Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Quadri Adewale"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Typical differential single-nucleus gene expression (snRNA-seq) analyses in Alzheimer’s disease (AD) provide fixed snapshots of cellular alterations, making the accurate detection of temporal cell changes challenging. To characterize the d
Externí odkaz:
https://doaj.org/article/0a8695f9924f407dabb198b8d280a168
Autor:
Lazaro M. Sanchez-Rodriguez, Ahmed F. Khan, Quadri Adewale, Gleb Bezgin, Joseph Therriault, Jaime Fernandez-Arias, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Jenna Stevenson, Hongxiu Jiang, Xiaoqian Chai, Felix Carbonell, Pedro Rosa-Neto, Yasser Iturria-Medina
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
The molecular mechanisms underlying neuronal dysfunction in Alzheimer’s disease (AD) remain uncharacterized. Here, we identify genes, molecular pathways and cellular components associated with whole-brain dysregulation caused by amyloid-beta (Aβ)
Externí odkaz:
https://doaj.org/article/1657c77c5c334d1eb95796dc2572b831
Autor:
Veronika Pak, Quadri Adewale, Danilo Bzdok, Mahsa Dadar, Yashar Zeighami, Yasser Iturria-Medina
Publikováno v:
eLife, Vol 12 (2024)
For over a century, brain research narrative has mainly centered on neuron cells. Accordingly, most neurodegenerative studies focus on neuronal dysfunction and their selective vulnerability, while we lack comprehensive analyses of other major cell ty
Externí odkaz:
https://doaj.org/article/c91a0051471f4d7aa892e4c6b81ff5ff
Autor:
Ahmed Faraz Khan, Quadri Adewale, Sue-Jin Lin, Tobias R. Baumeister, Yashar Zeighami, Felix Carbonell, Nicola Palomero-Gallagher, Yasser Iturria-Medina
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Parkinson’s disease involves multiple neurotransmitter systems beyond the classical dopaminergic circuit, but their influence on structural and functional alterations is not well understood. Here, we use patient-specific causal brain model
Externí odkaz:
https://doaj.org/article/99f9f45ced0d425fbc90cae72e8a2585
Autor:
Yasser Iturria-Medina, Félix Carbonell, Atousa Assadi, Quadri Adewale, Ahmed F. Khan, Tobias R. Baumeister, Lazaro Sanchez-Rodriguez
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-20 (2021)
Iturria-Medina et al. demonstrate the validation of NeuroPM-box — an open-access, multi-tool cross-platform software that can characterize multiscale and multifactorial neuropathological mechanisms. Their tool potentially contributes to a better un
Externí odkaz:
https://doaj.org/article/82be0689e13e456c93524cb325ee326b
Autor:
Quadri Adewale, Ahmed F Khan, Felix Carbonell, Yasser Iturria-Medina, Alzheimer's Disease Neuroimaging Initiative
Publikováno v:
eLife, Vol 10 (2021)
Both healthy aging and Alzheimer’s disease (AD) are characterized by concurrent alterations in several biological factors. However, generative brain models of aging and AD are limited in incorporating the measures of these biological factors at dif
Externí odkaz:
https://doaj.org/article/50ab6f8e5f6e41f7a87efcd0923fe990
Autor:
Ahmed Faraz Khan, Quadri Adewale, Sue-Jin Lin, Tobias R. Baumeister, Yashar Zeighami, Felix Carbonell, Nicola Palomero-Gallagher, Yasser Iturria-Medina
Multi-systemic neurodegeneration in Parkinson’s disease (PD) is increasingly acknowledged, involving several neurotransmitter systems beyond the classical dopaminergic circuit and resulting in heterogeneous motor and non-motor symptoms. Nevertheles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::534208a5fee6c8309845019433629f51
https://doi.org/10.1101/2023.03.22.23287578
https://doi.org/10.1101/2023.03.22.23287578
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f72e4e6f1a11c90575c520b734e0c196
https://doi.org/10.1002/alz.065508
https://doi.org/10.1002/alz.065508
Autor:
Yasser Iturria-Medina, Quadri Adewale, Ahmed F. Khan, Simon Ducharme, Pedro Rosa-Neto, Kieran O’Donnell, Vladislav A. Petyuk, Serge Gauthier, Philip L. De Jager, John Breitner, David A. Bennett
Publikováno v:
Science advances. 8(46)
Alzheimer’s disease (AD) is a heterogeneous disorder with abnormalities in multiple biological domains. In an advanced machine learning analysis of postmortem brain and in vivo blood multi-omics molecular data ( N = 1863), we integrated epigenomic,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b2d4fc0129c73a2bf97c5b65412ece
https://pubmed.ncbi.nlm.nih.gov/36399579
https://pubmed.ncbi.nlm.nih.gov/36399579
To characterize the dynamic genetic and cellular differences in AD neuropathology, we apply the novel concept of RNA velocity to the study of single-nucleus RNA from the cortex of 60 subjects with varied levels of AD pathology. RNA velocity captures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9e2ce80c76ad4044a8266201636fc2f
https://doi.org/10.1101/2022.10.31.22281759
https://doi.org/10.1101/2022.10.31.22281759