Výsledky vyhledávání - "Quan Karen, Zhu"

Akademický článek

Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses

Autor: Wayne D. Harshbarger, Derrick Deming, Gordon J. Lockbaum, Nattapol Attatippaholkun, Maliwan Kamkaew, Shurong Hou, Mohan Somasundaran, Jennifer P. Wang, Robert W. Finberg, Quan Karen Zhu, Celia A. Schiffer, Wayne A. Marasco

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Previously, a broadly neutralizing antibody, 3I14, active against groups 1 and 2 influenza A viruses was isolated from human memory B cells and showed protection in mice from lethal viral challenge. Here, Harshbarger and Deming et al. provide the cry

Externí odkaz: https://doaj.org/article/246479680d0d43448f6a2d4b305f320c

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Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses

Autor: Jennifer P. Wang, Robert W. Finberg, Wayne A. Marasco, Gordon J. Lockbaum, Mohan Somasundaran, Wayne D Harshbarger, Derrick Deming, Quan Karen Zhu, Nattapol Attatippaholkun, Celia A. Schiffer, Shurong Hou, Maliwan Kamkaew

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Broadly neutralizing antibodies (bnAbs) targeting conserved influenza A virus (IAV) hemagglutinin (HA) epitopes can provide valuable information for accelerating universal vaccine designs. Here, we report structural details for heterosubtypic recogni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb5870d6b18ca88328d76443f6014d5
https://doaj.org/article/246479680d0d43448f6a2d4b305f320c

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Unique structural solution from a V

Autor: Wayne D, Harshbarger, Derrick, Deming, Gordon J, Lockbaum, Nattapol, Attatippaholkun, Maliwan, Kamkaew, Shurong, Hou, Mohan, Somasundaran, Jennifer P, Wang, Robert W, Finberg, Quan Karen, Zhu, Celia A, Schiffer, Wayne A, Marasco

Publikováno v: Nature Communications

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15b9c16e91926b1dd7f0959ccce24514
https://pubmed.ncbi.nlm.nih.gov/33495478

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Alcohol consumption increases susceptibility to pneumococcal pneumonia in a humanized murine HIV model mediated by intestinal dysbiosis

Autor: Meng Luo, Derrick R. Samuelson, Wayne A. Marasco, Sanbao Ruan, David A. Welsh, Angela M. Amedee, Robert W. Siggins, Christopher M. Taylor, Judd E. Shellito, Jiusong Sun, Quan Karen Zhu

Publikováno v: Alcohol

Alcohol use in persons living with HIV (PLWH) worsens the severity of bacterial pneumonia. However, the exact mechanism(s) by which this occurs remain ill-defined. We hypothesized that alcohol in the setting of HIV infection decreases Streptococcus p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b993569ee8a803fce17e16d23cb37fd1
https://pubmed.ncbi.nlm.nih.gov/30213614

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Human B-cell ontogeny in humanized NOD/SCID γcnull mice generates a diverse yet auto/poly- and HIV-1-reactive antibody repertoire

Autor: Madhura M. Panditrao, Wayne A. Marasco, Subhabrata Biswas, Phuong Thi Nguyen Sarkis, Shusheng Geng, Quan Karen Zhu, Hong Chang, Aimee St. Clair Tallarico

Publikováno v: Genes and immunity

Characterization of the human antibody (Ab) repertoire in mouse models of the human immune system is essential to establish their relevance in translational studies. Single human B cells were sorted from bone marrow and periphery of humanized NOD/SCI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8463b056d66e005d23e722ee8577c61d
https://doi.org/10.1038/gene.2012.16

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Human anti-CCR4 minibody gene transfer for the treatment of cutaneous T-cell lymphoma

Autor: Wayne A. Marasco, Thomas Han, James Campbell, Jianhua Sui, De-Kuan Chang, Quan Karen Zhu, Asli Muvaffak, Thomas S. Kupper, Ussama M. Abdel-Motal

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 9, p e44455 (2012)

Background: Although several therapeutic options have become available for patients with Cutaneous T-cell Lymphoma (CTCL), no therapy has been curative. Recent studies have demonstrated that CTCL cells overexpress the CC chemokine receptor 4 (CCR4).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5466f9c197abbd3fd41198b30d85e7f9
https://pubmed.ncbi.nlm.nih.gov/22973452

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Unique biological properties of catalytic domain directed human anti-CAIX antibodies discovered through phage-display technology

Autor: Kristen W. Brady, Wayne A. Marasco, Anuradha Yammanuru, Agnes Lo, Aimee St. Clair Tallarico, Chen Xu, Quan Karen Zhu, Akikazu Murakami, Natasha S. Barteneva

Publikováno v: PLoS ONE, Vol 5, Iss 3, p e9625 (2010)
PLoS ONE

Carbonic anhydrase IX (CAIX, gene G250/MN-encoded transmembrane protein) is highly expressed in various human epithelial tumors such as renal clear cell carcinoma (RCC), but absent from the corresponding normal tissues. Besides the CA signal transduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69179238fdd5bdc89972351cf1cc19be
http://europepmc.org/articles/PMC2835754?pdf=render

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Lentivirus display: stable expression of human antibodies on the surface of human cells and virus particles

Autor: Daniel Aird, Quan Karen Zhu, Wayne A. Marasco, Erick Kamau, Ran Taube, Jianhua Sui, Markryan Dwyer, Chen Xu, Felipe Diaz-Griffero

Publikováno v: PLoS ONE
PLoS ONE, Vol 3, Iss 9, p e3181 (2008)

Background Isolation of human antibodies using current display technologies can be limited by constraints on protein expression, folding and post-translational modifications. Here we describe a discovery platform that utilizes self-inactivating (SIN)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4888f1c6d58e1c0ecdaa2d7bee287ce0
https://pubmed.ncbi.nlm.nih.gov/18784843

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