Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Quentin J. Mccubbin"'
Autor:
Erin O’Brien, Frederick Hicks, Matt Stirling, Quentin J. McCubbin, Lei Zhu, Ashley McCarron, Eric L. Elliott, Ian Armitage, Marianne Langston
Publikováno v:
Organic Process Research & Development. 19:1299-1307
A practical synthesis of a novel NEDD8-activating enzyme (NAE) inhibitor pevonedistat (MLN4924) is described. Key steps include an enantioselective synthesis of an amino-diol cyclopentane intermediate containing three chiral centers and a novel, regi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b993e38701133292aca68c4fcf27183e
https://doi.org/10.1021/acs.oprd.5b00209
https://doi.org/10.1021/acs.oprd.5b00209
Autor:
Louis Plamondon, Magnus Ronn, Quentin J. Mccubbin, Neil Grimster, Tony Alorati, Melanie K. Veige, Steve Winter
Publikováno v:
Organic Process Research & Development. 11:241-245
An expedient synthesis of MLN1251 has been developed that allows for the production of multikilogram quantities of the target compound. The key transformation is synthesis of a 5-hydroxyindole by a Nenitzescu reaction. The longest linear sequence is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70acdb0e2dc213346a476a60fce25f0a
https://doi.org/10.1021/op060245h
https://doi.org/10.1021/op060245h