A stimulus‐contingent positive feedback loop enables IFN‐β dose‐dependent activation of pro‐inflammatory genes

Autor: Catera L Wilder, Diane Lefaudeux, Raisa Mathenge, Kensei Kishimoto, Alma Zuniga Munoz, Minh A Nguyen, Aaron S Meyer, Quen J Cheng, Alexander Hoffmann

Publikováno v: Molecular Systems Biology, Vol 19, Iss 5, Pp 1-19 (2023)

Abstract Type I interferons (IFN) induce powerful antiviral and innate immune responses via the transcription factor, IFN‐stimulated gene factor (ISGF3). However, in some pathological contexts, type I IFNs are responsible for exacerbating inflammat

Externí odkaz: https://doaj.org/article/a5383c65692343a1ac5b165b07e6e06b

An NFκB Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NFκB via Distinct Mechanisms

Autor: Simon Mitchell, Ellen L. Mercado, Adewunmi Adelaja, Jessica Q. Ho, Quen J. Cheng, Gourisankar Ghosh, Alexander Hoffmann

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Nuclear factor kappa B (NFκB) is a transcription factor that controls inflammation and cell survival. In clinical histology, elevated NFκB activity is a hallmark of poor prognosis in inflammatory disease and cancer, and may be the result of a combi

Externí odkaz: https://doaj.org/article/e2c67ada706044d395a370f9036e98b5

Sequential conditioning-stimulation reveals distinct gene- and stimulus-specific effects of Type I and II IFN on human macrophage functions

Autor: Rosane M. B. Teles, Alexander Hoffmann, Faraz Behzadi, Quen J. Cheng, Robert L. Modlin, Sho Ohta, Supriya Sen, Roberto Spreafico

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific reports, vol 9, iss 1
Scientific Reports
Cheng, Quen; Behzadi, Faraz; Sen, Supriya; Ohta, Sho; Spreafico, Roberto; Teles, Rosane; et al.(2019). Sequential conditioning-stimulation reveals distinct gene-and stimulus-specific effects of Type I and II IFN on human macrophage functions.. Scientific reports, 9(1), 5288. doi: 10.1038/s41598-019-40503-y. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4fg6d5hc

Macrophages orchestrate immune responses by sensing and responding to pathogen-associated molecules. These responses are modulated by prior conditioning with cytokines such as interferons (IFNs). Type I and II IFN have opposing functions in many biol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d96deacff469a535eea6983ab1fb858
http://link.springer.com/article/10.1038/s41598-019-40503-y

NFκB dynamics determine the stimulus-specificity of epigenomic reprogramming in macrophages

Autor: Brooks Taylor, Katherine M. Sheu, Alexander Hoffmann, Roberto Spreafico, Adewunmi Adelaja, Quen J. Cheng, Sho Ohta

SummaryThe epigenome defines the cell type, but also shows plasticity that enables cells to tune their gene expression potential to the context of extracellular cues. This is evident in immune sentinel cells such as macrophages, which can respond to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aca123f3a51340201d2b5b70848120a

Duodenoscope-Related Outbreak of a Carbapenem-Resistant Klebsiella pneumoniae Identified Using Advanced Molecular Diagnostics

Autor: Peera Hemarajata, Venkatara Raman Muthusamy, Romney M. Humphries, Zachary Rubin, Dana Russell, Daniel Z. Uslan, Alisa M Trout, Quen J. Cheng, Shuan Yang, Teresa Zaroda, Stephen Kim, Grace M. Aldrovandi

Publikováno v: Clinical Infectious Diseases. 65:1159-1166

Background Carbapenem-resistant Klebsiella pneumoniae infections are increasingly prevalent in North American hospitals. We describe an outbreak of carbapenem-resistant K. pneumoniae containing the blaOXA-232 gene transmitted by contaminated duodenos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b1c8ff2b7d3e5f9e37c16e99808ace
https://doi.org/10.1093/cid/cix527