Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Quanlai Song"'
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. May2005, Vol. 24 Issue 5-7, p815-818. 4p. 1 Diagram.
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 24:815-818
We describe an improved process to produce 2'-O-(2-methoxyethyl)-pyrimidines. Starting with commercially available O-2,2'-anhydro-5-methyluridine and tris-(2-methoxyethyl)borate, we modified the ring-opening reaction conditions and changed to a conti
Autor:
Michele Bosserman, Neelima Bhat, Joanne E Tomassini, Sanjib Bera, Marija Prhavc, Christine Burlein, Malcolm MacCoss, Charles R. Allerson, Jennifer L. Brooks, David B. Olsen, Jie Xia, Balkrishen Bhat, C. Frank Bennett, Steven S. Carroll, P. Dan Cook, Quanlai Song, Krista Getty, Anne B. Eldrup, Daniel R. McMasters, Thazha P. Prakash
Publikováno v:
Journal of Medicinal Chemistry. 47:2283-2295
As part of a continued effort to identify inhibitors of hepatitis C viral (HCV) replication, we report here the synthesis and evaluation of a series of nucleoside analogues and their corresponding triphosphates. Nucleosides were evaluated for their a
Autor:
Yogesh S. Sanghvi, Quanlai Song
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 20:1267-1270
An improved and scalable protocol for the synthesis of 3'-O-succinates of nucleosides has been developed using succinic anhydride. As a result, formation of unwanted dimer has been completely eliminated and use of toxic and smelly reagents have been
Autor:
Quanlai Song, Wayne Lloyd, Colin B. Reese, Cristina Visintin, Anthony M. Vandersteen, P.‐Z. Zhang
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :165-176
The comparative rates of acid-catalysed removal of ten 1-aryl-4-methoxypiperidin-4-yl 8 (R = Me) [including the previously reported Ctmp 5 and Fpmp 6] protecting groups for the 2′-hydroxy functions in oligoribonucleotide synthesis are discussed. Th
Publikováno v:
Tetrahedron Letters. 40:8971-8974
Nucleoside phosphoramidites and H-phosphonate diesters can be converted to nucleosides under mild conditions and in high yields by reaction with polyhydroxy alcohols.
Autor:
Quanlai Song, Colin B. Reese
Publikováno v:
Nucleic Acids Research. 27:2672-2681
The six-step synthesis of the di-triethylammonium salt of 5[prime]-O -trityl-6-N-pivaloyladenosine-2[prime]-(H -phosphonate)-3'-[(2-chlorophenyl) phosphate]9 from 3', 5'- O -(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)-6-N-pivaloyla denosine1in 68% ove
Autor:
Colin B. Reese, Quanlai Song
Publikováno v:
Nucleosides and Nucleotides. 18:1175-1180
The tetraribonucleoside triphosphate 15 and the cyclic tetraribonucleotide 16 have been prepared by a recently reported triester approach in solution, involving H-phosphonate coupling.
Publikováno v:
Tetrahedron. 55:5635-5640
Reaction between aluminium 2-methoxyethoxide and 2,2′-anhydro-1-β- d -arabinofuranosyluracil 6 gives 2′-O-(2-methoxyethyl)uridine 9 in high yield. Compound 9 is converted into 2′-O-(2-methoxyethyl)cytidine 11 in good yield.
Publikováno v:
Tetrahedron. 55:5239-5252
Guanine 11 was converted, in a one pot reaction, into 2-amino-6-[(4-chlorophenyl)sulfanyl]purine 9a in 88% isolated yield. 4-Acetoxy-3-(acetoxymethyl)butanol 23 was prepared from 2-chloroethanol in five steps and in 46% overall yield. The mesylate es