Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Qizhen Shi"'
Autor:
June Li, Danielle Karakas, Feng Xue, Yingyu Chen, Guangheng Zhu, Yeni H. Yucel, Sonya A. MacParland, Haibo Zhang, John W. Semple, John Freedman, Qizhen Shi, Heyu Ni
Publikováno v:
Research, Vol 6 (2023)
Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. However, the anti-inflammatory/immunosuppressive potential of pla
Externí odkaz:
https://doaj.org/article/d855d9b595ef481e9037018204a124a5
Autor:
Liping Luo, Qiaoyun Zheng, Zhenyu Chen, Meijuan Huang, Lin Fu, Jianda Hu, Qizhen Shi, Yingyu Chen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The development of coagulation factor VIII (FVIII) inhibitory antibodies is a serious complication in hemophilia A (HA) patients after FVIII replacement therapy. Inhibitors render regular prophylaxis ineffective and increase the risk of morbidity and
Externí odkaz:
https://doaj.org/article/5bd8fcbe085c4740a01e7c364319c1fb
Autor:
Yuanhua Cai, Jocelyn A. Schroeder, Weiqing Jing, Cody Gurski, Calvin B. Williams, Shaoyuan Wang, Bonnie N. Dittel, Qizhen Shi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system with no cure yet. Here, we report genetic engineering of hematopoietic stem cells (HSCs) to express myelin oligodendrocyte glycoprotein (MOG), specific
Externí odkaz:
https://doaj.org/article/ec6a2fddd5f34326a50e945eeb517ef7
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 719-730 (2021)
While platelet-specific gene therapy is effective in inducing immune tolerance to a targeted protein, how the reactivity of pre-existing immunity affects the efficacy, and whether CD8 T cells were involved in tolerization, is unclear. In this study,
Externí odkaz:
https://doaj.org/article/6b892202126248749c94d0de8a61d1a6
Autor:
Yuwen Chen, Liping Luo, Yongzhi Zheng, Qiaoyun Zheng, Na Zhang, Donghui Gan, Shimuye Kalayu Yirga, Zhenxing Lin, Qizhen Shi, Lin Fu, Jianda Hu, Yingyu Chen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Thrombocytopenia is a multifactorial condition that frequently involves concomitant defects in platelet production and clearance. The physiopathology of low platelet count in thrombocytopenia remains unclear. Sialylation on platelet membrane glycopro
Externí odkaz:
https://doaj.org/article/1a632389f5584df0b5f37d8d1862a200
Autor:
Qizhen Shi, Jeremy G. Mattson, Scot A. Fahs, Aron M. Geurts, Hartmut Weiler, Robert R. Montgomery
Publikováno v:
Blood Advances, Vol 4, Iss 1, Pp 55-65 (2020)
Abstract: Previous studies have shown that platelet-specific factor VIII (FVIII) expression (2bF8) restores hemostasis and induces immune tolerance in hemophilia A (HA) mice even with preexisting inhibitors. Here we investigated for the first time wh
Externí odkaz:
https://doaj.org/article/4e3552c0479e4d4387e070fdcdf8f091
Autor:
Jessica Garcia, Veronica H. Flood, Sandra L. Haberichter, Scot A. Fahs, Jeremy G. Mattson, Aron M. Geurts, Mark Zogg, Hartmut Weiler, Qizhen Shi, Robert R. Montgomery
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 1, Pp 64-71 (2020)
Abstract Background Von Willebrand Disease (VWD) is the most common inherited bleeding disorder, caused by quantitative and qualitative changes in von Willebrand factor (VWF). The biology of VWD, studied in canine, porcine, and murine models, differ
Externí odkaz:
https://doaj.org/article/dfb6426d17994ee9ae5dbf1dce097efe
Autor:
Weiqing Jing, Juan Chen, Yuanhua Cai, Yingyu Chen, Jocelyn A. Schroeder, Bryon D. Johnson, Weiguo Cui, Qizhen Shi
Publikováno v:
Blood Advances, Vol 3, Iss 20, Pp 3099-3110 (2019)
Abstract: The development of neutralizing anti-FVIII antibodies (inhibitors) is a major complication of FVIII protein replacement therapy in patients with hemophilia A (HA). Although multiple lines of evidence indicate that the immune response agains
Externí odkaz:
https://doaj.org/article/538a91862d0c4f2abde43edc1239876f
Autor:
Chunyan Gao, Jocelyn A. Schroeder, Feng Xue, Weiqing Jing, Yuanhua Cai, Amelia Scheck, Saravanan Subramaniam, Sridhar Rao, Hartmut Weiler, Agnieszka Czechowicz, Qizhen Shi
Publikováno v:
Blood Advances, Vol 3, Iss 18, Pp 2700-2711 (2019)
Gene therapy offers the potential to cure hemophilia A (HA). We have shown that hematopoietic stem cell (HSC)–based platelet-specific factor VIII (FVIII) (2bF8) gene therapy can produce therapeutic protein and induce antigen-specific immune toleran
Externí odkaz:
https://doaj.org/article/83420e9f07c946c78fd2d34f6a0da735
Publikováno v:
Journal of Thrombosis and Haemostasis. 21:488-498
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8d847be60bb318b4e39c5dd17541ac7
https://doi.org/10.1016/j.jtha.2022.10.006
https://doi.org/10.1016/j.jtha.2022.10.006