TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer

Autor: Yanting Lin, Rui Gao, Dongquan Jing, Yiming Liu, Huijuan Da, Lutz Birnbaumer, Yong Yang, Xinghua Gao, Zhenhua Gao, Qiuhua Cao

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

During the past half-century, although numerous interventions for obesity have arisen, the condition’s prevalence has relentlessly escalated annually. Obesity represents a substantial public health challenge, especially due to its robust correlatio

Externí odkaz: https://doaj.org/article/1a0ef4cffe9b4113afa5f2271f4e4f0d

ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury

Autor: Yue Wang, Menghan Zhang, Ran Bi, Yali Su, Fei Quan, Yanting Lin, Chongxiu Yue, Xinmeng Cui, Qixiang Zhao, Siliang Liu, Yong Yang, Dayong Zhang, Qiuhua Cao, Xinghua Gao

Publikováno v: Redox Biology, Vol 51, Iss , Pp 102262- (2022)

The term ferroptosis coined in 2012 causes acute kidney injury (AKI). However, its pathway mechanism in AKI is poorly understood. In this study, we conducted an RNA-sequence analysis of kidneys in AKI and normal mice to explore the pathway mechanism

Externí odkaz: https://doaj.org/article/c3bfa1593ae7488c8e1e2c4d64f17c28

TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis

Autor: Yanting, Lin, Xinmeng, Cui, Qiuhua, Cao, Ran, Bi, Yiming, Liu, Dongquan, Jing, Chongxiu, Yue, Qixiang, Zhao, Yue, Wang, Siliang, Liu, Yali, Su, Karina, Formoso, Sebastian, Susperreguy, Lutz, Birnbaumer, Marc, Freichel, Yong, Yang, Linjun, You, Xinghua, Gao

Publikováno v: International Immunopharmacology. 115:109655

The transient receptor potential canonical (TRPC) channels, encoded in seven non-allelic genes, are important contributors to calcium fluxes, are strongly associated with various diseases. Here we explored the consequences of ablating all seven TRPCs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3b3ad58ace1633083ce5c3e9d68b32
https://doi.org/10.1016/j.intimp.2022.109655

Quercetin alleviates acute kidney injury by inhibiting ferroptosis

Autor: Chongxiu Yue, Xianjing Li, Lutz Birnbaumer, Yanting Lin, Hongbao Yang, Xinghua Gao, Yong Yang, Yue Wang, Ran Bi, Qiuhua Cao, Xinmeng Cui, Fei Quan

Publikováno v: Journal of Advanced Research Vol. 28, 2021
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA
Journal of Advanced Research, Vol 28, Iss, Pp 231-243 (2021)
Journal of Advanced Research

Graphical abstract A proposed model illustrating the therapeutic effect of QCT on AKI. QCT inhibits the expression of ATF3. While ATF3 blocks the system Xc-, and then suppresses GPX4, inducing ferroptosis. In another side, ferroptotic cells secrete c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d860d7d90ee30c534e13a65f5df36cb8
https://repositorio.uca.edu.ar/handle/123456789/11638

IL-6 deficiency promotes colitis by recruiting Ly6Chi monocytes into inflamed colon tissues in a CCL2-CCR2-dependent manner

Autor: Xinghua Gao, Chongxiu Yue, Yong Yang, Xianjing Li, Fei Quan, Yue Wang, Xinying Tang, Qiuhua Cao, Ran Bi, Yanting Lin, Chen Wang, Xinmeng Cui

Publikováno v: European Journal of Pharmacology. 904:174165

Interleukin 6 (IL-6) is a pleiotropic cytokine that is elevated in inflammatory bowel disease. However, the role of IL-6 deficiency in colitis is not well-defined. Some IL-6 and IL-6 receptor antagonists are associated with severe gastrointestinal im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0bcf9479aa1bc9bd4cda679c768271e
https://doi.org/10.1016/j.ejphar.2021.174165