HLA-DPB1 genotype variants predict DP molecule cell surface expression and DP donor specific antibody binding capacity

Autor: Yuxin Yin, Nwe Nwe Soe, Nicole M. Valenzuela, Elaine F. Reed, Qiuheng Zhang

Publikováno v: Frontiers in Immunology, Vol 14 (2024)

The contribution of alloresponses to mismatched HLA-DP in solid organ transplantation and hematopoietic stem cell transplantation (HCT) has been well documented. Exploring the regulatory mechanisms of DPB1 alleles has become an important question to

Externí odkaz: https://doaj.org/article/c98bb351c94c43d8b210bd828e983fdc

Application of High-Throughput Next-Generation Sequencing for HLA Typing on Buccal Extracted DNA: Results from over 10,000 Donor Recruitment Samples.

Autor: Yuxin Yin, James H Lan, David Nguyen, Nicole Valenzuela, Ping Takemura, Yung-Tsi Bolon, Brianna Springer, Katsuyuki Saito, Ying Zheng, Tim Hague, Agnes Pasztor, Gyorgy Horvath, Krisztina Rigo, Elaine F Reed, Qiuheng Zhang

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0165810 (2016)

Unambiguous HLA typing is important in hematopoietic stem cell transplantation (HSCT), HLA disease association studies, and solid organ transplantation. However, current molecular typing methods only interrogate the antigen recognition site (ARS) of

Externí odkaz: https://doaj.org/article/93b13782bd134bffa4528fe1a03a5bcd

The allograft injury marker CXCL9 determines prognosis of anti-HLA antibodies after lung transplantation

Autor: Ian Britton, Michael Y. Shino, Qiuheng Zhang, S. Sam Weigt, Abbas Ardehali, Michelle J. Hickey, Barry R. Stripp, David M. Sayah, Gregory A. Fishbein, Paul W. Noble, Allison Ramsey, Joseph P. Lynch rd, Ning Li, Elaine F. Reed, John A. Belperio, Ariss Derhovanessian, Shahrzad M. Lari, Rajan Saggar, Olawale Amubieya

Publikováno v: American Journal of Transplantation. 22:565-573

Despite the common detection of non-donor specific anti-HLA antibodies (non-DSAs) after lung transplantation, their clinical significance remains unclear. In this retrospective single-center cohort study of 325 lung transplant recipients, we evaluate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e9ab072eb7913a807aaa5d67bc797c
https://doi.org/10.1111/ajt.16827

Safety and Efficacy of a Steroid Avoidance Immunosuppression Regimen in Renal Transplant Patients With De Novo or Preformed Donor-Specific Antibodies: A Single-Center Study

Autor: Jonathan S. Fisher, Sunil M. Kurian, Randolph Schaffer, Bethany Barrick, Jamie Case, Alice E. Toll, Elaine F. Reed, Christopher L. Marsh, Michael M. Quigley, James C. Rice, Ryan J. Schutt, Samantha R. Spierling Bagsic, Qiuheng Zhang

Publikováno v: Transplantation Proceedings. 53:950-961

Although interest in the role of donor-specific antibodies (DSAs) in kidney transplant rejection, graft survival, and histopathological outcomes is increasing, their impact on steroid avoidance or minimization in renal transplant populations is poorl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833be3e446ea9cb2fd4f2ae7837d38e1
https://doi.org/10.1016/j.transproceed.2020.10.021

Discovery of non-HLA antibodies associated with cardiac allograft rejection and development and validation of a non-HLA antigen multiplex panel: From bench to bedside

Autor: Adrian B. Van Bakel, Jon A. Kobashigawa, Ying Zheng, Michelle J. Hickey, Bryan Ray, David W. Gjertson, Gregory A. Fishbein, Reshma Biniwale, Hector L. Banchs, Howard J. Eisen, G. Torre, Randall C. Starling, Murray Kwon, A. Baas, Carrie Butler, Daniel Cruz, Ivan Balazs, Ali Nsair, Mario C. Deng, Ning Jiang, Ping Rao, Martin Cadeiras, Abbas Ardehali, Reza Ardehali, David DeNofrio, Qiuheng Zhang, Elaine F. Reed, Gregory A. Ewald, Abdallah G. Kfoury

Publikováno v: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol 20, iss 10

We analyzed humoral immune responses to nonhuman leukocyte antigen (HLA) after cardiac transplantation to identify antibodies associated with allograft rejection. Protein microarray identified 366 non-HLA antibodies (>1.5 fold, P1R) with an area unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee4fe631032da46f7f879bf4c0238dc
https://pubmed.ncbi.nlm.nih.gov/32372531