publikováno v:
Toxins, Vol 7, Iss 6, Pp 2159-2187 (2015)
Venomics is a modern approach that combines transcriptomics and proteomics to explore the toxin content of venoms. This review will give an overview of computational approaches that have been created to classify and consolidate venomics data, as well
Externí odkaz:
https://doaj.org/article/2a7e48c2dc1b4b1ba3a353dc4d9663a5
Publikováno v:
Marine Drugs, Vol 16, Iss 4, p 118 (2018)
A diverse range of predatory marine gastropods produce toxins, yet most of these molecules remain uncharacterized. Conus species have received the most attention from researchers, leading to several conopeptides reaching clinical trials. This review
Externí odkaz:
https://doaj.org/article/3b55a64e1981415a851df355d71e7736
Autor:
Paola G. Ojeda, David Ramírez, Jans Alzate-Morales, Julio Caballero, Quentin Kaas, Wendy González
Publikováno v:
Toxins, Vol 10, Iss 1, p 8 (2017)
Most snake venom toxins are proteins, and participate to envenomation through a diverse array of bioactivities, such as bleeding, inflammation, and pain, cytotoxic, cardiotoxic or neurotoxic effects. The venom of a single snake species contains hundr
Externí odkaz:
https://doaj.org/article/2e6efb811d15409d8124d0d0f308d3fc
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 3, p e1002011 (2011)
α-Conotoxins potently inhibit isoforms of nicotinic acetylcholine receptors (nAChRs), which are essential for neuronal and neuromuscular transmission. They are also used as neurochemical tools to study nAChR physiology and are being evaluated as dru
Externí odkaz:
https://doaj.org/article/e11921e0e7f943bbab70766ffe977b37
Autor:
Xiaopeng Zhu, Shuai Wang, Quentin Kaas, Jinpeng Yu, Yong Wu, Peta J. Harvey, Dongting Zhangsun, David J. Craik, Sulan Luo
Publikováno v:
Journal of Medicinal Chemistry. 66:2020-2031