Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Qiuyun Dai"'
Autor:
Jinqin Chen, Xinhong Liu, Shuo Yu, Jia Liu, Rongfang Chen, Yunxiao Zhang, Ling Jiang, Qiuyun Dai
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2685-2693 (2021)
ω-Conotoxins inhibit N-type voltage-gated calcium (CaV2.2) channels and exhibit efficacy in attenuating neuropathic pain but have a low therapeutic index. Here, we synthesized and characterized a novel ω-conotoxin, Bu8 from Conus bullatus, which co
Externí odkaz:
https://doaj.org/article/a70fd78ef1424fb7afa9c9006cddbd6a
Autor:
Shuo Wang, Peter Bartels, Cong Zhao, Arsalan Yousuf, Zhuguo Liu, Shuo Yu, Anuja R. Bony, Xiaoli Ma, Qin Dai, Ting Sun, Na Liu, Mengke Yang, Rilei Yu, Weihong Du, David J. Adams, Qiuyun Dai
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
A novel 4/8 subtype α-conotoxin, Vt1.27 (NCCMFHTCPIDYSRFNC-NH2), was identified from Conus vitulinus in the South China Sea by RACE methods. The peptide was synthesized and structurally characterized. Similar to other α-conotoxins that target neuro
Externí odkaz:
https://doaj.org/article/3b40fc49ed124c818c7fb0be3c511e37
Autor:
Yuanmei Wei, Min Zhang, Shuo Yu, Qiuyuan Huang, Rongfang Chen, Shujing Xu, Yue Huang, Yunzhou Yu, Ming Liao, Qiuyun Dai
Publikováno v:
Marine Drugs, Vol 20, Iss 12, p 750 (2022)
α-conotoxin AuIB is the only one of the 4/6 type α-conotoxins (α-CTxs) that inhibits the γ-aminobutyric acid receptor B (GABABR)-coupled N-type calcium channel (CaV2.2). To improve its inhibitory activity, a series of variants were synthesized an
Externí odkaz:
https://doaj.org/article/8ad90b33b8824ed3b997b98dd2ea4d1b
Autor:
Xiaoli Ma, Qiuyuan Huang, Shuo Yu, Shujing Xu, Yue Huang, Zhiming Zhao, Xinrong Xiao, Qiuyun Dai
Publikováno v:
Marine Drugs, Vol 19, Iss 12, p 705 (2021)
α-Conotoxins GI and MI belong to the 3/5 subfamily of α-conotoxins and potently inhibit muscular nicotinic acetylcholine receptors (nAChRs). To date, no 3/4- or 3/6-subfamily α-conotoxins have been reported to inhibit muscular nAChRs. In the prese
Externí odkaz:
https://doaj.org/article/dbd26027242742bf8c2a5c0c17a7893a
Autor:
Zhuguo Liu, Zheng Yu, Shuo Yu, Cui Zhu, Mingxin Dong, Wenxiang Mao, Jie Hu, Mary Prorok, Ruibin Su, Qiuyun Dai
Publikováno v:
Marine Drugs, Vol 19, Iss 1, p 44 (2021)
N-methyl-D-aspartate receptor (NMDAR) antagonists have been found to be effective to inhibit morphine dependence. However, the discovery of the selective antagonist for NMDAR GluN2B with low side-effects still remains challenging. In the present stud
Externí odkaz:
https://doaj.org/article/72582b77df38454ebfe1ebd2f86eed32
Publikováno v:
Marine Drugs, Vol 13, Iss 6, Pp 3259-3275 (2015)
In the present study, we synthesized and, structurally and functionally characterized a novel α4/7-conotoxin Mr1.7 (PECCTHPACHVSHPELC-NH2), which was previously identified by cDNA libraries from Conus marmoreus in our lab. The NMR solution structure
Externí odkaz:
https://doaj.org/article/a149808813ce4a259c535aff6ab86cf8
Autor:
Yunxiao Zhang, Qiuyun Dai, Jinqin Chen, Shuo Yu, Rongfang Chen, Jia Liu, Ling Jiang, Xinhong Liu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2685-2693 (2021)
ω-Conotoxins inhibit N-type voltage-gated calcium (CaV2.2) channels and exhibit efficacy in attenuating neuropathic pain but have a low therapeutic index. Here, we synthesized and characterized a novel ω-conotoxin, Bu8 from Conus bullatus, which co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::332b2f5fcd91928f56144a24be3ffe16
https://doi.org/10.1016/j.apsb.2021.03.001
https://doi.org/10.1016/j.apsb.2021.03.001
Autor:
Qiuyuan Huang, Xin Chu, Haoran Zhang, Shuo Yu, Longxiao Zhang, Xuerong Zhang, Rilei Yu, Chenyun Guo, Qiuyun Dai
Publikováno v:
ACS chemical biology. 17(9)
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels widely distributed in the central peripheral nervous system and muscles which participate in rapid synaptic transmission. The α9α10 nAChR is an acetylcholine recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa00aee37a75f52dd277e65b6b4b0e2
https://pubmed.ncbi.nlm.nih.gov/36048451
https://pubmed.ncbi.nlm.nih.gov/36048451
Autor:
Longxiao Zhang, Chenyun Guo, Qiuyun Dai, David J. Adams, Liang Li, Biling Huang, Zhuguo Liu, Huying Ning, Han-Shen Tae, Shuo Yu
Publikováno v:
Journal of Neurochemistry. 159:90-100
α-Conotoxins are small disulfide-rich peptides found in the venom of marine cone snails and are potent antagonists of nicotinic acetylcholine receptors (nAChRs). They are valuable pharmacological tools and have potential therapeutic applications for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c558d61880f2b00ecf5adefca60a24d6
https://doi.org/10.1111/jnc.15434
https://doi.org/10.1111/jnc.15434
Autor:
Shuo Yu, Yumeng Li, Jinqin Chen, Yue Zhang, Xinling Tao, Qiuyun Dai, Yutian Wang, Shupeng Li, Mingxin Dong
Publikováno v:
Marine Drugs, Vol 17, Iss 5, p 286 (2019)
As the first in a new class of non-opioid drugs, ω-Conotoxin MVIIA was approved for the management of severe chronic pains in patients who are unresponsive to opioid therapy. Unfortunately, clinical application of MVIIA is severely limited due to it
Externí odkaz:
https://doaj.org/article/80e3f1a8ca76481fa9b16cbc9207dbac