Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Quentin I Churches"'
Autor:
Carol J Hartley, Nigel G French, Judith A Scoble, Charlotte C Williams, Quentin I Churches, Andrew R Frazer, Matthew C Taylor, Greg Coia, Gregory Simpson, Nicholas J Turner, Colin Scott
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0184183 (2017)
Carbon-carbon bond formation is one of the most challenging reactions in synthetic organic chemistry, and aldol reactions catalysed by dihydroxyacetone phosphate-dependent aldolases provide a powerful biocatalytic tool for combining C-C bond formatio
Externí odkaz:
https://doaj.org/article/4d4fe9d0740a4dc786c6939cfa0827f8
Autor:
Greg Coia, Quentin I. Churches, Charlotte C. Williams, Andrew C. Warden, Nicholas J. Turner, Chantel N. Jensen, Greg Simpson, Andrew R. Frazer, Tom Nebl, Carol J. Hartley, Judith A. Scoble, Colin Scott, Nigel G. French, Andrea North
Publikováno v:
Nature Catalysis. 2:1006-1015
Biocatalysis is an attractive route for the synthesis of complex organic molecules, such as pharmaceuticals, due to the properties of enzymes (high specificity and high catalytic rate). Ideally, we would be able to use enzymes in continuous-flow reac
Autor:
Judith A. Scoble, Carol J. Hartley, Gregory W. Simpson, Colin Scott, Matthew C. Taylor, Quentin I. Churches, Andrew R. Frazer, Nicholas J. Turner, Greg Coia, Charlotte C. Williams, Nigel G. French
Publikováno v:
PLoS ONE
Hartley, C J, French, N G, Scoble, J A, Williams, C C, Churches, Q I, Frazer, A R, Taylor, M C, Coia, G, Simpson, G, Turner, N J & Scott, C 2017, ' Sugar analog synthesis by in vitro biocatalytic cascade : A comparison of alternative enzyme complements for dihydroxyacetone phosphate production as a precursor to rare chiral sugar synthesis ', PLoS ONE, vol. 12, no. 11, e0184183 . https://doi.org/10.1371/journal.pone.0184183
PLoS ONE, Vol 12, Iss 11, p e0184183 (2017)
Hartley, C J, French, N G, Scoble, J A, Williams, C C, Churches, Q I, Frazer, A R, Taylor, M C, Coia, G, Simpson, G, Turner, N J & Scott, C 2017, ' Sugar analog synthesis by in vitro biocatalytic cascade : A comparison of alternative enzyme complements for dihydroxyacetone phosphate production as a precursor to rare chiral sugar synthesis ', PLoS ONE, vol. 12, no. 11, e0184183 . https://doi.org/10.1371/journal.pone.0184183
PLoS ONE, Vol 12, Iss 11, p e0184183 (2017)
Carbon-carbon bond formation is one of the most challenging reactions in synthetic organic chemistry, and aldol reactions catalysed by dihydroxyacetone phosphate-dependent aldolases provide a powerful biocatalytic tool for combining C-C bond formatio
Autor:
Victor A. Streltsov, Paul A. Adlard, Martin D. de Jonge, Ian Birchall, Simon James, Dominic J. Hare, Quentin I. Churches, Gawain McColl
Publikováno v:
ACS chemical neuroscience. 8(3)
The metal ions of iron, copper, and zinc have long been associated with the aggregation of β-amyloid (Aβ) plaques in Alzheimer's disease; an interaction that has been suggested to promote increased oxidative stress and neuronal dysfunction. We exam
Autor:
Adiel Coca, Heather DeFrancesco, Joshua Dudley, Manabu Hatano, Kazuaki Ishihara, Subash C. Jonnalagadda, Pathi Suman, Amardeep Patel, Gayathri Jampana, Alexander Colfer, Atsushi Abiko, Donald S. Matteson, Stephen J. Geier, Christopher M. Vogels, Stephen A. Westcott, Andrew G. Karatjas, Heidi A. McBriarty, Stephan I. Braye, David Piscitelli, Shinichi Itsuno, Cessandra A. Guerrera, Todd R. Ryder, Astha Verma, Webster L. Santos, Quentin I. Churches, Craig A. Hutton, John J. Molloy, Allan J. B. Watson, Liang Xu, Shuai Zhang, Pengfei Li, Manoj Mondal, Utpal Bora, Chun-Young Lee, Cheol-Hong Cheon
Autor:
Chad K. Heazlewood, Susan K. Nilsson, Brenda Williams, Quentin I. Churches, Jochen Grassinger, Songhui Li, Zhen Zhang, Simon James, Benjamin Cao, Thalia Papayannopoulou
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The inherent disadvantages of using granulocyte colony-stimulating factor (G-CSF) for hematopoietic stem cell (HSC) mobilization have driven efforts to identify alternate strategies based on single doses of small molecules. Here, we show targeting α
Autor:
A. L. Brown, Luke Hunter, Craig A. Hutton, Scott B. Cohen, Philip Wai Hong Chan, Nathan L. Fifer, Quentin I. Churches
This account describes the total synthesis of ustiloxin D. A first-generation, chiral pool approach to the functionalized isoleucine precursor was unsuccessful but yielded several interesting observations. A revised strategy was devised in which the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c2482c9a0c8b2e4d52b7ced2385f45d
https://doi.org/10.1016/b978-0-08-100756-3.00006-6
https://doi.org/10.1016/b978-0-08-100756-3.00006-6
Autor:
Quentin I. Churches, Craig A. Hutton
Publikováno v:
Boron Reagents in Synthesis ISBN: 9780841231832
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fa35ed0ee51d3c334c2acaf693a6de7
https://doi.org/10.1021/bk-2016-1236.ch011
https://doi.org/10.1021/bk-2016-1236.ch011
Publikováno v:
Organic Letters. 13:2900-2903
Petasis reactions of substituted styrenylboronic acids and glyoxylic acid, employing tert-butylsulfinamide as the 'amine' component, proceed with high stereoselectivity to produce β,γ-dehydrohomoarylalanine derivatives. Subsequent asymmetric dihydr
Autor:
Scott B. Cohen, Craig A. Hutton, Helen E. Stewart, Adam Shröder, Peter Turner, Quentin I. Churches
Publikováno v:
Pure and Applied Chemistry. 80:687-694
Several chiral amines were investigated for the stereoselective preparation of homophenylalanine derivatives using the Petasis reaction. Chiral secondary amines such as N,α-dimethylbenzylamine and N-benzylphenylglycinol gave the best results in term