Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Qiutang Li"'
Autor:
Subhash Gaddipati, Qingxian Lu, Ramesh Babu Kasetti, M Clarke Miller, Qingjun Lu, John O Trent, Henry J Kaplan, Qiutang Li
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121185 (2015)
The inhibition of NF-κB by genetic deletion or pharmacological inhibition of IKK2 significantly reduces laser-induced choroid neovascularization (CNV). To achieve a sustained and controlled intraocular release of a selective and potent IKK2 inhibito
Externí odkaz:
https://doaj.org/article/94cf95471a67464e961373062e37bb4f
Autor:
Huayi Lu, Qingxian Lu, Subhash Gaddipati, Ramesh Babu Kasetti, Wei Wang, Manolis Pasparakis, Henry J Kaplan, Qiutang Li
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87530 (2014)
Choroidal neovascularization (CNV) is aberrant angiogenesis associated with exudative age-related macular degeneration (AMD), a leading cause of blindness in the elderly. Inflammation has been suggested as a risk factor for AMD. The IKK2/NF-κB pathw
Externí odkaz:
https://doaj.org/article/8703e082299c4bbdb39776cf3db23f03
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115140 (2014)
Tyro3, Axl and Mertk (TAM) receptor tyrosine kinases play multiple functional roles by either providing intrinsic trophic support for cell growth or regulating the expression of target genes that are important in the homeostatic regulation of immune
Externí odkaz:
https://doaj.org/article/e262af105b574bf0b801a343d289c3e2
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e64812 (2013)
The Tyro3, Axl and Mertk (TAM) triply knockout (TKO) mice exhibit systemic autoimmune diseases, with characteristics of increased proinflammatory cytokine production, autoantibody deposition and autoreactive lymphocyte infiltration into a variety of
Externí odkaz:
https://doaj.org/article/5a6bb7b633ee4d2f93f731dbabc5d73d
Autor:
Henry J. Kaplan, Qiutang Li, Patrick A. Scott, Douglas C. Dean, Eric V. Vukmanic, Qingxian Lu
Publikováno v:
FASEB J
Nuclear YAP1 plays a critical role in regulation of stem cell proliferation, tissue regeneration, and organ size in many types of epithelia. Due to rapid turnover of most epithelial cell types, the cytoplasmic function of YAP1 in epithelial cells has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672559c7724e5ea358771564ce0db792
https://doi.org/10.1096/fj.201903234r
https://doi.org/10.1096/fj.201903234r
Autor:
Qingxian Lu, Yingnan Zhang, Naresh Kumar Cvm, Qiutang Li, Douglas Borchman, Ramesh B. Kasetti, Subhash Gaddipati
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Yap1 encodes an evolutionarily conserved transcriptional coactivator and functions as a down-stream effector of the Hippo signaling pathway that controls tissue size and cell growth. Yap1 contributes to lens epithelial development. However, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245ecd320dc757b46f4685802afb5290
http://europepmc.org/articles/PMC7585397
http://europepmc.org/articles/PMC7585397
Autor:
Mingliang Zhang, Xiaorong Li, Qiutang Li, Lei Zhou, Mingming Ma, Xiaomin Zhang, Hui Shao, Feifei Ma, Bing Li, Fuhua Yang
Publikováno v:
Experimental eye research. 191
Retinal detachment (RD) induces ischemia and oxygen deficiency in the retina and results in multiple pathological events; photoreceptor cell degeneration and death is the eventual cause of vision decline. In this study, we investigated the therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04239ea8a8b52c8ad1bdfa5fe19d412c
https://pubmed.ncbi.nlm.nih.gov/31866431
https://pubmed.ncbi.nlm.nih.gov/31866431
Autor:
Yan Zhang, Hong Zhang, Wenbo Li, Xiaorong Li, Lijie Dong, Fang Tian, Yan Shao, Hong Nian, Xiaomin Zhang, Yue Yi, Fei Wang, Qiutang Li
Publikováno v:
Cell and Tissue Research. 360:233-243
Pathological retinal neovascularization, including retinopathy of prematurity and age-related macular degeneration, is the most common cause of blindness worldwide. Insulin-like growth factor-1 (IGF-1) has a direct mitogenic effect on endothelial cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d2b7474105f3d13f01a31c5f40318c
https://doi.org/10.1007/s00441-014-2104-5
https://doi.org/10.1007/s00441-014-2104-5
Publikováno v:
Metabolic Brain Disease. 30:943-950
Phagocytic clearance of the spent photoreceptor outer segments (OS) by RPE cells is regulated by circadian rhythm cycle and is essential for photoreceptor integrity and function. Mertk regulates RPE phagocytosis and a deficiency in Mertk causes photo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85b7f8d6221931df1d08096a6269147
https://doi.org/10.1007/s11011-015-9653-5
https://doi.org/10.1007/s11011-015-9653-5
Autor:
Jixiang Ding, Qingjun Lu, Qiutang Li, Shifu Tian, Rui Ji, Yan Zheng, Helen J. Lu, Xiaomin Wang, Qingxian Lu
Publikováno v:
The Journal of Immunology. 191:6165-6177
TAM tyrosine kinases play multiple functional roles, including regulation of the target genes important in homeostatic regulation of cytokine receptors or TLR-mediated signal transduction pathways. In this study, we show that TAM receptors affect adu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4d5a09c948b8daa5c5b3fe5baee85f
https://doi.org/10.4049/jimmunol.1302229
https://doi.org/10.4049/jimmunol.1302229