Transcriptomic and proteomic profiling of NaV1.8-expressing mouse nociceptors

Autor: Manuela Schmidt, Julia Regina Sondermann, David Gomez-Varela, Cankut Çubuk, Queensta Millet, Myles J. Lewis, John N. Wood, Jing Zhao

Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2022)

Externí odkaz: https://doaj.org/article/808d70ea27fc4d60b7d71feeec7e9885

Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions [version 1; referees: 2 approved]

Autor: M.A. Bangash, Sascha R.A. Alles, Sonia Santana-Varela, Queensta Millet, Shafaq Sikandar, Larissa de Clauser, Freija ter Heegde, Abdella M. Habib, Vanessa Pereira, Jane E. Sexton, Edward C. Emery, Shengnan Li, Ana P. Luiz, Janka Erdos, Samuel J. Gossage, Jing Zhao, James J. Cox, John N. Wood

Publikováno v: Wellcome Open Research, Vol 3 (2018)

Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal root ganglia (DRG) gene expres

Externí odkaz: https://doaj.org/article/321b7fa64d604323a2606b1a61824c71

Silent cold-sensing neurons contribute to cold allodynia in neuropathic pain

Autor: Federico Iseppon, Edward C. Emery, Donald Iain MacDonald, Ana P. Luiz, Queensta Millet, John N. Wood

Publikováno v: Brain

Patients with neuropathic pain often experience innocuous cooling as excruciating pain. The cell and molecular basis of this cold allodynia is little understood. We used in vivo calcium imaging of sensory ganglia to investigate how the activity of pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf06e76762a3c06c0db0d8e1a067f8e1
https://doi.org/10.1093/brain/awab086

Sensory neuron-derived Na

Autor: Sascha R A, Alles, Filipe, Nascimento, Rafael, Luján, Ana P, Luiz, Queensta, Millet, M Ali, Bangash, Sonia, Santana-Varela, Xuelong, Zhou, James J, Cox, Andrei L, Okorokov, Marco, Beato, Jing, Zhao, John N, Wood

Publikováno v: Science Advances

An unsuspected functional role of primary afferent neuron-generated sodium channel NaV1.7 occurs in dorsal horn neurons.
Expression of the voltage-gated sodium channel NaV1.7 in sensory neurons is required for pain sensation. We examined the rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd10a7a9136dfc421938d6008fe576de
https://pubmed.ncbi.nlm.nih.gov/32128393

Inhibition of somatosensory mechanotransduction by annexin A6

Autor: Queensta Millet, Jane E. Sexton, Julie Tordo, Alice M. Fuller, Michael Linden, Stephen E. Moss, Jyoti S. Choudhary, Els Henckaerts, Stéphane Lolignier, Vanessa Pereira, Richard J. Lewis, Sonia Santana-Varela, John N. Wood, Ramin Raouf, Anna M Biller, Mark O. Collins

Publikováno v: Science Signaling
Science Signaling, American Association for the Advancement of Science, 2018, 11 (535), ⟨10.1126/scisignal.aao2060⟩
Science Signaling, American Association for the Advancement of Science (AAAS), 2018, 11 (535), ⟨10.1126/scisignal.aao2060⟩
Raouf, R, Lolignier, S, Sexton, J E, Millet, Q, Santana-Varela, S, Biller, A, Fuller, A M, Pereira, V, Choudhary, J S, Collins, M O, Moss, S E, Lewis, R, Tordo, J, Henckaerts, E, Linden, M & Wood, J N 2018, ' Inhibition of somatosensory mechanotransduction by annexin A6 ', Science Signaling, vol. 11, no. 535, eaao2060 . https://doi.org/10.1126/scisignal.aao2060

Patients with osteoarthritis experience pain when moving or, sometimes, touching the affected joints. Raouf et al. identified proteins that bound to a toxin that inhibits mechanically induced pain, including the membrane-binding protein annexin A6. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817616de32e174a126da9c7636d79807
https://hal.uca.fr/hal-03512530