Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Quanjiang Ji"'
Autor:
Tengfei Ma, Ning Xie, Yuan Gao, Jiani Fu, Chun E. Tan, Qiu E. Yang, Shaolin Wang, Zhangqi Shen, Quanjiang Ji, Julian Parkhill, Congming Wu, Yang Wang, Timothy R. Walsh, Jianzhong Shen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract IncX3 plasmids carrying the New Delhi metallo-β-lactamase-encoding gene, bla NDM-5, are rapidly spreading globally in both humans and animals. Given that carbapenems are listed on the WHO AWaRe watch group and are prohibited for use in anim
Externí odkaz:
https://doaj.org/article/0c8fbbf9704240e494654433d6bec2e6
Autor:
Hongyuan Zhang, Jiacheng Ma, Zhaowei Wu, Xiaoyang Chen, Yangyang Qian, Weizhong Chen, Zhipeng Wang, Ya Zhang, Huanhu Zhu, Xingxu Huang, Quanjiang Ji
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Prime editing allows precise installation of any single base substitution and small insertions and deletions without requiring homologous recombination or double-strand DNA breaks in eukaryotic cells. However, the applications in bacteria ar
Externí odkaz:
https://doaj.org/article/e15a79ab62b849aa88bd001bbfc6ecf4
Autor:
Xiangyang Li, Guiquan Zhang, Shisheng Huang, Yao Liu, Jin Tang, Mingtian Zhong, Xin Wang, Wenjun Sun, Yuan Yao, Quanjiang Ji, Xiaolong Wang, Jianghuai Liu, Shiqiang Zhu, Xingxu Huang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Strategies to improve the specificity of nuclease-based prime editor (PEn) are needed. Here the authors report a 53BP1-inhibitory ubiquitin variant-assisted PEn platform (uPEn) to inhibit NHEJ and enable precise prime editing for generation of insert
Externí odkaz:
https://doaj.org/article/8fd853d8eeec49ba93a2f10e2893f7db
Autor:
Bingyan Wei, Tao Zhang, Pengyu Wang, Yihui Pan, Jiahui Li, Weizhong Chen, Min Zhang, Quanjiang Ji, Wenjuan Wu, Lefu Lan, Jianhua Gan, Cai-Guang Yang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The development of selective ClpP activators targeting only the MRSA isolates without interfering with the human variant is currently challenging. Here, the authors report on the structure-based design of enantiomers of ZG197 and identify the discrim
Externí odkaz:
https://doaj.org/article/3ad823d96ae14bc0b6151b4bf9628fa0
Autor:
Hongyuan Zhang, Yifei Zhang, Wei-Xiao Wang, Weizhong Chen, Xia Zhang, Xingxu Huang, Wei Chen, Quanjiang Ji
Publikováno v:
Engineering, Vol 15, Iss , Pp 67-77 (2022)
New therapeutic strategies for the rapid and effective treatment of drug-resistant tuberculosis are highly desirable, and their development can be drastically accelerated by facile genetic manipulation methods in Mycobacterium tuberculosis (M. tuberc
Externí odkaz:
https://doaj.org/article/f27a6c8cff7b4c488e2086640e0092c1
Autor:
Guiquan Zhang, Yao Liu, Shisheng Huang, Shiyuan Qu, Daolin Cheng, Yuan Yao, Quanjiang Ji, Xiaolong Wang, Xingxu Huang, Jianghuai Liu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The prime editors (PEs) have shown great promise for precise genome modification. Here the authors place a stabilizing viral xrRNA motif to the 3′ of pegRNAs to enhance editing efficiencies.
Externí odkaz:
https://doaj.org/article/1cf8f98c022e4d528ea7403e45e88118
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6259-6270 (2022)
Transcription factors (TFs) play important roles in regulating multiple biological processes by binding to promoter regions and regulating the global gene transcription levels. Pseudomonas syringae is a Gram-negative phytopathogenic bacterium harbour
Externí odkaz:
https://doaj.org/article/2157dff1b8144d5dabaed3f73fb3fcff
Autor:
Yin Liu, Yanling Chen, Lu Dang, Yixin Liu, Shisheng Huang, Sanyun Wu, Peixiang Ma, Hongqiang Jiang, Yi Li, Yunbao Pan, Yongchang Wei, Xiaodong Ma, Ming Liu, Quanjiang Ji, Tian Chi, Xingxu Huang, Xinjie Wang, Fuling Zhou
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-7 (2021)
Externí odkaz:
https://doaj.org/article/80caa59c250d4ef08d0989f9f5f011a1
Autor:
Xueting Huang, Xiuyuan Li, Haoran An, Juanjuan Wang, Ming Ding, Lijun Wang, Lulu Li, Quanjiang Ji, Fen Qu, Hui Wang, Yingchun Xu, Xinxin Lu, Yuan He, Jing-Ren Zhang
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010693 (2022)
Polysaccharide capsule is the main virulence factor of K. pneumoniae, a major pathogen of bloodstream infections in humans. While more than 80 capsular serotypes have been identified in K. pneumoniae, only several serotypes are frequently identified
Externí odkaz:
https://doaj.org/article/3388a9b4cf764140937c46468b3b3bb9
Publikováno v:
mSystems, Vol 5, Iss 5 (2020)
ABSTRACT Base editing is a promising technique, allowing precise single-base mutagenesis in genomes without double-strand DNA breaks or donor templates. Cytosine base editors (CBEs) convert cytosine to thymidine. In particular, CBEs can transform fou
Externí odkaz:
https://doaj.org/article/5ca65d01d88c431994308779e20aff34