Výsledky vyhledávání - "Quanxin Meng"

Plasma and cellular markers of 3′-azido-3′-dideoxythymidine (AZT) metabolism as indicators of DNA damage in cord blood mononuclear cells from infants receiving prepartum NRTIs

Autor: William L. Bigbee, Miriam C. Poirier, Nancy A. Wade, J. Patrick O'Neill, Quanxin Meng, Laurence S. Kaminsky, Elaine J. Abrams, Vernon E. Walker, Ofelia A. Olivero, Ronald Bellisario, Dale M. Walker, Carol J. Nesel, Michael J. Fasco, Roberta B. Ness, Ken A. Pass

Publikováno v: Environmental and Molecular Mutagenesis. 48:307-321

Several systemic and cellular markers of 3'-azido-3'-dideoxythymidine (AZT) metabolism and AZT incorporation into nuclear DNA were measured in cord blood from uninfected infants born to HIV-1 -infected mothers receiving prepartum therapies based on A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952ca8b81de3dc05b188a3419231e596
https://doi.org/10.1002/em.20298

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Genotoxicity assessed by the comet andGPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother–child pairs to AZT or AZT-3TC

Autor: Vernon E. Walker, Nancy A. Wade, Quanxin Meng, Miriam C. Poirier, Billy W. Day, Elaine J. Abrams, William L. Bigbee, Patricia A. Escobar, Ofelia A. Olivero, Richard D. Day, Roberta B. Ness, Carol J. Nesel, J. Patrick O'Neill, Dale M. Walker

Publikováno v: Environmental and Molecular Mutagenesis. 48:330-343

The genotoxicity of zidovudine (AZT) based treatments was investigated in human H9 lymphoblastoid cells in an in vitro study and in red blood cells (RBCs) from perinatally exposed HIV-1-infected mothers and their infants in an observational cohort st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d72b861bb209e2334946da136e2908e
https://doi.org/10.1002/em.20285

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Molecular analysis of mutations at theHPRT andTK loci of human lymphoblastoid cells after combined treatments with 3?-azido-3?-deoxythymidine and 2?,3?-dideoxyinosine

Autor: Vernon E. Walker, J. Patrick O'Neill, Ting Su, Quanxin Meng

Publikováno v: Environmental and Molecular Mutagenesis. 39:282-295

Combinations of antiretroviral drugs that include nucleoside reverse transcriptase inhibitors (NRTIs) are superior to single-agent regimens in treating or preventing HIV infection, but the potential long-term health hazards of these treatments in hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be09001c4ea32c5f0da84c42546f2dca
https://doi.org/10.1002/em.10073

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Zidovudine–didanosine coexposure potentiates DNA incorporation of zidovudine and mutagenesis in human cells

Autor: Quanxin Meng, Brendan B. Antiochos, Miriam C. Poirier, Xiaochu Shi, Dale M. Walker, Ofelia A. Olivero, Vernon E. Walker

Publikováno v: Proceedings of the National Academy of Sciences. 97:12667-12671

Drug combinations that include nucleoside reverse transcriptase inhibitors (NRTIs) are remarkably effective in preventing maternal-viral transmission of HIV during pregnancy. However, there may be potential long-term risks for children exposed in ute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0f15220d0f7da98930aa883f5aa395
https://doi.org/10.1073/pnas.220203197

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Mutagenicity and loss of heterozygosity at the APRT locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine

Autor: Xiaochu Shi, Vernon E. Walker, Quanxin Meng, Andrew J. Grosovsky

Publikováno v: Mutagenesis. 15:405-410

Previous experiments in our research group showed that 3'-azido-3'-deoxythymidine (AZT) caused increased mutant frequencies (Mfs) at the X-linked hypoxanthine-guanine phosphoribosyltransferase (HPRT) and the autosomal thymidine kinase (TK) genes in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4407128a46c62e9cd71065e291ff0328
https://doi.org/10.1093/mutage/15.5.405

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Comparison of the mutations at Hprt exon 3 of T-lymphocytes from B6C3F1 mice and F344 rats exposed by inhalation to 1,3-butadiene or the racemic mixture of 1,2:3,4-diepoxybutane

Autor: Quanxin Meng, Navjot Singh, Vernon E Walker, Michael J Bauer, Robert H. Heflich

Publikováno v: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 464:169-184

Experiments were conducted to define the spectra of mutations occurring in Hprt exon 3 of T-cells isolated from spleens of female B6C3F1 mice and F344 rats exposed by inhalation to 1,3-butadiene (BD) or its reactive metabolite, (+/-)-diepoxybutane (D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1ec3624c5860e426edc475af137837
https://doi.org/10.1016/s1383-5718(99)00157-6

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Relationships between exposure, cell loss and proliferation, and manifestation of Hprt mutant T cells following treatment of preweanling, weanling, and adult male mice with N-ethyl-N-nitrosourea

Autor: Ad D. Tates, Thomas R. Skopek, Vernon E. Walker, Michael J Bauer, Dale M. Walker, Patricia B. Upton, Andrew A. Reilly, Irene M. Jones, Quanxin Meng, Jun Nakamura, Tawni L. Crippen

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 431:371-388

Experiments were performed to characterize the age-related patterns of appearance and frequency of hypoxanthine-guanine phosphoribosyl transferase (Hprt) mutant T lymphocytes in thymus and spleen following exposure of preweanling (12-day-old), weanli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d4482b61a0560bc6d1e6a2b8f6815a1
https://doi.org/10.1016/s0027-5107(99)00180-3

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Mutagenicity of 1,3-butadiene at the Hprt locus of T-lymphocytes following inhalation exposures of female mice and rats

Autor: Vernon E Walker, Quanxin Meng, Andrew A. Reilly, Tao Chen, Dale M. Walker, Robert H. Heflich, Rogene F. Henderson, Michael J Bauer

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 429:107-125

The species specific response to 1,3-butadiene (BD), an important industrial chemical, was investigated by determining the influence of exposure duration and exposure concentration on the mutagenicity of BD in mice and rats and by defining the spectr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d095354ea128a3dd81dcf31167e9a23c
https://doi.org/10.1016/s0027-5107(99)00104-9

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Comparison of the mutagenic potency of 1,3-butadiene at the hprt locus of T-lymphocytes following inhalation exposure of female B6C3F1 mice and F344 rats

Autor: Quanxin Meng, Brian A. Wong, A. A. Reilly, M. Bauer, Vernon E. Walker, L. Recio

Publikováno v: Carcinogenesis. 19:1019-1027

1,3-Butadiene (BD) is an indirect alkylating agent that has greater cancer potency in the mouse than in the rat. The purpose of the present study was to compare the mutagenic potency of BD at the hprt locus of T-lymphocytes of exposed mice and rats a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01149ee2eae7added85020a627cbe6b0
https://doi.org/10.1093/carcin/19.6.1019

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Culture and propagation ofHprt mutant T-lymphocytes isolated from mouse spleen

Autor: Thomas R. Skopek, Shellene Hurley-Leslie, Vernon E Walker, Dale M. Walker, Tao Chen, D.M. Zimmer, Quanxin Meng

Publikováno v: Environmental and Molecular Mutagenesis. 32:236-243

The optimization of the mouse lymphocyte Hprt mutation assay has been impeded by the relatively poor growth potential of mouse T-cells in vitro, which leads to low cloning efficiencies (CEs) and limited expansion of Hprt mutant clones for molecular a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4bc87b2ce38c9701c942a5c1da83fd12
https://doi.org/10.1002/(sici)1098-2280(1998)32:3<236::aid-em6>3.0.co

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