Zobrazeno 1 - 10
of 285
pro vyhledávání: '"Qu Tian"'
Autor:
Keenan A. Walker, Yang An, Abhay Moghekar, Ruin Moaddel, Michael R. Duggan, Zhongsheng Peng, Qu Tian, Luke C. Pilling, Shannon M. Drouin, Mark A. Espeland, Stephen R Rapp, Kathleen M Hayden, Aladdin H. Shadyab, Ramon Casanova, Madhav Thambisetty, Peter R. Rapp, Dimitrios Kapogiannis, Luigi Ferrucci, Susan M. Resnick
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-18 (2024)
Abstract Background Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease (AD). This case-cohort study used targeted plasma biomarkers and large-scale proteomics to examine the biological mechani
Externí odkaz:
https://doaj.org/article/ee7fd18cf0994326a5954b2b904a2e34
Autor:
Paola Sebastiani, Stefano Monti, Michael S. Lustgarten, Zeyuan Song, Dylan Ellis, Qu Tian, Michaela Schwaiger-Haber, Ethan Stancliffe, Anastasia Leshchyk, Meghan I. Short, Andres V. Ardisson Korat, Anastasia Gurinovich, Tanya Karagiannis, Mengze Li, Hannah J. Lords, Qingyan Xiang, Megan M. Marron, Harold Bae, Mary F. Feitosa, Mary K. Wojczynski, Jeffrey R. O’Connell, May E. Montasser, Nicole Schupf, Konstantin Arbeev, Anatoliy Yashin, Nicholas Schork, Kaare Christensen, Stacy L. Andersen, Luigi Ferrucci, Noa Rappaport, Thomas T. Perls, Gary J. Patti
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114913- (2024)
Summary: Metabolites that mark aging are not fully known. We analyze 408 plasma metabolites in Long Life Family Study participants to characterize markers of age, aging, extreme longevity, and mortality. We identify 308 metabolites associated with ag
Externí odkaz:
https://doaj.org/article/c744c40c4a184bd995de8390a0fca998
Autor:
Chenxin Tian, Jennifer A. Schrack, Yuri Agrawal, Yang An, Yurun Cai, Hang Wang, Alden L. Gross, Qu Tian, Eleanor M. Simonsick, Luigi Ferrucci, Susan M. Resnick, Amal A. Wanigatunga
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Sensory impairment and brain atrophy is common among older adults, increasing the risk of dementia. Yet, the degree to which multiple co-occurring sensory impairments (MSI across vision, proprioception, vestibular function, olfactory, and he
Externí odkaz:
https://doaj.org/article/50297d47b7dc4729ac1f3b7bf27f8a3b
Autor:
Francesco Casanova, Qu Tian, Daniel S. Williamson, Yong Qian, David Zweibaum, Jun Ding, Janice L. Atkins, David Melzer, Luigi Ferrucci, Luke C. Pilling
Publikováno v:
Neurobiology of Disease, Vol 197, Iss , Pp 106539- (2024)
Background: Iron overload is observed in neurodegenerative diseases, especially Alzheimer's disease (AD) and Parkinson's disease (PD). Homozygotes for the iron-overload (haemochromatosis) causing HFE p.C282Y variant have increased risk of dementia an
Externí odkaz:
https://doaj.org/article/0301ea7a15fa41d9878d92107d865ee1
Autor:
Qu Tian, Philip R. Lee, Qi Yang, Anne Z. Moore, Bennett A. Landman, Susan M. Resnick, Luigi Ferrucci
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 1, Pp 138-148 (2024)
Abstract Background Mitochondrial dysfunction may contribute to brain and muscle health through inflammation or fat infiltration in the muscle, both of which are associated with cognitive function and mobility. We aimed to examine the association bet
Externí odkaz:
https://doaj.org/article/7029d685323c402b8766e254cc90e490
Autor:
Ryan J. Dougherty, Amal A. Wanigatunga, Yang An, Qu Tian, Eleanor M. Simonsick, Marilyn S. Albert, Susan M. Resnick, Jennifer A. Schrack
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 4, Pp n/a-n/a (2023)
Abstract INTRODUCTION White matter hyperintensities (WMHs) increase with age and contribute to cognitive and motor function decline. Energy costs for mobility worsen with age, as the energetic cost of walking increases and energetic capacity declines
Externí odkaz:
https://doaj.org/article/3c5534a9f1e84c34ba6f6b72fe742d25
Autor:
Yurun Cai, Jennifer A. Schrack, Alden L. Gross, Nicole M. Armstrong, Bonnielin K. Swenor, Jennifer A. Deal, Frank R. Lin, Hang Wang, Qu Tian, Yang An, Eleanor M. Simonsick, Luigi Ferrucci, Susan M. Resnick, Yuri Agrawal
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 2, Pp n/a-n/a (2023)
Abstract INTRODUCTION Sensory impairment (SI) is linked to cognitive decline, but its association with early cognitive impairment (ECI) is unclear. METHODS Sensory functions (vision, hearing, vestibular function, proprioception, and olfaction) were m
Externí odkaz:
https://doaj.org/article/baeb7144a7ea4b39b246c0499cc7e655
Autor:
Yujia Qiao, Amal A. Wanigatunga, Yang An, Fangyu Liu, Adam P. Spira, Christos Davatzikos, Qu Tian, Eleanor M. Simonsick, Luigi Ferrucci, Susan M. Resnick, Jennifer A. Schrack
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Peak energy capacity of the whole person is associated with neurodegeneration. However, change in ability to utilize energy manifests as combination of declining peak energy capacity and rising energetic costs of mobility in mid-to-late life
Externí odkaz:
https://doaj.org/article/f8ff7cb427af4b3f90b041c3d8e134b6
Autor:
Qu Tian, M. Gordian Adam, Enrique Ozcariz, Giovanna Fantoni, Nader M. Shehadeh, Lisa M. Turek, Victoria L. Collingham, Mary Kaileh, Ruin Moaddel, Luigi Ferrucci
Publikováno v:
Metabolites, Vol 13, Iss 5, p 591 (2023)
As one of the OMICS in systems biology, metabolomics defines the metabolome and simultaneously quantifies numerous metabolites that are final or intermediate products and effectors of upstream biological processes. Metabolomics provides accurate info
Externí odkaz:
https://doaj.org/article/346c60fa9aba44c7b85fce58c02c9c0b
Publikováno v:
工程科学学报, Vol 41, Iss 10, Pp 1280-1287 (2019)
In steelmaking process, nonmetallic inclusions are often considered to be detrimental to the mechanical properties and product quality of steel as they influence the microstructure of the steel matrix to a large extent, and thus, much industrial effo
Externí odkaz:
https://doaj.org/article/af04c9f69de34d44a3c83583c493509d