Distinct Protein Kinase C isoforms drive the cell cycle re-entry of two separate populations of neonatal rat ventricular cardiomyocytes

Autor: Mariana Kebbe, Patrice Naud, Ines Assous, Emmanuelle Gagnon, Anthony McCall, Louis Villeneuve, Charles Alexandre LeBlanc, Quang Trinh Nguyen, Angelino Calderone

Publikováno v: American Journal of Physiology-Cell Physiology.

The present study tested the hypothesis that PKC-α recruitment in the presence of the p38α/β MAPK inhibitor SB203580 facilitated the appearance and cell cycle re-entry of nestin(+)-neonatal rat ventricular cardiomyocytes (NNVMs) and induced a tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c68007296c3cb84f1d77df14a282b67f
https://doi.org/10.1152/ajpcell.00506.2022

Benefits of PBI-4425 on Acute Respiratory Failure in Oleic Acid-Induced Lung Injury

Autor: Brigitte Grouix, Jocelyn Dupuis, Lyne Gagnon, Mohamed J Nsaibia, Martin G. Sirois, Quang Trinh Nguyen

Publikováno v: D108. WHAT IS HOT, WHAT IS NEW? EMERGING MOLECULAR TARGETS IN PULMONARY HYPERTENSION AND ACUTE LUNG INJURY.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::311597df90c989bfe88a7963058e80d0
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7855

PulmoBind Imaging Measures Reduction of Vascular Adrenomedullin Receptor Activity with Lack of effect of Sildenafil in Pulmonary Hypertension

Autor: Nassiba Merabet, François Harel, Alain Fournier, Yan Fen Shi, Quang Trinh Nguyen, Jocelyn Dupuis, Mohamed J Nsaibia, Myriam Létourneau, Jean-Claude Tardif

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.6609. ⟨10.1038/s41598-019-43225-3⟩

Endothelial dysfunction is a core pathophysiologic process in pulmonary arterial hypertension (PAH). We developed PulmoBind (PB), a novel imaging biomarker of the pulmonary vascular endothelium. 99mTechnetium (99mTc)-labelled PB binds to adrenomedull

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196f58ba9daf491f7c8937e8b7b3456e
https://pubmed.ncbi.nlm.nih.gov/31036871

PulmoBind, an Adrenomedullin-Based Molecular Lung Imaging Tool

Autor: François Harel, Jocelyn Dupuis, Alain Fournier, Myriam Létourneau, Quang Trinh Nguyen

Publikováno v: Journal of Nuclear Medicine
Journal of Nuclear Medicine, Society of Nuclear Medicine, 2013, 54 (10), pp.1789-96. ⟨10.2967/jnumed.112.118984⟩

Previous studies showed that adrenomedullin (AM) could be a promising agent for molecular imaging of the pulmonary circulation, with abundant specific binding sites at the pulmonary vascular endothelium. The purpose of this work was to design an AM-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ba9d9072e6425215a66fe72bef3cc4
https://doi.org/10.2967/jnumed.112.118984

Urocontrin, a novel UT receptor ligand with a unique pharmacological profile

Autor: Jocelyn Dupuis, David Chatenet, Alain Fournier, Myriam Létourneau, Quang-Trinh Nguyen

Publikováno v: Advances in Experimental Medicine and Biology
Advances in Experimental Medicine and Biology, Kluwer, 2012, 83 (5), pp.608-15. ⟨10.1016/j.bcp.2011.12.009⟩

International audience; In recent years, several studies have demonstrated that urotensin II (UII) and urotensin II-related peptide (URP) can exhibit differential biological activity. So far, known antagonists of the urotensin II receptor (UT) are of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11df0712fb7c221548187c82ebab41c9
https://doi.org/10.1016/j.bcp.2011.12.009