Multi-site tumor sampling highlights molecular intra-tumor heterogeneity in malignant pleural mesothelioma

Autor: Clément Meiller, François Montagne, Theo Z. Hirsch, Stefano Caruso, Julien de Wolf, Quentin Bayard, Jean-Baptiste Assié, Léa Meunier, Yuna Blum, Lisa Quetel, Laure Gibault, Ecaterina Pintilie, Cécile Badoual, Sarah Humez, Françoise Galateau-Sallé, Marie-Christine Copin, Eric Letouzé, Arnaud Scherpereel, Jessica Zucman-Rossi, Françoise Le Pimpec-Barthes, Marie-Claude Jaurand, Didier Jean

Publikováno v: Genome Medicine, Vol 13, Iss 1, Pp 1-16 (2021)

Abstract Background Malignant pleural mesothelioma (MPM) is a heterogeneous cancer. Better knowledge of molecular and cellular intra-tumor heterogeneity throughout the thoracic cavity is required to develop efficient therapies. This study focuses on

Externí odkaz: https://doaj.org/article/f28dbb2176c54bca878c197186dd3f4f

Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis

Autor: Eric Letouzé, Jayendra Shinde, Victor Renault, Gabrielle Couchy, Jean-Frédéric Blanc, Emmanuel Tubacher, Quentin Bayard, Delphine Bacq, Vincent Meyer, Jérémy Semhoun, Paulette Bioulac-Sage, Sophie Prévôt, Daniel Azoulay, Valérie Paradis, Sandrine Imbeaud, Jean-François Deleuze, Jessica Zucman-Rossi

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Tumorigenesis is a complex process driven by numerous risk factors. Here, genomic analysis of liver cancer reveals the evolution of mutational signatures during tumor development, highlighting mutational and structural signatures linked to environmen

Externí odkaz: https://doaj.org/article/a2db6282c9e94e1b953a8aca7a20d3f7

Data from Integrated Genomic Analysis Identifies Driver Genes and Cisplatin-Resistant Progenitor Phenotype in Pediatric Liver Cancer

Autor: Jessica Zucman-Rossi, Eric Letouzé, Sandra Rebouissou, Laurence Brugières, Catherine Guettier, Sophie Branchereau, Véronique Laithier, Sophie Taque, Isabelle Aerts, Monique Fabre, Florent Guerin, Emmanuel Jacquemin, Emmanuel Gonzales, Christophe Chardot, Brice Fresneau, Jean-François Deleuze, Victor Renault, Stefano Caruso, Léa Meunier, Eric Trépo, Quentin Bayard, Laura Molina, Benedict J.E. Monteiro, Amélie Roehrig, Guillaume Morcrette, Jill Pilet, Theo Z. Hirsch

Pediatric liver cancers (PLC) comprise diverse diseases affecting infants, children, and adolescents. Despite overall good prognosis, PLCs display heterogeneous response to chemotherapy. Integrated genomic analysis of 126 pediatric liver tumors showe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73d82c7dcb81baa0879e48b48f09bede
https://doi.org/10.1158/2159-8290.c.6549043.v1

Structure, Dynamics, and Impact of Replication Stress–Induced Structural Variants in Hepatocellular Carcinoma

Autor: Quentin Bayard, Pierre Cordier, Camille Péneau, Sandrine Imbeaud, Theo Z. Hirsch, Victor Renault, Jean-Charles Nault, Jean-Frédéric Blanc, Julien Calderaro, Chantal Desdouets, Jessica Zucman-Rossi, Eric Letouzé

Publikováno v: Cancer Research
Cancer Research, American Association for Cancer Research, 2022, 82 (8), pp.1470-1481. ⟨10.1158/0008-5472.CAN-21-3665⟩
Cancer Research, 2022, 82 (8), pp.1470-1481. ⟨10.1158/0008-5472.CAN-21-3665⟩

Oncogene activation leads to replication stress and promotes genomic instability. Here we combine optical mapping and whole-genome sequencing (WGS) to explore in depth the nature of structural variants (SV) induced by replication stress in cyclin-act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a592b2955c121f211fc9d610f3d3b4
https://doi.org/10.1158/0008-5472.can-21-3665

Supplementary Data from Structure, Dynamics, and Impact of Replication Stress–Induced Structural Variants in Hepatocellular Carcinoma

Autor: Eric Letouzé, Jessica Zucman-Rossi, Chantal Desdouets, Julien Calderaro, Jean-Frédéric Blanc, Jean-Charles Nault, Victor Renault, Theo Z. Hirsch, Sandrine Imbeaud, Camille Péneau, Pierre Cordier, Quentin Bayard

Supplementary Data from Structure, Dynamics, and Impact of Replication Stress–Induced Structural Variants in Hepatocellular Carcinoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3657e395b7cf7b3dc7b35269728942
https://doi.org/10.1158/0008-5472.22431433