Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Qizhu Tang"'
Autor:
Chunyan Kong, Zhen Guo, Fangyuan Liu, Nan Tang, Mingyu Wang, Dan Yang, Chenfei Li, Zheng Yang, Yulan Ma, Pan Wang, Qizhu Tang
Publikováno v:
Journal of Advanced Research, Vol 61, Iss , Pp 65-81 (2024)
Introduction: Targeted protein degradation represents a promising therapeutic approach, while diabetic cardiomyopathy (DCM) arises as a consequence of aberrant insulin secretion and impaired glucose and lipid metabolism in the heart.. Objectives: Con
Externí odkaz:
https://doaj.org/article/b7973a7545b449a0afca880389f00bcb
Autor:
Hongliang Qiu, Sihui Huang, Yuting Liu, Libo Liu, Fengming Guo, Yingying Guo, Dan Li, Xianfeng Cen, Yajie Chen, Meng Zhang, Yan Che, Man Xu, Qizhu Tang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 6, Pp 2581-2597 (2024)
Doxorubicin (DOX)-mediated cardiotoxicity can exacerbate mortality in oncology patients, but related pharmacotherapeutic measures are relatively limited. Ferroptosis was recently identified as a major mechanism of DOX-induced cardiotoxicity. Idebenon
Externí odkaz:
https://doaj.org/article/dfe8996f856d4f6dbc399a77398b3539
Publikováno v:
PeerJ, Vol 12, p e18135 (2024)
Background This study aims to identify a novel gene signature for coronary artery disease (CAD), explore the role of immune cell infiltration in CAD pathogenesis, and assess the cell function of mast cell-expressed membrane protein 1 (MCEMP1) in huma
Externí odkaz:
https://doaj.org/article/17c286fd23554de3abacffbffe2ede78
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 689 (2024)
Reactive oxygen species (ROSs) are byproducts of normal cellular metabolism and play pivotal roles in various physiological processes. Disruptions in the balance between ROS levels and the body’s antioxidant defenses can lead to the development of
Externí odkaz:
https://doaj.org/article/25aa2880ebb9490ba962a1cd70217e83
Autor:
Yizhou Feng, Yuan Yuan, Hongxia Xia, Zhaopeng Wang, Yan Che, Zhefu Hu, Jiangyang Deng, Fangfang Li, Qingqing Wu, Zhouyan Bian, Heng Zhou, Difei Shen, Qizhu Tang
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-20 (2023)
Abstract Background Oncostatin M (OSM) is a secreted cytokine of the interleukin (IL)-6 family that induces biological effects by activating functional receptor complexes of the common signal transducing component glycoprotein 130 (gp130) and OSM rec
Externí odkaz:
https://doaj.org/article/694e59a5294c4ff5ad06033fc099e10b
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-20 (2023)
Abstract Cardiac aging is evident by a reduction in function which subsequently contributes to heart failure. The metabolic microenvironment has been identified as a hallmark of malignancy, but recent studies have shed light on its role in cardiovasc
Externí odkaz:
https://doaj.org/article/cd3ca37d1d354df5a4ce4de885f54503
Autor:
Saiyang Xie, Yun Xing, Wenke Shi, Min Zhang, Mengya Chen, Wenxi Fang, Shiqiang Liu, Tong Zhang, Xiaofeng Zeng, Si Chen, Shasha Wang, Wei Deng, Qizhu Tang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 11, Pp 4138-4153 (2022)
Despite complications were significantly reduced due to the popularity of percutaneous coronary intervention (PCI) in clinical trials, reperfusion injury and chronic cardiac remodeling significantly contribute to poor prognosis and rehabilitation in
Externí odkaz:
https://doaj.org/article/4fea733bc4714894b65e57ebb8c12940
Autor:
Saiyang Xie, Mengya Chen, Wenxi Fang, Shiqiang Liu, Qingqing Wu, Chen Liu, Yun Xing, Wenke Shi, Man Xu, Min Zhang, Si Chen, Xiaofeng Zeng, Shasha Wang, Wei Deng, Qizhu Tang
Publikováno v:
EBioMedicine, Vol 86, Iss , Pp 104359- (2022)
Summary: Background: Arachidonate 5-lipoxygenase (Alox5) belongs to a class of nonheme iron-containing dioxygenases involved in the catalysis of leukotriene biosynthesis. However, the effects of Alox5 itself on pathological cardiac remodeling and hea
Externí odkaz:
https://doaj.org/article/598ce4418921495dbe7e08e08ec204d3
Autor:
Saiyang Xie, Min Zhang, Wenke Shi, Yun Xing, Yan Huang, Wen‐xi Fang, Shi‐qiang Liu, Meng‐Ya Chen, Tong Zhang, Si Chen, Xiaofeng Zeng, Shasha Wang, Wei Deng, Qizhu Tang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 19 (2022)
Background Mechanistic insights of glucagon‐like peptide‐1 receptor agonists remain incompletely identified, despite the efficacy in heart failure observed in clinical trials. Here, we evaluated the effects of dulaglutide on heart complications a
Externí odkaz:
https://doaj.org/article/cb0682fc7e2b429494f2716612ead506
Autor:
Min Zhang, Li Wei, Saiyang Xie, Yun Xing, Wenke Shi, Xiaofeng Zeng, Si Chen, Shasha Wang, Wei Deng, Qizhu Tang
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: As a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, lithospermic acid (LA) has been identified as the pharmacological management for neuroprotection and hepatoprotection. However, the role and mechani
Externí odkaz:
https://doaj.org/article/98fe9b35e9cd43eb9ebf58f6fd0ba930