Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Que N. Van"'
Autor:
Rebika Shrestha, Timothy S. Carpenter, Que N. Van, Constance Agamasu, Marco Tonelli, Fikret Aydin, De Chen, Gulcin Gulten, James N. Glosli, Cesar A. López, Tomas Oppelstrup, Chris Neale, Sandrasegaram Gnanakaran, William K. Gillette, Helgi I. Ingólfsson, Felice C. Lightstone, Andrew G. Stephen, Frederick H. Streitz, Dwight V. Nissley, Thomas J. Turbyville
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract The oncogene RAS, extensively studied for decades, presents persistent gaps in understanding, hindering the development of effective therapeutic strategies due to a lack of precise details on how RAS initiates MAPK signaling with RAF effecto
Externí odkaz:
https://doaj.org/article/c9c372b885d34294a1a4b151fe83ce95
Autor:
Rebika Shrestha, Timothy S. Carpenter, Que N. Van, Constance Agamasu, Marco Tonelli, Fikret Aydin, De Chen, Gulcin Gulten, James N. Glosli, Cesar A. López, Tomas Oppelstrup, Chris Neale, Sandrasegaram Gnanakaran, William K. Gillette, Helgi I. Ingólfsson, Felice C. Lightstone, Andrew G. Stephen, Frederick H. Streitz, Dwight V. Nissley, Thomas J. Turbyville
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/ebd31f95883b42a68c6081c546cb6fe3
Autor:
Que N. Van, Priyanka Prakash, Rebika Shrestha, Trent E. Balius, Thomas J. Turbyville, Andrew G. Stephen
Publikováno v:
Biomolecules, Vol 11, Iss 3, p 377 (2021)
RAS proteins are mutated in approximately 20% of all cancers and are generally associated with poor clinical outcomes. RAS proteins are localized to the plasma membrane and function as molecular switches, turned on by partners that receive extracellu
Externí odkaz:
https://doaj.org/article/398a71e792b1472fa938e22953542dcb
Autor:
Helgi I. Ingólfsson, Harsh Bhatia, Fikret Aydin, Tomas Oppelstrup, Cesar A. López, Liam G. Stanton, Timothy S. Carpenter, Sergio Wong, Francesco Di Natale, Xiaohua Zhang, Joseph Y. Moon, Christopher B. Stanley, Joseph R. Chavez, Kien Nguyen, Gautham Dharuman, Violetta Burns, Rebika Shrestha, Debanjan Goswami, Gulcin Gulten, Que N. Van, Arvind Ramanathan, Brian Van Essen, Nicolas W. Hengartner, Andrew G. Stephen, Thomas Turbyville, Peer-Timo Bremer, S. Gnanakaran, James N. Glosli, Felice C. Lightstone, Dwight V. Nissley, Frederick H. Streitz
Publikováno v:
Journal of Chemical Theory and Computation. 19:2658-2675
Autor:
Cesar A. López, Xiaohua Zhang, Fikret Aydin, Rebika Shrestha, Que N. Van, Christopher B. Stanley, Timothy S. Carpenter, Kien Nguyen, Lara A. Patel, De Chen, Violetta Burns, Nicolas W. Hengartner, Tyler J. E. Reddy, Harsh Bhatia, Francesco Di Natale, Timothy H. Tran, Albert H. Chan, Dhirendra K. Simanshu, Dwight V. Nissley, Frederick H. Streitz, Andrew G. Stephen, Thomas J. Turbyville, Felice C. Lightstone, Sandrasegaram Gnanakaran, Helgi I. Ingólfsson, Chris Neale
Publikováno v:
Journal of Chemical Theory and Computation. 18:5025-5045
The appeal of multiscale modeling approaches is predicated on the promise of combinatorial synergy. However, this promise can only be realized when distinct scales are combined with reciprocal consistency. Here, we consider multiscale molecular dynam
Publikováno v:
Biophys J
KRAS4B is a membrane-anchored signaling protein and a primary target in cancer research. Predictions from molecular dynamics simulations that have previously shaped our mechanistic understanding of KRAS signaling disagree with recent experimental res
Publikováno v:
The Journal of Membrane Biology
Graphic Abstract Small GTPase proteins are ubiquitous and responsible for regulating several processes related to cell growth and differentiation. Mutations that stabilize their active state can lead to uncontrolled cell proliferation and cancer. Alt
Autor:
Nicolas W. Hengartner, Timothy H. Tran, Andrew G. Stephen, Daniel Scott, Oleg Chertov, Arvind Ramanathan, William K. Gillette, Debsindhu Bhowmik, Michael L. Gross, Mathias Lösche, Xiaoying Ye, Frank Heinrich, Que N. Van, Dhirendra K. Simanshu, Simon Messing, Marco Tonelli, Troy Taylor, Sandrasegaram Gnanakaran, John L. Markley, Patrick Alexander, Dominic Esposito, Christopher B. Stanley, Matt Drew, Ben Niu, Cesar A. Lopez, Dwight V. Nissley, William M. Westler, Peter Frank, Frank McCormick
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 39
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 39
The small GTPase KRAS is localized at the plasma membrane where it functions as a molecular switch, coupling extracellular growth factor stimulation to intracellular signaling networks. In this process, KRAS recruits effectors, such as RAF kinase, to
Autor:
Kien Nguyen, Cesar A. López, Chris Neale, Que N. Van, Timothy S. Carpenter, Francesco Di Natale, Timothy Travers, Timothy H. Tran, Albert H. Chan, Harsh Bhatia, Peter H. Frank, Marco Tonelli, Xiaohua Zhang, Gulcin Gulten, Tyler Reddy, Violetta Burns, Tomas Oppelstrup, Nick Hengartner, Dhirendra K. Simanshu, Peer-Timo Bremer, De Chen, James N. Glosli, Rebika Shrestha, Thomas Turbyville, Frederick H. Streitz, Dwight V. Nissley, Helgi I. Ingólfsson, Andrew G. Stephen, Felice C. Lightstone, Sandrasegaram Gnanakaran
Publikováno v:
Biophysical journal. 121(19)
During the activation of mitogen-activated protein kinase (MAPK) signaling, the RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF bind to active RAS at the plasma membrane. The orientation of RAS at the membrane may be critical for forma
Autor:
Thomas J. Turbyville, Rebika Shrestha, Trent E. Balius, Andrew G. Stephen, Priyanka Prakash, Que N. Van
Publikováno v:
Biomolecules
Biomolecules, Vol 11, Iss 377, p 377 (2021)
Biomolecules, Vol 11, Iss 377, p 377 (2021)
RAS proteins are mutated in approximately 20% of all cancers and are generally associated with poor clinical outcomes. RAS proteins are localized to the plasma membrane and function as molecular switches, turned on by partners that receive extracellu