Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Quanxin Meng"'
Autor:
William L. Bigbee, Miriam C. Poirier, Nancy A. Wade, J. Patrick O'Neill, Quanxin Meng, Laurence S. Kaminsky, Elaine J. Abrams, Vernon E. Walker, Ofelia A. Olivero, Ronald Bellisario, Dale M. Walker, Carol J. Nesel, Michael J. Fasco, Roberta B. Ness, Ken A. Pass
Publikováno v:
Environmental and Molecular Mutagenesis. 48:307-321
Several systemic and cellular markers of 3'-azido-3'-dideoxythymidine (AZT) metabolism and AZT incorporation into nuclear DNA were measured in cord blood from uninfected infants born to HIV-1 -infected mothers receiving prepartum therapies based on A
Autor:
Vernon E. Walker, Nancy A. Wade, Quanxin Meng, Miriam C. Poirier, Billy W. Day, Elaine J. Abrams, William L. Bigbee, Patricia A. Escobar, Ofelia A. Olivero, Richard D. Day, Roberta B. Ness, Carol J. Nesel, J. Patrick O'Neill, Dale M. Walker
Publikováno v:
Environmental and Molecular Mutagenesis. 48:330-343
The genotoxicity of zidovudine (AZT) based treatments was investigated in human H9 lymphoblastoid cells in an in vitro study and in red blood cells (RBCs) from perinatally exposed HIV-1-infected mothers and their infants in an observational cohort st
Publikováno v:
Environmental and Molecular Mutagenesis. 39:282-295
Combinations of antiretroviral drugs that include nucleoside reverse transcriptase inhibitors (NRTIs) are superior to single-agent regimens in treating or preventing HIV infection, but the potential long-term health hazards of these treatments in hum
Autor:
Quanxin Meng, Brendan B. Antiochos, Miriam C. Poirier, Xiaochu Shi, Dale M. Walker, Ofelia A. Olivero, Vernon E. Walker
Publikováno v:
Proceedings of the National Academy of Sciences. 97:12667-12671
Drug combinations that include nucleoside reverse transcriptase inhibitors (NRTIs) are remarkably effective in preventing maternal-viral transmission of HIV during pregnancy. However, there may be potential long-term risks for children exposed in ute
Publikováno v:
Mutagenesis. 15:405-410
Previous experiments in our research group showed that 3'-azido-3'-deoxythymidine (AZT) caused increased mutant frequencies (Mfs) at the X-linked hypoxanthine-guanine phosphoribosyltransferase (HPRT) and the autosomal thymidine kinase (TK) genes in h
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 464:169-184
Experiments were conducted to define the spectra of mutations occurring in Hprt exon 3 of T-cells isolated from spleens of female B6C3F1 mice and F344 rats exposed by inhalation to 1,3-butadiene (BD) or its reactive metabolite, (+/-)-diepoxybutane (D
Autor:
Ad D. Tates, Thomas R. Skopek, Vernon E. Walker, Michael J Bauer, Dale M. Walker, Patricia B. Upton, Andrew A. Reilly, Irene M. Jones, Quanxin Meng, Jun Nakamura, Tawni L. Crippen
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 431:371-388
Experiments were performed to characterize the age-related patterns of appearance and frequency of hypoxanthine-guanine phosphoribosyl transferase (Hprt) mutant T lymphocytes in thymus and spleen following exposure of preweanling (12-day-old), weanli
Autor:
Vernon E Walker, Quanxin Meng, Andrew A. Reilly, Tao Chen, Dale M. Walker, Robert H. Heflich, Rogene F. Henderson, Michael J Bauer
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 429:107-125
The species specific response to 1,3-butadiene (BD), an important industrial chemical, was investigated by determining the influence of exposure duration and exposure concentration on the mutagenicity of BD in mice and rats and by defining the spectr
Publikováno v:
Carcinogenesis. 19:1019-1027
1,3-Butadiene (BD) is an indirect alkylating agent that has greater cancer potency in the mouse than in the rat. The purpose of the present study was to compare the mutagenic potency of BD at the hprt locus of T-lymphocytes of exposed mice and rats a
Autor:
Thomas R. Skopek, Shellene Hurley-Leslie, Vernon E Walker, Dale M. Walker, Tao Chen, D.M. Zimmer, Quanxin Meng
Publikováno v:
Environmental and Molecular Mutagenesis. 32:236-243
The optimization of the mouse lymphocyte Hprt mutation assay has been impeded by the relatively poor growth potential of mouse T-cells in vitro, which leads to low cloning efficiencies (CEs) and limited expansion of Hprt mutant clones for molecular a