Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Qiyin Zhou"'
Autor:
Qiyin Zhou, Wenyu Lin, Chaoqun Wang, Fei Sun, Siwei Ju, Qian Chen, Yi Wang, Yongxia Chen, Haomin Li, Linbo Wang, Zeping Hu, Hongchuan Jin, Xian Wang, Yi Sun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Neddylation inhibition has been reported as a therapy for cancer. Here, the authors show that neddylation inhibition increases glutamine metabolism by stabilizing glutamine transporter ASCT2, therefore targeting ASCT2 improves the anti-cancer effect
Externí odkaz:
https://doaj.org/article/5b5ddbc59fa9458e98897f0c628a4628
Autor:
Lifeng Feng, Miaoqin Chen, Yiling Li, Muchun Li, Shiman Hu, Bingluo Zhou, Liyuan Zhu, Lei Yu, Qiyin Zhou, Linghui Tan, Huimin An, Xian Wang, Hongchuan Jin
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-13 (2021)
Abstract p62/SQSTM1 is frequently up-regulated in many cancers including hepatocellular carcinoma. Highly expressed p62 promotes hepato-carcinogenesis by activating many signaling pathways including Nrf2, mTORC1, and NFκB signaling. However, the und
Externí odkaz:
https://doaj.org/article/41c6109649734104871764182ace81d2
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Mitochondria are the powerhouse of a cell. The structure and function of mitochondria are precisely regulated by multiple signaling pathways. Neddylation, a post-translational modification, plays a crucial role in various cellular processes
Externí odkaz:
https://doaj.org/article/209c04c0617045da91b9fdf61dc17e8a
Autor:
Ping Song, Lifeng Feng, Jiaqiu Li, Dongjun Dai, Liyuan Zhu, Chaoqun Wang, Jingyi Li, Ling Li, Qiyin Zhou, Rongkai Shi, Xian Wang, Hongchuan Jin
Publikováno v:
Molecular Cancer, Vol 19, Iss 1, Pp 1-15 (2020)
Abstract Background Heat shock transcription factor1 (HSF1) was overexpressed to promote glutaminolysis and activate mTOR in colorectal cancer (CRC). Here, we investigated the mechanism for cancer-specific overexpression of HSF1. Methods HSF1 express
Externí odkaz:
https://doaj.org/article/f42df6f7c86e479a960614ca3f8e110a
Autor:
Yiran Zhu, Bingluo Zhou, Xinyang Hu, Shilong Ying, Qiyin Zhou, Wenxia Xu, Lifeng Feng, Tianlun Hou, Xian Wang, Liyuan Zhu, Hongchuan Jin
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 1, Pp n/a-n/a (2022)
Abstract Background Chemoresistance to cisplatin (DDP) remains a major challenge in advanced gastric cancer (GC) treatment. Although accumulating evidence suggests an association between dysregulation of long non‐coding RNAs (lncRNAs) and chemoresi
Externí odkaz:
https://doaj.org/article/42735ef31de945189e6828e37270aeff
Autor:
Bingluo Zhou, Yiran Zhu, Wenxia Xu, Qiyin Zhou, Linghui Tan, Liyuan Zhu, Hui Chen, Lifeng Feng, Tianlun Hou, Xian Wang, Dingwei Chen, Hongchuan Jin
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Hypoxia is an important characteristic of the tumor microenvironment. Tumor cells can survive and propagate under the hypoxia stress by activating a series of adaption response. Herein, we found that lysine-specific demethylase 5B (KDM5B) was upregul
Externí odkaz:
https://doaj.org/article/d9054eaaf2f246e1809a2efa6baeb281
Autor:
Lifeng Feng, Muchun Li, Xinyang Hu, Yiling Li, Liyuan Zhu, Miaoqin Chen, Qi Wei, Wenxia Xu, Qiyin Zhou, Weikai Wang, Dingwei Chen, Xian Wang, Hongchuan Jin
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 10, Pp n/a-n/a (2021)
Abstract Chemoresistance remains a major obstacle to successful cancer therapy, especially for advanced cancers. It used to be recognised as a stable outcome resulting from genetic changes. However, recent studies showed that chemoresistance can also
Externí odkaz:
https://doaj.org/article/0e859d4b9c61470e9f235edfc56ecf03
Autor:
Qiyin Zhou, Wenyu Lin, Chaoqun Wang, Fei Sun, Siwei Ju, Qian Chen, Yi Wang, Yongxia Chen, Haomin Li, Linbo Wang, Zeping Hu, Hongchuan Jin, Xian Wang, Yi Sun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/f8dd880f3c374b349cb59130922c4d0a
Autor:
Qiyin Zhou, Yi Sun
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 5 (2019)
MLN4924, a small molecular inhibitor of NEDD8 (neuronal precursor cell-expressed developmentally downregulated protein 8) activating enzyme (NAE), blocks cullin neddylation to inactivate cullin-RING ligase. We found that MLN4924 has additional activi
Externí odkaz:
https://doaj.org/article/d029a068742443e48c52debdad28dcdc
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124200 (2015)
MTO1, together with MSS1 and MTO2, is a gene involved in the pathway of encoding a mitochondria-specific RNA-modifying enzyme related to the post-transcriptional modification of mitochondrial tRNAs. We have previously shown that a mutation of the MTO
Externí odkaz:
https://doaj.org/article/51e528d718fd4144b643c962f3bd80ee