Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Qiurong Ding"'
Autor:
Jiayu Jin, Yunquan He, Jieyu Guo, Qi Pan, Xiangxiang Wei, Chen Xu, Zhiyuan Qi, Qinhan Li, Siyu Ma, Jiayi Lin, Nan Jiang, Jinghua Ma, Xinhong Wang, Lindi Jiang, Qiurong Ding, Elena Osto, Xiuling Zhi, Dan Meng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Hepatic insulin resistance is central to the metabolic syndrome. Here we investigate the role of BTB and CNC homology 1 (BACH1) in hepatic insulin signaling. BACH1 is elevated in the hepatocytes of individuals with obesity and patients with
Externí odkaz:
https://doaj.org/article/0808983d7e5640c3b2950fbb7a889718
Publikováno v:
Cell Regeneration, Vol 12, Iss 1, Pp 1-13 (2023)
Abstract Preclinical models that can accurately predict the toxicity and efficacy of candidate drugs to human liver tissue are in urgent need. Human liver organoid (HLO) derived from human pluripotent stem cells offers a possible solution. Herein, we
Externí odkaz:
https://doaj.org/article/e40e5aca2eeb4d9ab8544b0770ee70e0
Autor:
Yanhao Chen, Lanlan Chen, Xiaoshan Wu, Yongxu Zhao, Yuchen Wang, Dacheng Jiang, Xiaojian Liu, Tingting Zhou, Shuang Li, Yuda Wei, Yan Liu, Cheng Hu, Ben Zhou, Jun Qin, Hao Ying, Qiurong Ding
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Early lipid accumulation is thought to contribute to liver regeneration through unclear functional mechanisms. Here the authors identify an epigenetic regulator, MIER1, that bridges the acute lipid accumulation and cell cycle gene transcription durin
Externí odkaz:
https://doaj.org/article/ddadd979f32c40c1a99e16a41b063b55
Autor:
Jun Han, Yuchen Wang, Yan Qiu, Diya Sun, Yan Liu, Zhigang Li, Ben Zhou, Haibing Zhang, Yichuan Xiao, Guohao Wu, Qiurong Ding
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-22 (2022)
Abstract Adipose tissue loss seen with cancer-associated cachexia (CAC) may functionally drive cachexia development. Using single-cell transcriptomics, we unveil a large-scale comprehensive cellular census of the stromal vascular fraction of white ad
Externí odkaz:
https://doaj.org/article/1f58f0d250ba4d58bb54be8b9a35df26
Autor:
Wei Su, Hao Hu, Qiurong Ding, Min Wang, Yan Zhu, Zhaochao Zhang, Zihan Geng, Shengli Lin, Pinghong Zhou
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background Esophageal Squamous Cell Carcinoma (ESCC) was characterized as a regional-prevalent and aggressive tumor with high morbidity and mortality. NIMA-related kinase 2 (NEK2) is an interesting oncogene, the alteration of which leads to
Externí odkaz:
https://doaj.org/article/c5d39095891842c6b86cdc458857f42c
Autor:
Yanhao Chen, Qiurong Ding
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101062- (2022)
Summary: We provide a protocol for gene editing in mouse hepatocytes in vivo using the CRISPR-Cas9 technology via AAV delivery. This protocol describes the construction of AAV plasmids, AAV packaging, injection, and the detection of in vivo knockout
Externí odkaz:
https://doaj.org/article/b0801e1fe8014e7cb74b2ae906053a8c
Publikováno v:
Cell Reports, Vol 29, Iss 3, Pp 781-784 (2019)
Summary: This Matters Arising Response paper addresses the Hoch et al. (2019) Matters Arising paper published concurrently in this issue of Cell Reports. The genetic study in humans revealed a strong association of DNA variants in the SLC16A11 coding
Externí odkaz:
https://doaj.org/article/d9ec0a064cb24462a470c40c21968a29
Autor:
Xixi Zhang, Haiwei Zhang, Chengxian Xu, Xiaoming Li, Ming Li, Xiaoxia Wu, Wenjuan Pu, Bin Zhou, Haikun Wang, Dali Li, Qiurong Ding, Hao Ying, Hui Wang, Haibing Zhang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
RIPK1 integrates signals that drive both NF-κB activation and cell death pathways. Here Zhang et al. generate RIPK1 knock-in mice lacking a major ubiquitination site and demonstrate that this modification is important to suppress cell death during e
Externí odkaz:
https://doaj.org/article/7a20ff8bd8654fe78c8cee847d1dc433
Autor:
Yan Qiu, Qiurong Ding
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100307- (2021)
Summary: We present a detailed protocol for gene editing in adipocytes using the CRISPR-Cas technology. This protocol describes sgRNA design, preparation of lentiCRISPR-sgRNA vectors, functional validation of sgRNAs, preparation of lentiviruses, and
Externí odkaz:
https://doaj.org/article/9803d10fba1048bd90f358b40915af4f
Autor:
Yan Qiu, Yingmin Sun, Danqing Xu, Yuanyuan Yang, Xiaojian Liu, Yuda Wei, Yanhao Chen, Zhuanghui Feng, Shuang Li, Md. Reyad-ul Ferdous, Yongxu Zhao, Hongxi Xu, Yuanzhi Lao, Qiurong Ding
Publikováno v:
EBioMedicine, Vol 37, Iss , Pp 344-355 (2018)
Background: The pharmacological activation of thermogenesis in brown adipose tissue has long been considered promising strategies to treat obesity. However, identification of safe and effective agents remains a challenge. In this study, we addressed
Externí odkaz:
https://doaj.org/article/47c80c7323fe4b7a985191bbb7c4dd10