Zobrazeno 1 - 10
of 47
pro vyhledávání: '"QuanXiao Li"'
Autor:
Huiyu Cai, Zuobai Zhang, Mingkai Wang, Bozitao Zhong, Quanxiao Li, Yuxuan Zhong, Yanling Wu, Tianlei Ying, Jian Tang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Increasing the binding affinity of an antibody to its target antigen is a crucial task in antibody therapeutics development. This paper presents a pretrainable geometric graph neural network, GearBind, and explores its potential in in silico
Externí odkaz:
https://doaj.org/article/326a856cdb144984ae87d5a5ddcdd218
Publikováno v:
Biomolecules, Vol 14, Iss 11, p 1399 (2024)
Monoclonal antibodies (mAbs) are widely used in cancer therapy but often show limited efficacy for solid tumors. Enhancing anti-tumor activity by fusing cytokines to tumor-targeting mAbs, which specifically activate immune cells within the tumor micr
Externí odkaz:
https://doaj.org/article/4b8c2679e6ee4da29119a3015d185635
Publikováno v:
MedComm, Vol 5, Iss 5, Pp n/a-n/a (2024)
Abstract Single‐domain antibody–drug conjugates (sdADCs) have been proven to have deeper solid tumor penetration and intratumor accumulation capabilities due to their smaller size compared with traditional IgG format ADCs. However, one of the key
Externí odkaz:
https://doaj.org/article/a82ab916581c41bf94b1b718a6ead906
Autor:
Huiyu Cai, Zuobai Zhang, Mingkai Wang, Bozitao Zhong, Quanxiao Li, Yuxuan Zhong, Yanling Wu, Tianlei Ying, Jian Tang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/98460e236461463ea1eeee6f57b32f88
Autor:
Huifang Wu, Dan Hu, Quanxiao Li, Chunyu Wang, Xiaoyi Zhu, Wei Li, Binfan Chen, Ping Ji, Keke Huang, Ailing Huang, Jinghe Huang, Dimiter S. Dimitrov, Yanling Wu, Tianlei Ying
Publikováno v:
Engineering, Vol 21, Iss , Pp 203-213 (2023)
Prolonged half-life of protein-based therapeutics can improve drug efficacy. However, the impact of drug half-life on gene therapy, which inherently provides long-lasting production of the desired therapeutic protein, remains unclear. In this study,
Externí odkaz:
https://doaj.org/article/bbef79bc33864029a955978d092f89a0
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Regulatory T cells (Tregs) are among the most abundant suppressive cells, which infiltrate and accumulate in the tumor microenvironment, leading to tumor escape by inducing anergy and immunosuppression. Their presence has been correlated with tumor p
Externí odkaz:
https://doaj.org/article/198c17560d874f2aaa58c5e03b194130
Publikováno v:
Materials & Design, Vol 227, Iss , Pp 111777- (2023)
Although radiotherapy has become indispensable for tumor treatment in recent years, the inevitable side effects of high-dose radiation on the normal tissue and deficiency of appropriate radiosensitizers without long-term body retention that do not ca
Externí odkaz:
https://doaj.org/article/c52bb75f9c884d9f9329f84263e63e07
Publikováno v:
Food and Agricultural Immunology, Vol 32, Iss 1, Pp 557-575 (2021)
Artemisia rupestris L. polysaccharides have immune enhancement effects with low toxicity in the previous studies. The effect of crude polysaccharides from cultivated Artemisia rupestris L. (CPCAR) on immunity has not been explored. Here, the adjuvant
Externí odkaz:
https://doaj.org/article/24e87446a8c54908bf447e66619da4bc
Publikováno v:
Journal of Functional Foods, Vol 87, Iss , Pp 104800- (2021)
Cistanche deserticola Y. C. Ma (CD) are ideal herbal remedies for health problems. In this study, modulator activities of CPCD on activating dendritic cells (DCs) and the adjuvant potential for foot-and-mouth disease vaccine (FMDV) was evaluated. CPC
Externí odkaz:
https://doaj.org/article/c63d67dfeab040269591a4b8548f3768
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Hepatocellular carcinoma (HCC) is the most common form of liver cancer with limited therapeutic options and low survival rate. The hypoxic microenvironment plays a vital role in progression, metabolism, and prognosis of malignancies. Therefore, this
Externí odkaz:
https://doaj.org/article/215382bd745a47ad848678e1401c7ba9