Výsledky vyhledávání - "Qiudong Zhuo"

Abstract 4263: A novel pegylated biparatopic antibody-drug conjugate (pb-adc) targeting cancers with low HER2+ expression

Autor: Shumin Liu, Shuqiang Yin, Weidong Lyu, Yang Lei, Qiudong Zhuo, Zibin Wu, Shuangyu Tan, Liling Zheng, Yu (Yvonne) Wen, David Wu

Publikováno v: Cancer Research. 82:4263-4263

ADCs have demonstrated much improved target selectivity and efficacy comparing to the nonspecific cytotoxic small molecule drug. The goal of ADC technology is to resolve the toxicity issue inherent in potent small molecule drugs. Yet, the main proble

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::779a43d818279ce5768645a6c1d9a4e0
https://doi.org/10.1158/1538-7445.am2022-4263

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Abstract 1868: A long acting bi-specific T cell engager differentially targeting CD47 positive malignant cells but not CD47 expressing healthy cells

Autor: Shuangyu Tan, Zibin Wu, David Wu, Liling Zheng, Lyu Weidong, Qiudong Zhuo, Shuqiang Yin, Yu (Yvonne) Wen, Lei Yang, Liu Shumin

Publikováno v: Cancer Research. 81:1868-1868

Currently both bispecific T cell engagers (BiTE) and innate immune checkpoint blockades (eg. Anti-CD47/SIRPα) have been under development. In this study, we developed a novel compound pegylated anti-CD3 x anti-CD47 which could act with dual mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a70cadfffa7e56cf70601611a2f193ec
https://doi.org/10.1158/1538-7445.am2021-1868

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