Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Qiu-hua Gu"'
Publikováno v:
BMC Nephrology, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background Thyroid dysfunction is common in patients with nephrotic syndrome, especially patients with primary membranous nephropathy (pMN). In view of both MN and thyroid dysfunction are associated with autoimmunity, the current study aimed
Externí odkaz:
https://doaj.org/article/33cd0581daad42ba99ed0c0052503057
Autor:
Jing Huang, Zhao Cui, Qiu-Hua Gu, Yi-Miao Zhang, Zhen Qu, Xin Wang, Fang Wang, Xu-Yang Cheng, Li-Qiang Meng, Gang Liu, Ming-Hui Zhao
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234934 (2020)
BackgroundStudies on adriamycin mice model suggest complement system is activated and together with IgM contributes to the glomerular injury of primary focal segmental glomerulosclerosis (FSGS). We recently reported primary FSGS patients with IgM and
Externí odkaz:
https://doaj.org/article/c1b1f561daae42e2b7a3513d1b7a8296
Autor:
Tai Jiao Jiang, A. Richard Kitching, Ming Hui Zhao, Joshua D. Ooi, Megan Huynh, Zhao Cui, Yue Shi, Xiao Yu Jia, Qiu Hua Gu, Jie Jian Luo
Publikováno v:
Journal of the American Society of Nephrology. 31:1282-1295
Background Antiglomerular basement membrane (anti-GBM) disease is associated with HLA-DRB1*1501 (the major predisposing genetic factor in the disease), with α3127-148 as a nephritogenic T and B cell epitope. Although the cause of disease remains unc
Autor:
Xiao-dan Zhang, Cai-xia Lin, Zhao Cui, Qiu-hua Gu, Bing-jia Yan, Lei Liu, Wen-chao Song, Yi Shi, Hanna Debiec, Pierre Ronco, Ming-hui Zhao
Publikováno v:
Kidney international.
The M-type phospholipase A2 receptor (PLA2R) is the major autoantigen of primary membranous nephropathy (MN). Despite many studies on B-cell epitopes recognized by antibodies, little is known about T-cell epitopes. Herein, we synthesized 123 linear p
Autor:
Qiu-Hua, Gu, Megan, Huynh, Yue, Shi, Xiao-Yu, Jia, Jie-Jian, Luo, Tai-Jiao, Jiang, Zhao, Cui, Joshua D, Ooi, A Richard, Kitching, Ming-Hui, Zhao
Publikováno v:
J Am Soc Nephrol
BACKGROUND: Antiglomerular basement membrane (anti-GBM) disease is associated with HLA-DRB1*1501 (the major predisposing genetic factor in the disease), with α3(127–148) as a nephritogenic T and B cell epitope. Although the cause of disease remain
Publikováno v:
Nephrology. 23:476-482
AIM Anti-glomerular basement membrane (GBM) disease is an autoimmune disorder with rapidly progressive glomerulonephritis and alveolar haemorrhage. Fever symptoms and prodromal infections have been reported in many cases, but still not been elucidate
Autor:
Xu-yang Cheng, Zhao Cui, Chong-Yan Yu, Qi-zhuang Jin, Fu-de Zhou, Qiu-hua Gu, Ming-Hui Zhao, Shui-yi Hu, Xiao-yu Jia
Publikováno v:
Nephrology. 23:345-350
Aim Cell-mediated autoimmunity, especially autoreactive T cells, is crucial in the initiation of anti-glomerular membrane (GBM) disease. Epitopes for T cells on Goodpasture autoantigen are not fully defined. This study investigated T cell epitopes in
Publikováno v:
Molecular Immunology. 88:1-9
Background Anti-GBM disease is caused by autoimmunity to Goodpasture antigen on α3(IV)NC1 and had strong associations with HLA-DRB1*1501. Previous studies identified α3 127-148 (P14: TDIPPCPHGWISLWKGFSFIMF) as a T cell epitope. The present study wa
Publikováno v:
Rheumatology. 56:iii81-iii84
Publikováno v:
J Am Soc Nephrol
Background In Goodpasture disease, the noncollagenous domain 1 of the α3 chain (α3NC1) of type IV collagen is the main target antigen of antibodies against glomerular basement membrane (GBM). We previously identified a nephritogenic epitope, P14 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810c83b3d768db84604caaf7da996d57
https://europepmc.org/articles/PMC6935000/
https://europepmc.org/articles/PMC6935000/