Glucocorticoid-loaded core-crosslinked polymeric micelles with tailorable release kinetics for targeted rheumatoid arthritis therapy**

Autor: Crielaard, Bart J., Rijcken, Cristianne J.F., Quan, Lingdong, van der Wal, Steffen, Altintas, Isil, van der Pot, Martin, Kruijtzer, John A.W., Liskamp, Rob M.J., Schiffelers, Raymond M., van Nostrum, Cornelus F., Hennink, Wim E., Wang, Dong, Lammers, Twan, Storm, Gert

To achieve highly effective glucocorticoid targeting for rheumatoid arthritis therapy, novel, polymerizable and hydrolytically cleavable dexamethasone (DEX) derivatives were covalently entrapped in core-crosslinked polymeric micelles. By varying the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::76205a7ab62b3a0cc50631c349ee651f
https://europepmc.org/articles/PMC3499037/

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Nanomedicines for inflammatory arthritis: head-to-head comparison of glucocorticoid-containing polymers, micelles, and liposomes.

Autor: Quan L; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, (USA)., Zhang Y; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, (USA)., Crielaard BJ; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, (The Netherlands)., Dusad A; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, (USA)., Lele SM; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, (USA)., Rijcken CJF; Cristal Delivery B.V. Oxfordlaan 55, 6229 EV Maastricht, (The Netherlands)., Metselaar JM; Department of Targeted Therapeutics, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500 AE, Enschede (The Netherlands)., Kostková H; Institute of Macromolecular Chemistry AS CR, v.v.i., Heyrovského nám. 2, 162 06 Prague 6, (Czech Republic)., Etrych T; Institute of Macromolecular Chemistry AS CR, v.v.i., Heyrovského nám. 2, 162 06 Prague 6, (Czech Republic)., Ulbrich K; Institute of Macromolecular Chemistry AS CR, v.v.i., Heyrovského nám. 2, 162 06 Prague 6, (Czech Republic)., Kiessling F; Department of Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, RWTH - Aachen University, Pauwelsstrasse 30, 52074 Aachen (Germany)., Mikuls TR; Omaha VA Medical Center, 4101 Woolworth Avenue, Omaha, (USA).; Department Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE 68198, (USA)., Hennink WE; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, (The Netherlands)., Storm G; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, (The Netherlands).; Department of Targeted Therapeutics, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500 AE, Enschede (The Netherlands)., Lammers T; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, (The Netherlands).; Department of Targeted Therapeutics, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500 AE, Enschede (The Netherlands).; Department of Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, RWTH - Aachen University, Pauwelsstrasse 30, 52074 Aachen (Germany)., Wang D; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, (USA).

Publikováno v: ACS nano [ACS Nano] 2014 Jan 28; Vol. 8 (1), pp. 458-466. Date of Electronic Publication: 2013 Dec 27.