Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Qiufen He"'
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-12 (2021)
Abstract Accumulating evidence has revealed that mitochondria dynamics and function regulation is essential for the successful mesenchymal stem cell (MSC) differentiation. In the present study, the researchers reported for the first time that Mtu1 de
Externí odkaz:
https://doaj.org/article/d1a81253b47642e3b0c7704c7c1dc330
Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss
Autor:
Limei Cui, Jing Zheng, Qiong Zhao, Jia-Rong Chen, Hanqing Liu, Guanghua Peng, Yue Wu, Chao Chen, Qiufen He, Haosong Shi, Shankai Yin, Rick A. Friedman, Ye Chen, Min-Xin Guan
Publikováno v:
JCI Insight, Vol 5, Iss 23 (2020)
The pathophysiology underlying spiral ganglion cell defect–induced deafness remains elusive. Using the whole exome sequencing approach, in combination with functional assays and a mouse disease model, we identified the potentially novel deafness-ca
Externí odkaz:
https://doaj.org/article/d7b9609d77224c7ba5b56f7c0d1119f2
Autor:
Qiong Zhao, Luwen Zhang, Qiufen He, Hui Chang, Zhiqiang Wang, Hongcui Cao, Ying Zhou, Ruolang Pan, Ye Chen
Publikováno v:
J Zhejiang Univ Sci B
Accumulating evidence has confirmed the links between transfer RNA (tRNA) modifications and tumor progression. The present study is the first to explore the role of tRNA methyltransferase 5 (TRMT5), which catalyzes the m1G37 modification of mitochond
Publikováno v:
Human cell. 35(5)
Ovarian granulosa cell (OGC) is a critical somatic component of the ovary, which provides physical support and the microenvironment required for the developing oocyte. Human OGCs are easy to obtain and culture as a by-product of follicular aspiration
Autor:
Qinghai Zhang, Feilong Meng, Yun Xiao, Meng Wang, Zidong Jia, Fengguo Zhang, Qiufen He, Min-Xin Guan, Haibo Wang, Lei Xu
Publikováno v:
Nucleic Acids Research
In this report, we investigated the molecular mechanism underlying a deafness-associated m.7516delA mutation affecting the 5′ end processing sites of mitochondrial tRNAAsp and tRNASer(UCN). An in vitro processing experiment demonstrated that m.7516
Publikováno v:
The Journal of Biological Chemistry
Mammalian mitochondrial tRNA (mt-tRNA) plays a central role in the synthesis of the 13 subunits of the oxidative phosphorylation complex system (OXPHOS). However, many aspects of the context-dependent expression of mt-tRNAs in mammals remain unknown.
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 1, Pp 1-12 (2021)
Cell Death and Disease, Vol 12, Iss 1, Pp 1-12 (2021)
Accumulating evidence has revealed that mitochondria dynamics and function regulation is essential for the successful mesenchymal stem cell (MSC) differentiation. In the present study, the researchers reported for the first time that Mtu1 defects are
Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss
Autor:
Yue Wu, Jing Zheng, Qiufen He, Haosong Shi, Min-Xin Guan, Limei Cui, Jiarong Chen, Qiong Zhao, Guanghua Peng, Rick A. Friedman, S K Yin, Ye Chen, Hanqing Liu, Chao Chen
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 23 (2020)
JCI Insight, Vol 5, Iss 23 (2020)
The pathophysiology underlying spiral ganglion cell defect–induced deafness remains elusive. Using the whole exome sequencing approach, in combination with functional assays and a mouse disease model, we identified the potentially novel deafness-ca
Autor:
Ling Xue, Haiying Li, Min-Xin Guan, Bibin Wang, Mi Zhou, Feilong Meng, Meng Wang, Yaru Chen, Qiufen He
Publikováno v:
Journal of Biological Chemistry. 293:1425-1438
Defective nucleotide modifications of mitochondrial tRNAs have been associated with several human diseases, but their pathophysiology remains poorly understood. In this report, we investigated the pathogenic molecular mechanism underlying a hypertens
Autor:
Haiying Li, Pingping Jiang, Ling Xue, Zhi Lin, Meng Wang, Mi Zhou, Xiaofen Jin, Min-Xin Guan, Wenwen Shi, Yaru Chen, Qiufen He
Publikováno v:
Journal of Biological Chemistry. 292:13934-13946
Several mitochondrial tRNA mutations have been associated with hypertension, but their pathophysiology remains poorly understood. In this report, we identified a novel homoplasmic 3253T→C mutation in the mitochondrial tRNALeu(UUR) gene in a Han Chi