Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Qixu Cai"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4969 (2024)
Tau protein misfolding and aggregation are pathological hallmarks of Alzheimer’s disease and over twenty neurodegenerative disorders. However, the molecular mechanisms of tau aggregation in vivo remain incompletely understood. There are two types o
Externí odkaz:
https://doaj.org/article/20a5252a2f134f69ab6b4242777fc4ee
Autor:
Yanyan Geng, Qixu Cai
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are progressive neurological disorders that share neurodegenerative pathways and features. The most prevalent genetic causes of ALS/FTD is the GGGGCC hexanucleotide repeat expansio
Externí odkaz:
https://doaj.org/article/c5240fa567794a72a767436c072e382b
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112146- (2023)
Summary: Calcium calmodulin-dependent kinase II (CaMKII) is critical for synaptic transmission and plasticity. Two major isoforms of CaMKII, CaMKIIα and CaMKIIβ, play distinct roles in synaptic transmission and long-term potentiation (LTP) with unk
Externí odkaz:
https://doaj.org/article/965a373f4a1848d2bcecd42d150388d7
Publikováno v:
eLife, Vol 10 (2021)
A large number of inhibitory receptors recruit SHP1 and/or SHP2, tandem-SH2-containing phosphatases through phosphotyrosine-based motifs immunoreceptor tyrosine-based inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM). Desp
Externí odkaz:
https://doaj.org/article/1a356497723b4fa1bd2c40c892beaad4
Autor:
Wenhe Zhong, Liang Cui, Boon Chong Goh, Qixu Cai, Peiying Ho, Yok Hian Chionh, Meng Yuan, Abbas El Sahili, Linda A. Fothergill-Gilmore, Malcolm D. Walkinshaw, Julien Lescar, Peter C. Dedon
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Pyruvate kinase (PYK) controls glycolytic flux. Here, the authors combine biochemical, structural and computational modelling studies to characterize the allosteric mechanisms regulating Mycobacterium tuberculosis PYK activity and show that AMP and g
Externí odkaz:
https://doaj.org/article/1ccbb8a01a5d4d8c9f866502136c19e3
Autor:
Yingying Zhang, Sheng Sean Su, Shubo Zhao, Zhentao Yang, Chuan-Qi Zhong, Xin Chen, Qixu Cai, Zhang-Hua Yang, Deli Huang, Rui Wu, Jiahuai Han
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Mitochondrial reactive oxygen species (ROS) promote necroptosis and the receptor interacting protein 1 (RIP1) is a key player in this form of cell death. Here, the authors show that cysteine residues in RIP1 sense ROS and oxidation of the cysteines t
Externí odkaz:
https://doaj.org/article/b6b6ee1e3fe44299866d7ced81989a55
Autor:
Xiumin Chen, Qixu Cai, Jing Zhou, Pleasure, Samuel J., Schulman, Howard, Mingjie Zhang, Nicoll, Roger A.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 6/25/2024, Vol. 121 Issue 26, p1-11, 16p
Autor:
Naining Xu, Ning Li, To To Choy, Pei-Yuan Qian, Haitao Miao, Zhipu Luo, Guang Zhu, Xiao Shi, Bo Zhou, Qixu Cai, Changdong Liu, Chun Po Fung, Yanyan Geng, Bing Yan
Publikováno v:
Nucleic Acids Research
The hexanucleotide repeat expansion, GGGGCC (G4C2), within the first intron of the C9orf72 gene is known to be the most common genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The G4C2 repeat expansions, ei
Publikováno v:
Developmental Cell. 55:18-29
Formation of biomolecular condensates that are not enclosed by membranes via liquid-liquid phase separation (LLPS) is a general strategy that cells adopt to organize membraneless subcellular compartments for diverse functions. Neurons are highly pola
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
A large number of inhibitory receptors recruit SHP1 and/or SHP2, tandem-SH2-containing phosphatases through phosphotyrosine-based motifs immunoreceptor tyrosine-based inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM). Desp