Immune landscape of oncohistone-mutant gliomas reveals diverse myeloid populations and tumor-promoting function.

Autor: Andrade AF; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada.; The Research Institute of the McGill University Health Centre, Montreal, QC, H4A 3J1, Canada., Annett A; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada., Karimi E; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada., Topouza DG; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada., Rezanejad M; Departments of Psychology and Computer Science, University of Toronto, Toronto, ON, M5S 3G3, M5S 2E4, Canada., Liu Y; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada., McNicholas M; Department of Oncology and The Milner Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK.; CRUK Children's Brain Tumour Centre of Excellence, University of Cambridge, Cambridge, E20 1JQ, UK., Gonzalez Santiago EG; Department of Pediatrics, Yale School of Medicine, New Haven, CT, 06510, USA., Llivichuzhca-Loja D; Department of Pediatrics, Yale School of Medicine, New Haven, CT, 06510, USA., Gehlhaar A; Life and Medical Sciences Institute, University of Bonn, Bonn, 53115, Germany., Jessa S; Quantitative Life Sciences, McGill University, Montreal, QC, Canada.; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC, H3T 1E2, Canada., De Cola A; Department of Oncology and The Milner Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK.; CRUK Children's Brain Tumour Centre of Excellence, University of Cambridge, Cambridge, E20 1JQ, UK., Chandarana B; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada., Russo C; The Research Institute of the McGill University Health Centre, Montreal, QC, H4A 3J1, Canada.; Department of Pediatrics, McGill University, Montreal, QC, H4A 3J1, Canada., Faury D; The Research Institute of the McGill University Health Centre, Montreal, QC, H4A 3J1, Canada.; Department of Pediatrics, McGill University, Montreal, QC, H4A 3J1, Canada., Danieau G; Cancer Research Program, The Research Institute of the McGill University Health Centre, Montreal, QC, H4A 3J1, Canada.; Division of Orthopedic Surgery, McGill University Health Centre, Montreal, QC, H4A 3J1, Canada., Puligandla E; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada., Wei Y; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada., Zeinieh M; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada., Wu Q; The Research Institute of the McGill University Health Centre, Montreal, QC, H4A 3J1, Canada.; Department of Pediatrics, McGill University, Montreal, QC, H4A 3J1, Canada., Hebert S; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada.; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC, H3T 1E2, Canada., Juretic N; The Research Institute of the McGill University Health Centre, Montreal, QC, H4A 3J1, Canada.; Department of Pediatrics, McGill University, Montreal, QC, H4A 3J1, Canada., Nakada EM; The Research Institute of the McGill University Health Centre, Montreal, QC, H4A 3J1, Canada.; Department of Pediatrics, McGill University, Montreal, QC, H4A 3J1, Canada., Krug B; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada., Larouche V; Department of Pediatrics, Centre mère-enfant Soleil du CHU de Québec-Université Laval, Quebec City, QC, G1V 4G2, Canada., Weil AG; Brain and Development Research Axis, Sainte-Justine Research Centre, Montreal, QC, H3T 1C5, Canada.; Division of Neurosurgery, Department of Surgery, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montreal, QC, H3T 1C5, Canada.; Department of Neuroscience, University of Montreal, Montreal, QC, H2X 0A9, Canada., Dudley RWR; Department of Pediatric Surgery, Division of Neurosurgery, Montreal Children's Hospital, McGill University, Montreal, QC, H4A 3J1, Canada., Karamchandani J; Department of Pathology, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada., Agnihotri S; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA., Quail DF; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada.; Department of Physiology, Faculty of Medicine, McGill University, Montreal, QC, H3G 1Y6, Canada.; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC, H4A 3J1, Canada., Ellezam B; Division of Pathology, Department of Pathology and Cell Biology, CHU Sainte-Justine, Université de Montréal, Montreal, QC, H3T 1C5, Canada., Konnikova L; Department of Pediatrics, Yale School of Medicine, New Haven, CT, 06510, USA. liza.konnikova@yale.edu.; Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, 06510, USA. liza.konnikova@yale.edu.; Human and Translational Immunology Program, Yale School of Medicine, New Haven, CT, 06510, USA. liza.konnikova@yale.edu., Walsh LA; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada.; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada., Pathania M; Department of Oncology and The Milner Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK. mp915@cam.ac.uk.; CRUK Children's Brain Tumour Centre of Excellence, University of Cambridge, Cambridge, E20 1JQ, UK. mp915@cam.ac.uk., Kleinman CL; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada. claudia.kleinman@mcgill.ca.; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC, H3T 1E2, Canada. claudia.kleinman@mcgill.ca., Jabado N; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada. nada.jabado@mcgill.ca.; The Research Institute of the McGill University Health Centre, Montreal, QC, H4A 3J1, Canada. nada.jabado@mcgill.ca.; Department of Pediatrics, McGill University, Montreal, QC, H4A 3J1, Canada. nada.jabado@mcgill.ca.; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC, H4A 3J1, Canada. nada.jabado@mcgill.ca.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 05; Vol. 15 (1), pp. 7769. Date of Electronic Publication: 2024 Sep 05.

Exploring the prognostic significance of arm-level copy number alterations in triple-negative breast cancer.

Autor: Doré S; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada., Ali M; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada., Sorin M; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada., McDowell SAC; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, Canada.; Department of Physiology, Faculty of Medicine, McGill University, Montreal, QC, Canada., Desharnais L; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada., Breton V; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada., Yu MW; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, Canada.; Department of Physiology, Faculty of Medicine, McGill University, Montreal, QC, Canada., Arabzadeh A; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, Canada., Ryan MI; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, Canada.; Department of Surgery, McGill University Health Center, Montreal, QC, Canada., Milette S; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, Canada.; Department of Experimental Medicine, McGill University, Montreal, QC, Canada., Quail DF; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, Canada.; Department of Physiology, Faculty of Medicine, McGill University, Montreal, QC, Canada.; Department of Experimental Medicine, McGill University, Montreal, QC, Canada., Walsh LA; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, Canada. logan.walsh@mcgill.ca.; Department of Human Genetics, McGill University, Montreal, QC, Canada. logan.walsh@mcgill.ca.

Publikováno v: Oncogene [Oncogene] 2024 Jun; Vol. 43 (26), pp. 2015-2024. Date of Electronic Publication: 2024 May 14.

Cancer Hallmarks: Piecing the Puzzle Together.

Autor: Alcolea MP, Alonso-Curbelo D, Ambrogio C, Bullman S, Correia AL, Ernst A, Halbrook CJ, Kelly GL, Lund AW, Quail DF, Ruscetti M, Shema E, Stromnes IM, Tam WL

Publikováno v: Cancer discovery [Cancer Discov] 2024 Apr 04; Vol. 14 (4), pp. 674-682.

Lifestyle and host determinants of antitumor immunity and cancer health disparities.

Autor: Swaby A; Goodman Cancer Research Institute, Montreal, QC, Canada; Department of Experimental Medicine, McGill University, Montreal, QC, Canada., Atallah A; Goodman Cancer Research Institute, Montreal, QC, Canada; Department of Experimental Medicine, McGill University, Montreal, QC, Canada., Varol O; Goodman Cancer Research Institute, Montreal, QC, Canada; Department of Experimental Medicine, McGill University, Montreal, QC, Canada., Cristea A; Goodman Cancer Research Institute, Montreal, QC, Canada; Department of Experimental Medicine, McGill University, Montreal, QC, Canada., Quail DF; Goodman Cancer Research Institute, Montreal, QC, Canada; Department of Experimental Medicine, McGill University, Montreal, QC, Canada; Department of Physiology, McGill University, Montreal, QC, Canada. Electronic address: daniela.quail@mcgill.ca.

Publikováno v: Trends in cancer [Trends Cancer] 2023 Dec; Vol. 9 (12), pp. 1019-1040. Date of Electronic Publication: 2023 Sep 16.

Agent-Based Modelling Reveals the Role of the Tumor Microenvironment on the Short-Term Success of Combination Temozolomide/Immune Checkpoint Blockade to Treat Glioblastoma.

Autor: Surendran A; Department of Mathematics and Statistics, Université de Montréal, Montréal, Canada (A.S., M.C.); Centre de recherches mathématiques, Montréal, Canada (A.S.); School of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia (A.L.J.); Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Canada (E.K., B.F., D.F.Q., L.A.W.); Department of Physiology, Faculty of Medicine, McGill University, Montréal, Canada (D.F.Q.); Department of Medicine, Division of Experimental Medicine, McGill University, Montréal, Canada (D.F.Q.); Department of Human Genetics, McGill University, Montréal, Canada (L.A.W.); and Sainte-Justine University Hospital Research Centre, Montréal, Canada (M.C.)., Jenner AL; Department of Mathematics and Statistics, Université de Montréal, Montréal, Canada (A.S., M.C.); Centre de recherches mathématiques, Montréal, Canada (A.S.); School of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia (A.L.J.); Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Canada (E.K., B.F., D.F.Q., L.A.W.); Department of Physiology, Faculty of Medicine, McGill University, Montréal, Canada (D.F.Q.); Department of Medicine, Division of Experimental Medicine, McGill University, Montréal, Canada (D.F.Q.); Department of Human Genetics, McGill University, Montréal, Canada (L.A.W.); and Sainte-Justine University Hospital Research Centre, Montréal, Canada (M.C.)., Karimi E; Department of Mathematics and Statistics, Université de Montréal, Montréal, Canada (A.S., M.C.); Centre de recherches mathématiques, Montréal, Canada (A.S.); School of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia (A.L.J.); Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Canada (E.K., B.F., D.F.Q., L.A.W.); Department of Physiology, Faculty of Medicine, McGill University, Montréal, Canada (D.F.Q.); Department of Medicine, Division of Experimental Medicine, McGill University, Montréal, Canada (D.F.Q.); Department of Human Genetics, McGill University, Montréal, Canada (L.A.W.); and Sainte-Justine University Hospital Research Centre, Montréal, Canada (M.C.)., Fiset B; Department of Mathematics and Statistics, Université de Montréal, Montréal, Canada (A.S., M.C.); Centre de recherches mathématiques, Montréal, Canada (A.S.); School of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia (A.L.J.); Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Canada (E.K., B.F., D.F.Q., L.A.W.); Department of Physiology, Faculty of Medicine, McGill University, Montréal, Canada (D.F.Q.); Department of Medicine, Division of Experimental Medicine, McGill University, Montréal, Canada (D.F.Q.); Department of Human Genetics, McGill University, Montréal, Canada (L.A.W.); and Sainte-Justine University Hospital Research Centre, Montréal, Canada (M.C.)., Quail DF; Department of Mathematics and Statistics, Université de Montréal, Montréal, Canada (A.S., M.C.); Centre de recherches mathématiques, Montréal, Canada (A.S.); School of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia (A.L.J.); Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Canada (E.K., B.F., D.F.Q., L.A.W.); Department of Physiology, Faculty of Medicine, McGill University, Montréal, Canada (D.F.Q.); Department of Medicine, Division of Experimental Medicine, McGill University, Montréal, Canada (D.F.Q.); Department of Human Genetics, McGill University, Montréal, Canada (L.A.W.); and Sainte-Justine University Hospital Research Centre, Montréal, Canada (M.C.)., Walsh LA; Department of Mathematics and Statistics, Université de Montréal, Montréal, Canada (A.S., M.C.); Centre de recherches mathématiques, Montréal, Canada (A.S.); School of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia (A.L.J.); Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Canada (E.K., B.F., D.F.Q., L.A.W.); Department of Physiology, Faculty of Medicine, McGill University, Montréal, Canada (D.F.Q.); Department of Medicine, Division of Experimental Medicine, McGill University, Montréal, Canada (D.F.Q.); Department of Human Genetics, McGill University, Montréal, Canada (L.A.W.); and Sainte-Justine University Hospital Research Centre, Montréal, Canada (M.C.)., Craig M; Department of Mathematics and Statistics, Université de Montréal, Montréal, Canada (A.S., M.C.); Centre de recherches mathématiques, Montréal, Canada (A.S.); School of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia (A.L.J.); Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Canada (E.K., B.F., D.F.Q., L.A.W.); Department of Physiology, Faculty of Medicine, McGill University, Montréal, Canada (D.F.Q.); Department of Medicine, Division of Experimental Medicine, McGill University, Montréal, Canada (D.F.Q.); Department of Human Genetics, McGill University, Montréal, Canada (L.A.W.); and Sainte-Justine University Hospital Research Centre, Montréal, Canada (M.C.) morgan.craig@umontreal.ca.

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2023 Oct; Vol. 387 (1), pp. 66-77. Date of Electronic Publication: 2023 Jul 13.