Výsledky vyhledávání - "Quanqiang, Guo"

A single‐chain variable fragment‐anticancer lytic peptide ( scFv‐ACLP ) fusion protein for targeted cancer treatment

Autor: Rui Zhang, Pengfei Pei, Yifan Wang, Quanqiang Guo, Shi‐Zhong Luo, Long Chen

Publikováno v: Chemical Biology & Drug Design. 101:1406-1415

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35e95c80878e1244a32ecf111e88af8d
https://doi.org/10.1111/cbdd.14223

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Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain

Autor: Chen, Chen, Gaohong, Fu, Quanqiang, Guo, Song, Xue, Shi-Zhong, Luo

Publikováno v: International Journal of Biological Macromolecules. 222:207-216

Liquid-liquid phase separation (LLPS) drives the formation of extensive membrane-less compartments to regulate various cellular biological activities both physiologically and pathologically. It has been widely accepted that LLPS is closely related to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9fa461bdf46bf8428bc0acde555ac0
https://doi.org/10.1016/j.ijbiomac.2022.09.087

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Computer-Aided Design of Lasso-like Self-Assembling Anticancer Peptides with Multiple Functions for Targeted Self-Delivery and Cancer Treatments

Autor: Pengfei Pei, Long Chen, Ruru Fan, Xi-Rui Zhou, Shan Feng, Hangrui Liu, Quanqiang Guo, Huiwei Yin, Qiang Zhang, Fude Sun, Liang Peng, Peng Wei, Chengzhi He, Renzhong Qiao, Zai Wang, Shi-Zhong Luo

Publikováno v: ACS Nano. 16:13783-13799

Anticancer peptides are promising drug candidates for cancer treatment, but the short circulation time and low delivery efficiency limit their clinical applications. Herein, we designed several lasso-like self-assembling anticancer peptides (LASAPs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de64782511475f6851cf0e05449db92
https://doi.org/10.1021/acsnano.2c01014

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The SGYS motif of TAF15 prion-like domain is critical to amyloid fibril formation

Autor: Jialin Chen, Xiushuang Yuan, Peng Wei, Daoping Wang, Chen Chen, Quanqiang Guo, Shi-Zhong Luo, Long Chen

Publikováno v: Biophys J

Misfolding of TATA-box binding protein-associated factor 15 (TAF15) may cause neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). Some mutations of prion-like domain (PrLD) have been detected in patients with sporadic ALS, sugges

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a89ca1f6c0b903dfd4664986977356ee
https://doi.org/10.1016/j.bpj.2022.05.038

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