Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Qiuyun Dai"'
Autor:
Jinqin Chen, Xinhong Liu, Shuo Yu, Jia Liu, Rongfang Chen, Yunxiao Zhang, Ling Jiang, Qiuyun Dai
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2685-2693 (2021)
ω-Conotoxins inhibit N-type voltage-gated calcium (CaV2.2) channels and exhibit efficacy in attenuating neuropathic pain but have a low therapeutic index. Here, we synthesized and characterized a novel ω-conotoxin, Bu8 from Conus bullatus, which co
Externí odkaz:
https://doaj.org/article/a70fd78ef1424fb7afa9c9006cddbd6a
Autor:
Shuo Wang, Peter Bartels, Cong Zhao, Arsalan Yousuf, Zhuguo Liu, Shuo Yu, Anuja R. Bony, Xiaoli Ma, Qin Dai, Ting Sun, Na Liu, Mengke Yang, Rilei Yu, Weihong Du, David J. Adams, Qiuyun Dai
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
A novel 4/8 subtype α-conotoxin, Vt1.27 (NCCMFHTCPIDYSRFNC-NH2), was identified from Conus vitulinus in the South China Sea by RACE methods. The peptide was synthesized and structurally characterized. Similar to other α-conotoxins that target neuro
Externí odkaz:
https://doaj.org/article/3b40fc49ed124c818c7fb0be3c511e37
Autor:
Yuanmei Wei, Min Zhang, Shuo Yu, Qiuyuan Huang, Rongfang Chen, Shujing Xu, Yue Huang, Yunzhou Yu, Ming Liao, Qiuyun Dai
Publikováno v:
Marine Drugs, Vol 20, Iss 12, p 750 (2022)
α-conotoxin AuIB is the only one of the 4/6 type α-conotoxins (α-CTxs) that inhibits the γ-aminobutyric acid receptor B (GABABR)-coupled N-type calcium channel (CaV2.2). To improve its inhibitory activity, a series of variants were synthesized an
Externí odkaz:
https://doaj.org/article/8ad90b33b8824ed3b997b98dd2ea4d1b
Autor:
Xiaoli Ma, Qiuyuan Huang, Shuo Yu, Shujing Xu, Yue Huang, Zhiming Zhao, Xinrong Xiao, Qiuyun Dai
Publikováno v:
Marine Drugs, Vol 19, Iss 12, p 705 (2021)
α-Conotoxins GI and MI belong to the 3/5 subfamily of α-conotoxins and potently inhibit muscular nicotinic acetylcholine receptors (nAChRs). To date, no 3/4- or 3/6-subfamily α-conotoxins have been reported to inhibit muscular nAChRs. In the prese
Externí odkaz:
https://doaj.org/article/dbd26027242742bf8c2a5c0c17a7893a
Autor:
Zhuguo Liu, Zheng Yu, Shuo Yu, Cui Zhu, Mingxin Dong, Wenxiang Mao, Jie Hu, Mary Prorok, Ruibin Su, Qiuyun Dai
Publikováno v:
Marine Drugs, Vol 19, Iss 1, p 44 (2021)
N-methyl-D-aspartate receptor (NMDAR) antagonists have been found to be effective to inhibit morphine dependence. However, the discovery of the selective antagonist for NMDAR GluN2B with low side-effects still remains challenging. In the present stud
Externí odkaz:
https://doaj.org/article/72582b77df38454ebfe1ebd2f86eed32
Publikováno v:
Marine Drugs, Vol 13, Iss 6, Pp 3259-3275 (2015)
In the present study, we synthesized and, structurally and functionally characterized a novel α4/7-conotoxin Mr1.7 (PECCTHPACHVSHPELC-NH2), which was previously identified by cDNA libraries from Conus marmoreus in our lab. The NMR solution structure
Externí odkaz:
https://doaj.org/article/a149808813ce4a259c535aff6ab86cf8
Autor:
Shuo Yu, Yumeng Li, Jinqin Chen, Yue Zhang, Xinling Tao, Qiuyun Dai, Yutian Wang, Shupeng Li, Mingxin Dong
Publikováno v:
Marine Drugs, Vol 17, Iss 5, p 286 (2019)
As the first in a new class of non-opioid drugs, ω-Conotoxin MVIIA was approved for the management of severe chronic pains in patients who are unresponsive to opioid therapy. Unfortunately, clinical application of MVIIA is severely limited due to it
Externí odkaz:
https://doaj.org/article/80e3f1a8ca76481fa9b16cbc9207dbac
Publikováno v:
Molecules, Vol 23, Iss 4, p 747 (2018)
Axitinib is an approved kinase inhibitor for the therapy of advanced metastatic renal cell carcinoma (RCC). It prevents angiogenesis, cellular adhesion, and induces apoptosis of cancer cells. Here, nine axitinib derivatives were designed by replacing
Externí odkaz:
https://doaj.org/article/28a90f9d794b43e7807b94528df3b482
Autor:
Jinqin Chen, Li Liang, Huying Ning, Fengtao Cai, Zhuguo Liu, Longxiao Zhang, Liangyi Zhou, Qiuyun Dai
Publikováno v:
Marine Drugs, Vol 16, Iss 4, p 112 (2018)
α-Conotoxins (α-CTxs) are small peptides composed of 11 to 20 amino acid residues with two disulfide bridges. Most of them potently and selectively target nicotinic acetylcholine receptor (nAChR) subtypes, and a few were found to inhibit the GABAB
Externí odkaz:
https://doaj.org/article/46615dcfcbfe440b89f3956c0c9bb41f
Publikováno v:
Toxins, Vol 9, Iss 8, p 235 (2017)
α-conotoxin GI, a short peptide toxin in the venom of Conus geographus, is composed of 13 amino acids and two disulfide bonds. It is the most toxic component of Conus geographus venom with estimated lethal doses of 0.029–0.038 mg/kg for humans. Th
Externí odkaz:
https://doaj.org/article/eab037feb58a4c778ec1b48ebcd2b5d2