Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Quentin Kaas"'
Autor:
Junqiao Du, Kuok Yap, Lai Yue Chan, Fabian B. H. Rehm, Fong Yang Looi, Aaron G. Poth, Edward K. Gilding, Quentin Kaas, Thomas Durek, David J. Craik
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Asparaginyl endopeptidases (AEPs) catalyze the cyclization step during the biosynthesis of cyclic peptides in plants. Here, the authors report a recombinantly produced AEP that catalyzes the backbone cyclization of a linear cyclotide precursor and an
Externí odkaz:
https://doaj.org/article/2374d960c8e2417095bdec822494ebdd
Publikováno v:
Marine Drugs, Vol 21, Iss 3, p 154 (2023)
The venom of marine cone snails is mainly composed of peptide toxins called conopeptides, among which conotoxins represent those that are disulfide-rich. Publications on conopeptides frequently state that conopeptides attract considerable interest fo
Externí odkaz:
https://doaj.org/article/6ed8324f1c3040fc9d49d653d6ecb2fd
Autor:
Xiaopeng Zhu, Shuai Wang, Quentin Kaas, Jinpeng Yu, Yong Wu, Peta J. Harvey, Dongting Zhangsun, David J. Craik, Sulan Luo
Publikováno v:
Journal of Medicinal Chemistry. 66:2020-2031
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59159b461ecbb1ebaa3c347ca496081c
https://doi.org/10.1021/acs.jmedchem.2c01786
https://doi.org/10.1021/acs.jmedchem.2c01786
Publikováno v:
Marine Drugs, Vol 19, Iss 9, p 482 (2021)
The α4β2 nAChR is implicated in a range of diseases and disorders including nicotine addiction, epilepsy and Parkinson’s and Alzheimer’s diseases. Designing α4β2 nAChR selective inhibitors could help define the role of the α4β2 nAChR in suc
Externí odkaz:
https://doaj.org/article/5fcb53a97c2f4c5c80ad2a6663dea515
Autor:
Nargis Tabassum, Han-Shen Tae, Xinying Jia, Quentin Kaas, Tao Jiang, David J. Adams, Rilei Yu
Publikováno v:
ACS Omega, Vol 2, Iss 8, Pp 4621-4631 (2017)
Externí odkaz:
https://doaj.org/article/53f75fd9e7da49caa2093e8ea6a3307a
Autor:
Yamina El Hamdaoui, Xiaosa Wu, Richard J. Clark, Julien Giribaldi, Raveendra Anangi, David J. Craik, Glenn F. King, Sebastien Dutertre, Quentin Kaas, Volker Herzig, Annette Nicke
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Peptides derived from animal venoms provide important research tools for biochemical and pharmacological characterization of receptors, ion channels, and transporters. Some venom peptides have been developed into drugs (such as the synthetic ω-conot
Externí odkaz:
https://doaj.org/article/eacd1d7b24de4b5081dc50b6a46c3144
Autor:
Quentin Kaas, David J. Craik
Publikováno v:
Toxins, Vol 7, Iss 6, Pp 2159-2187 (2015)
Venomics is a modern approach that combines transcriptomics and proteomics to explore the toxin content of venoms. This review will give an overview of computational approaches that have been created to classify and consolidate venomics data, as well
Externí odkaz:
https://doaj.org/article/2a7e48c2dc1b4b1ba3a353dc4d9663a5
Autor:
Ferran Nadal-Bufí, Lai Y. Chan, Hadi H. Mohammad, Jody M. Mason, Carlos Salomon, Andrew Lai, Erik W. Thompson, David J. Craik, Quentin Kaas, Sónia T. Henriques
Publikováno v:
Cellular and Molecular Life Sciences. 79
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43d8251c2b95a661309d07f484b16c34
https://doi.org/10.1007/s00018-022-04633-3
https://doi.org/10.1007/s00018-022-04633-3
Autor:
Andrew M. White, Anita Dellsén, Niklas Larsson, Quentin Kaas, Frank Jansen, Alleyn T. Plowright, Laurent Knerr, Thomas Durek, David J. Craik
Publikováno v:
Journal of medicinal chemistry. 65(19)
In this work, cysteine staples were used as a late-stage functionalization strategy to diversify peptides and build conjugates targeting the melanocortin G-protein-coupled receptors [melanocortin receptor-1 (MC1R) and MC3R-MC5R]. Monocyclic and bicyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a1ebcd561d0e46c4a7118ee9206de1
https://pubmed.ncbi.nlm.nih.gov/36167503
https://pubmed.ncbi.nlm.nih.gov/36167503
Autor:
Simon J. de Veer, Udo Bauer, Olivier Cheneval, Abdullah A. H. Ahmad Fuaad, Christina I. Schroeder, Niklas Larsson, Laurent Knerr, Joachim Weidmann, Anita Dellsén, David J. Craik, Thomas Durek, Torben Østerlund, Andrew M. White, Alleyn T. Plowright, Quentin Kaas
Publikováno v:
Journal of Medicinal Chemistry. 64:9906-9915
We have designed a new class of highly potent bivalent melanocortin receptor ligands based on the nature-derived bicyclic peptide sunflower trypsin inhibitor 1 (SFTI-1). Incorporation of melanotropin pharmacophores in each of the two turn regions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ff35b0edf3cf0759a43fd048230777
https://doi.org/10.1021/acs.jmedchem.1c00095
https://doi.org/10.1021/acs.jmedchem.1c00095