Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Quaid Morris"'
Autor:
Elena Kuzmin, Toby M. Baker, Tom Lesluyes, Jean Monlong, Kento T. Abe, Paula P. Coelho, Michael Schwartz, Joseph Del Corpo, Dongmei Zou, Genevieve Morin, Alain Pacis, Yang Yang, Constanza Martinez, Jarrett Barber, Hellen Kuasne, Rui Li, Mathieu Bourgey, Anne-Marie Fortier, Peter G. Davison, Atilla Omeroglu, Marie-Christine Guiot, Quaid Morris, Claudia L. Kleinman, Sidong Huang, Anne-Claude Gingras, Jiannis Ragoussis, Guillaume Bourque, Peter Van Loo, Morag Park
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113988- (2024)
Summary: The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize evolution and maintenance of chromosome 4p (chr4p) loss in basal breast cancer. A
Externí odkaz:
https://doaj.org/article/037f03f6925f4a5d977165ac992225f6
Autor:
Debashish Ray, Kaitlin U. Laverty, Arttu Jolma, Kate Nie, Reuben Samson, Sara E. Pour, Cyrus L. Tam, Niklas von Krosigk, Syed Nabeel-Shah, Mihai Albu, Hong Zheng, Gabrielle Perron, Hyunmin Lee, Hamed Najafabadi, Benjamin Blencowe, Jack Greenblatt, Quaid Morris, Timothy R. Hughes
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Thousands of RNA-binding proteins (RBPs) crosslink to cellular mRNA. Among these are numerous unconventional RBPs (ucRBPs)—proteins that associate with RNA but lack known RNA-binding domains (RBDs). The vast majority of ucRBPs have unchara
Externí odkaz:
https://doaj.org/article/1bc102f75ce84e278ddced7e0d6825bd
Autor:
Abdurrahman Elbasir, Ying Ye, Daniel E. Schäffer, Xue Hao, Jayamanna Wickramasinghe, Konstantinos Tsingas, Paul M. Lieberman, Qi Long, Quaid Morris, Rugang Zhang, Alejandro A. Schäffer, Noam Auslander
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Here, Elbasir et al. develop viRNAtrap, a deep learning approach for detection of viruses from tumor RNA sequencing data, which they showcase on an RNA dataset of different cancer types, revealing tumor expression of divergent viruses that had not be
Externí odkaz:
https://doaj.org/article/421e42058eca41a19dcd684464f627fa
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 12, p e1010733 (2022)
Cancer genomes harbor a catalog of somatic mutations. The type and genomic context of these mutations depend on their causes and allow their attribution to particular mutational signatures. Previous work has shown that mutational signature activities
Externí odkaz:
https://doaj.org/article/74cf33fa231544038a08ee6674f0d92d
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101706- (2022)
Summary: Pairtree is a clone tree reconstruction algorithm that uses somatic point mutations to build clone trees describing the evolutionary history of individual cancers. Using the Pairtree software package, we describe steps to preprocess somatic
Externí odkaz:
https://doaj.org/article/5120ad9456f247bd96aaf353cfc31401
Autor:
Kimberly Skead, Armande Ang Houle, Sagi Abelson, Mawusse Agbessi, Vanessa Bruat, Boxi Lin, David Soave, Liran Shlush, Stephen Wright, John Dick, Quaid Morris, Philip Awadalla
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Age-related clonal hematopoiesis is associated with risk for diseases like acute myeloid leukemia (AML), yet it is unclear why some individuals do not progress despite having AML driver mutations. Here, the authors use deep learning and population ge
Externí odkaz:
https://doaj.org/article/1395e2a4d71f41359ea4b5086c1ffbe6
Differential contribution of transcriptomic regulatory layers in the definition of neuronal identity
Autor:
Kevin C. H. Ha, Timothy Sterne-Weiler, Quaid Morris, Robert J. Weatheritt, Benjamin J. Blencowe
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Post-transcriptional gene regulation is an important contributor to cell type-specific differences at the transcriptomic level. Here, the authors use a multiomics approach to characterize neuronal diversity in the mouse nervous system, analyzing the
Externí odkaz:
https://doaj.org/article/ceac70d961764ae2880fc4ec471358e9
Autor:
Thomas Spruce, Mireya Plass, André Gohr, Debashish Ray, María Martínez de Lagrán, Gregor Rot, Ana Nóvoa, Demian Burguera, Jon Permanyer, Marta Miret, Hong Zheng, Maurice S Swanson, Quaid Morris, Moises Mallo, Mara Dierssen, Timothy R Hughes, Barbara Pernaute, Manuel Irimia
Publikováno v:
PLoS Biology, Vol 20, Iss 4, p e3001615 (2022)
Understanding the regulatory interactions that control gene expression during the development of novel tissues is a key goal of evolutionary developmental biology. Here, we show that Mbnl3 has undergone a striking process of evolutionary specializati
Externí odkaz:
https://doaj.org/article/123842fa9e434a1097df0caff61e1e6d
Autor:
Wei Jiao, Gurnit Atwal, Paz Polak, Rosa Karlic, Edwin Cuppen, PCAWG Tumor Subtypes and Clinical Translation Working Group, Alexandra Danyi, Jeroen de Ridder, Carla van Herpen, Martijn P. Lolkema, Neeltje Steeghs, Gad Getz, Quaid Morris, Lincoln D. Stein, PCAWG Consortium
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer base
Externí odkaz:
https://doaj.org/article/1eb66053b1d54801a9b93093526fbf22
Autor:
Yulia Rubanova, Ruian Shi, Caitlin F. Harrigan, Roujia Li, Jeff Wintersinger, Nil Sahin, Amit Deshwar, PCAWG Evolution and Heterogeneity Working Group, Quaid Morris, PCAWG Consortium
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mu
Externí odkaz:
https://doaj.org/article/1a3e0a924fa54deda33cd083d4a87624