Advanced patient-specific microglia cell models for pre-clinical studies in Alzheimer's disease.

Autor: Cuní-López C; Mental Health and Neuroscience Department, QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia.; Faculty of Medicine, The University of Queensland, Herston, QLD, 4006, Australia., Stewart R; Mental Health and Neuroscience Department, QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia.; UQ Centre for Clinical Research, The University of Queensland, Brisbane City, QLD, 4029, Australia., Oikari LE; Mental Health and Neuroscience Department, QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia.; School of Biomedical Sciences, Queensland University of Technology, Brisbane City, QLD, 4000, Australia., Nguyen TH; Scientific Services, QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia., Roberts TL; UQ Centre for Clinical Research, The University of Queensland, Brisbane City, QLD, 4029, Australia.; Ingham Institute for Applied Medical Research and School of Medicine, Western Sydney University, Liverpool, NSW, 2170, Australia., Sun Y; Mental Health and Neuroscience Department, QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia., Guo CC; Mental Health and Neuroscience Department, QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia.; ActiGraph LLC, Pensacola, FL, 32502, USA., Lupton MK; Mental Health and Neuroscience Department, QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia.; Faculty of Medicine, The University of Queensland, Herston, QLD, 4006, Australia.; School of Biomedical Sciences, Queensland University of Technology, Brisbane City, QLD, 4000, Australia., White AR; Mental Health and Neuroscience Department, QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia. Tony.White@qimrberghofer.edu.au.; Faculty of Medicine, The University of Queensland, Herston, QLD, 4006, Australia. Tony.White@qimrberghofer.edu.au., Quek H; Mental Health and Neuroscience Department, QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia. Hazel.Quek@qimrberghofer.edu.au.; School of Biomedical Sciences, The University of Queensland, Lucia, QLD, 4072, Australia. Hazel.Quek@qimrberghofer.edu.au.; School of Biomedical Sciences, Queensland University of Technology, Brisbane City, QLD, 4000, Australia. Hazel.Quek@qimrberghofer.edu.au.

Publikováno v: Journal of neuroinflammation [J Neuroinflammation] 2024 Feb 15; Vol. 21 (1), pp. 50. Date of Electronic Publication: 2024 Feb 15.

Patient-Derived Blood-Brain Barrier Model for Screening Copper Bis(thiosemicarbazone) Complexes as Potential Therapeutics in Alzheimer's Disease.

Autor: Wasielewska JM; Mental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.; Faculty of Medicine, University of Queensland, Herston, QLD 4006, Australia., Szostak K; School of Chemistry, Bio21 Institute for Molecular Science and Biotechnology, The University of Melbourne, Parkville, VIC 3010, Australia., McInnes LE; School of Chemistry, Bio21 Institute for Molecular Science and Biotechnology, The University of Melbourne, Parkville, VIC 3010, Australia., Quek H; Mental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.; School of Biomedical Science, University of Queensland, St. Lucia, QLD 4067, Australia., Chaves JCS; Mental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD 4000, Australia., Liddell JR; Department of Anatomy and Physiology, The University of Melbourne, Parkville, VIC 3010, Australia., Koistinaho J; Drug Research Program, Division of Pharmacology and Pharmacotherapy, University of Helsinki, Helsinki 00014,Finland.; Neuroscience Centre, Helsinki Institute of Life Science, University of Helsinki, Helsinki 00014, Finland., Oikari LE; Mental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia., Donnelly PS; School of Chemistry, Bio21 Institute for Molecular Science and Biotechnology, The University of Melbourne, Parkville, VIC 3010, Australia., White AR; Mental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.; School of Biomedical Science, University of Queensland, St. Lucia, QLD 4067, Australia.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2024 Apr 03; Vol. 15 (7), pp. 1432-1455. Date of Electronic Publication: 2024 Mar 13.

Regulation of RNA degradation pathways during the lipopolysaccharide response in Macrophages.

Autor: Lai HC; Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia.; South West Sydney Clinical School, UNSW Australia, Liverpool, New South Wales, Australia., James A; Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia., Luff J; The University of Queensland Centre for Clinical Research, Herston, Queensland, Australia., De Souza P; Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia.; Medical Oncology Department, Liverpool Hospital, Liverpool, New South Wales, Australia.; School of Medicine, Western Sydney University, Macarthur, New South Wales, Australia., Quek H; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Ho U; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Lavin MF; The University of Queensland Centre for Clinical Research, Herston, Queensland, Australia., Roberts TL; Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia.; South West Sydney Clinical School, UNSW Australia, Liverpool, New South Wales, Australia.; The University of Queensland Centre for Clinical Research, Herston, Queensland, Australia.; School of Medicine, Western Sydney University, Macarthur, New South Wales, Australia.

Publikováno v: Journal of leukocyte biology [J Leukoc Biol] 2021 Mar; Vol. 109 (3), pp. 593-603. Date of Electronic Publication: 2020 Aug 23.

3D in vitro modelling of human patient microglia: A focus on clinical translation and drug development in neurodegenerative diseases.

Autor: Cuní-López C; Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane 4006, QLD, Australia; Faculty of Medicine, The University of Queensland, Brisbane 4006, QLD, Australia. Electronic address: Carla.Cuni-Lopez@qimrberghofer.edu.au., Stewart R; Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane 4006, QLD, Australia; UQ Centre for Clinical Research, The University of Queensland, Brisbane 4006, QLD, Australia. Electronic address: Romal.Stewart@qimrberghofer.edu.au., White AR; Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane 4006, QLD, Australia; School of Biomedical Science, The University of Queensland, Brisbane 4072, QLD, Australia. Electronic address: Tony.White@qimrberghofer.edu.au., Quek H; Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane 4006, QLD, Australia; School of Biomedical Science, The University of Queensland, Brisbane 4072, QLD, Australia; School of Biomedical Science, Queensland University of Technology, Brisbane 4059, QLD, Australia. Electronic address: Hazel.Quek@qimrberghofer.edu.au.

Publikováno v: Journal of neuroimmunology [J Neuroimmunol] 2023 Feb 15; Vol. 375, pp. 578017. Date of Electronic Publication: 2023 Jan 12.

An Alzheimer's Disease Patient-Derived Olfactory Stem Cell Model Identifies Gene Expression Changes Associated with Cognition.

Autor: Rantanen LM; Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.; Genomics Research Centre, Centre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, QLD 4059, Australia., Bitar M; Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia., Lampinen R; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland., Stewart R; Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia., Quek H; Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia., Oikari LE; Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia., Cunί-Lόpez C; Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia., Sutharsan R; Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia., Thillaiyampalam G; Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia., Iqbal J; Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia., Russell D; Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia., Penttilä E; Department of Otorhinolaryngology, University of Eastern Finland, Kuopio University Hospital, 70210 Kuopio, Finland., Löppönen H; Department of Otorhinolaryngology, University of Eastern Finland, Kuopio University Hospital, 70210 Kuopio, Finland., Lehtola JM; Brain Research Unit, Department of Neurology, School of Medicine, University of Eastern Finland, 70210 Kuopio, Finland.; Department of Neurology, Neuro Centre, Kuopio University Hospital, 70210 Kuopio, Finland., Saari T; Brain Research Unit, Department of Neurology, School of Medicine, University of Eastern Finland, 70210 Kuopio, Finland., Hannonen S; Brain Research Unit, Department of Neurology, School of Medicine, University of Eastern Finland, 70210 Kuopio, Finland.; Department of Neurology, Neuro Centre, Kuopio University Hospital, 70210 Kuopio, Finland., Koivisto AM; Brain Research Unit, Department of Neurology, School of Medicine, University of Eastern Finland, 70210 Kuopio, Finland.; Department of Neurology, Neuro Centre, Kuopio University Hospital, 70210 Kuopio, Finland.; Department of Neurology and Geriatrics, Helsinki University Hospital and Neurosciences, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland., Haupt LM; Genomics Research Centre, Centre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, QLD 4059, Australia., Mackay-Sim A; Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia., Cristino AS; Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia.; The University of Queensland Diamantina Institute, Brisbane, QLD 4102, Australia., Kanninen KM; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland., White AR; Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland.; Faculty of Medicine, University of Queensland, Brisbane, QLD 4072, Australia.

Publikováno v: Cells [Cells] 2022 Oct 17; Vol. 11 (20). Date of Electronic Publication: 2022 Oct 17.