Výsledky vyhledávání - "Quazi Shakey"

Akademický článek

Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Urocortin 2 (UCN2) acts as a ligand for the G protein-coupled receptor corticotropin-releasing hormone receptor 2 (CRHR2). UCN2 has been reported to improve or worsen insulin sensitivity and glucose tolerance in vivo. Here we show that acute

Externí odkaz: https://doaj.org/article/c30f771320644d0bb5638ece93bbd9e2

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Integrating titania enrichment, iTRAQ labeling, and Orbitrap CID-HCD for global identification and quantitative analysis of phosphopeptides

Autor: Jiang Wu, Terence E. Ryan, Eric Sousa, Andrew A. Hill, Tao He, Peter Warren, Quazi Shakey

Publikováno v: PROTEOMICS. 10:2224-2234

Recent advances in MS instrumentation and progresses in phosphopeptide enrichment, in conjunction with more powerful data analysis tools, have facilitated unbiased characterization of thousands of site-specific phosphorylation events. Combined with s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985d3be8b6bd92233286ec5fd0887a49
https://doi.org/10.1002/pmic.200900788

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Global Profiling of Phosphopeptides by Titania Affinity Enrichment

Autor: Alwin Schuller, Wei Liu, Quazi Shakey, Maximillian T Follettie, Jiang Wu

Publikováno v: Journal of Proteome Research. 6:4684-4689

Protein phosphorylation is a ubiquitous post-translational modification critical to many cellular processes. Large-scale unbiased characterization of phosphorylation status remains a major technical challenge in proteomics. In the present work, we ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4219b0c15c0cb4744e8cdeee5015fd
https://doi.org/10.1021/pr070481m

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Preclinical Development of an anti-5T4 Antibody-Drug Conjugate: Pharmacokinetics in Mice, Rats, and NHP and Tumor/Tissue Distribution in Mice

Autor: Mauricio Leal, Nicole Duriga, Judy Lucas, Franklin Spriggs, Eugene P. Kadar, Brian Rago, Jo-Ann Wentland, Quazi Shakey, Xiaogang Han, Wei Song, Jim McNally, Leslie G. Lorello, Yanhua Zhang, Puja Sapra

Publikováno v: Bioconjugate chemistry. 26(11)

The pharmacokinetics of an antibody (huA1)-drug (auristatin microtubule disrupting MMAF) conjugate, targeting 5T4-expressing cells, were characterized during the discovery and development phases in female nu/nu mice and cynomolgus monkeys after a sin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25789a1784a3ef9e7205d6f1b0ec4a0
https://pubmed.ncbi.nlm.nih.gov/26180901

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An approach to quantifying N-linked glycoproteins by enzyme-catalyzed 18O3-labeling of solid-phase enriched glycopeptides

Autor: Quazi Shakey, Jiang Wu, Brian Bates

Publikováno v: Analytical chemistry. 82(18)

Global analysis of glycoproteins shows great promise for the discovery of therapeutic targets and clinical biomarkers. Selective capture of glycopeptides by hydrazide resin followed by mass spectrometric identification of the peptides released by PNG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897067e064bc29cc44a3dda9a15c8c9e
https://pubmed.ncbi.nlm.nih.gov/20795641

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Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells

Autor: Quazi Shakey, Celine Shi, Boris Shor, Ker Yu, Jiang Wu, Lourdes Toral-Barza, Max Follettie

Publikováno v: The Journal of biological chemistry. 285(20)

The mammalian target of rapamycin (mTOR) regulates growth via promoting translation and transcription. Here, employing an mTOR active-site inhibitor WYE-125132 (WYE-132), we have performed quantitative phospho-proteomics and identified a Ser-75-conta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb649c6836ca5e1d7fa81d82e886dbd6
https://pubmed.ncbi.nlm.nih.gov/20233713

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