Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Qiyao Chai"'
Publikováno v:
hLife, Vol 2, Iss 10, Pp 496-513 (2024)
The human microbiota, a diverse community of microorganisms living on or within their hosts, play an irreplaceable role in maintaining human health. Dysbiosis of the microbiota is associated with the pathogenesis of diverse human diseases. In recent
Externí odkaz:
https://doaj.org/article/074adf59311a4ef5be847c61e1654c2e
Autor:
Jing Wang, Qiyao Chai, Zehui Lei, Yiru Wang, Jiehua He, Pupu Ge, Zhe Lu, Lihua Qiang, Dongdong Zhao, Shanshan Yu, Changgen Qiu, Yanzhao Zhong, Bing-Xi Li, Lingqiang Zhang, Yu Pang, George Fu Gao, Cui Hua Liu
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 8, Pp 1755-1790 (2024)
Abstract Chronic infections, including Mycobacterium tuberculosis (Mtb)-caused tuberculosis (TB), can induce host immune exhaustion. However, the key checkpoint molecules involved in this process and the underlying regulatory mechanisms remain largel
Externí odkaz:
https://doaj.org/article/ae6f6b1e577e473187f3a8bfd0f24742
Autor:
Lihua Qiang, Yong Zhang, Zehui Lei, Zhe Lu, Shasha Tan, Pupu Ge, Qiyao Chai, Mengyuan Zhao, Xinwen Zhang, Bingxi Li, Yu Pang, Lingqiang Zhang, Cui Hua Liu, Jing Wang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Ferroptosis is an iron-dependent form of cell death whose role in infectious diseases is being elucidated. Here, Qiang et al. show that PtpA, an effector secreted by Mycobacterium tuberculosis, induces ferroptosis by hijacking host arginine methyltra
Externí odkaz:
https://doaj.org/article/405c017846364b8bbadd2726bef8588d
Autor:
Mengyuan Zhao, Yong Zhang, Lihua Qiang, Zhe Lu, Zhuo Zhao, Yesheng Fu, Bo Wu, Qiyao Chai, Pupu Ge, Zehui Lei, Xinwen Zhang, Bingxi Li, Jing Wang, Lingqiang Zhang, Cui Hua Liu
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112655- (2023)
Summary: The regulation of antiviral immunity is crucial in maintaining host immune homeostasis, a process that involves dynamic modulations of host organelles. The Golgi apparatus is increasingly perceived as a host organelle functioning as a critic
Externí odkaz:
https://doaj.org/article/1abfb1d7784f4823bb443206c12e36eb
Autor:
Qiyao Chai, Xudong Wang, Lihua Qiang, Yong Zhang, Pupu Ge, Zhe Lu, Yanzhao Zhong, Bingxi Li, Jing Wang, Lingqiang Zhang, Dawang Zhou, Wei Li, Wenzhu Dong, Yu Pang, George Fu Gao, Cui Hua Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Ubiquitin (Ub)-mediated xenophagy is important in defense against Mycobacterium tuberculosis (Mtb). Here, Chai et al. describe autophagy triggering by Ub binding to the Mtb surface protein Rv1468c, and show that its deletion leads to increased bacter
Externí odkaz:
https://doaj.org/article/74d2a3ea423348b2880c9a031a9391b8
Autor:
Jing Wang, Pupu Ge, Lihua Qiang, Feng Tian, Dongdong Zhao, Qiyao Chai, Mingzhao Zhu, Rongbin Zhou, Guangxun Meng, Yoichiro Iwakura, George Fu Gao, Cui Hua Liu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Mycobacterium tuberculosis secretes a protein, PtpA, that dephosphorylates proteins in the host cell cytoplasm, weakening immune responses. Here, the authors show that PtpA also enters the nucleus, affects the expression of several host genes, and pr
Externí odkaz:
https://doaj.org/article/465a63bc5e6745cab574ea4a454e9961
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB), is an extremely successful pathogen that adapts to survive within the host. During the latency phase of infection, M. tuberculosis employs a range of effector proteins to be clou
Externí odkaz:
https://doaj.org/article/c38bf3260a204b5a81ab90e6c99137e6
Autor:
Jing Wang, Dongdong Zhao, Zehui Lei, Pupu Ge, Zhe Lu, Qiyao Chai, Yong Zhang, Lihua Qiang, Yang Yu, Xinwen Zhang, Bingxi Li, Shu Zhu, Lingqiang Zhang, Cui Hua Liu
Publikováno v:
Cellular & Molecular Immunology. 20:158-174
Dysregulation of gut homeostasis is associated with irritable bowel syndrome (IBS), a chronic functional gastrointestinal disorder affecting approximately 11.2% of the global population. The poorly understood pathogenesis of IBS has impeded its treat
Autor:
Qiyao Chai, Cuihua Liu
Publikováno v:
Chinese Science Bulletin. 67:4309-4311
Autor:
Qiyao Chai, Shanshan Yu, Yanzhao Zhong, Zhe Lu, Changgen Qiu, Yang Yu, Xinwen Zhang, Yong Zhang, Zehui Lei, Lihua Qiang, Bing-Xi Li, Yu Pang, Xiao-Bo Qiu, Jing Wang, Cui Hua Liu
Publikováno v:
Science (New York, N.Y.). 378(6616)
The inflammasome-mediated cleavage of gasdermin D (GSDMD) causes pyroptosis and inflammatory cytokine release to control pathogen infection, but how pathogens evade this immune response remains largely unexplored. Here we identify the known protein p