Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Qiu-Xiang Hu"'
Autor:
Roni Dhaher, Bjørnar Hassel, Fahmeed Hyder, Yun Zhou, Siu-Pok Yee, Shaun E. Gruenbaum, Qiu Xiang Hu, Niels C. Danbolt, Tore Eid, Maxime Parent
Publikováno v:
Neurochem Int
Glutamate-ammonia ligase (glutamine synthetase; Glul) is enriched in astrocytes and serves as the primary enzyme for ammonia detoxification and glutamate inactivation in the brain. Loss of astroglial Glul is reported in hippocampi of epileptic patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ca1f5ec089d7e1f172723336a6b284
https://doi.org/10.1016/j.neuint.2018.07.009
https://doi.org/10.1016/j.neuint.2018.07.009
Autor:
Lise Verbruggen, Ann Massie, Ruben Gudmundsrud, Niels C. Danbolt, Sigrid Ottestad-Hansen, Yun Zhou, Qiu-Xiang Hu, Gesa M Klatt
Proper glutamatergic neurotransmission requires a balance between glutamate release and removal. The removal is mainly catalyzed by the glutamate transporters EAAT1-3, while the glutamate-cystine exchanger (system xc− with specific subunit xCT) rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec3b4e11b2f5b2e02cdb6366bfdc044
http://hdl.handle.net/10852/80497
http://hdl.handle.net/10852/80497
Autor:
Hong-Yan Jiang, Tao Li, Deng-Feng Zhang, Rui Bi, Yiru Fang, Min Xu, Qiu-Xiang Hu, Yu Fan, Liwen Tan, Wen Zhang, Yong-Gang Yao, Chen Zhang
Publikováno v:
Neuropsychopharmacology. 43:2264-2276
Alzheimer’s disease (AD) is the most common cause of dementia. Mitochondrial dysfunction has been widely reported in AD due to its important role in cellular metabolism and energy production. Complex IV (cytochrome c oxidase, COX) of mitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d32ce5e2d2a3e1a8313dc59c9d9bf9
https://doi.org/10.1038/s41386-018-0144-3
https://doi.org/10.1038/s41386-018-0144-3
Autor:
Sigrid Ottestad-Hansen, Qiu Xiang Hu, Bjørnar Hassel, Yun Zhou, Niels C. Danbolt, Silvia Holmseth
Publikováno v:
Journal of Histochemistry & Cytochemistry. 66:189-202
Glutamate transport activities have been identified not only in the brain, but also in the liver, kidney, and intestine. Although glutamate transporter distributions in the central nervous system are fairly well known, there are still uncertainties w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c2bc1bcbdb39b3afeda9944b256dda
https://doi.org/10.1369/0022155417749828
https://doi.org/10.1369/0022155417749828
Autor:
Ann Massie, Virgine Veronique Follin-Arbelet, Yun Zhou, Sigrid Ottestad-Hansen, Hideyo Sato, Qiu Xiang Hu, Niels C. Danbolt, Eduard Bentea
The cystine-glutamate exchanger (xCT) promotes glutathione synthesis by catalyzing cystine uptake and glutamate release. The released glutamate may modulate normal neural signaling and contribute to excitotoxicity in pathological situations. Uncertai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955e3945db56a918d95376b04e60f3a2
http://hdl.handle.net/10852/73005
http://hdl.handle.net/10852/73005
Autor:
Wanjun Guo, Tao Li, Wei Deng, Rui Bi, Qun Xiang, Hui-Zhen Wang, Yong-Gang Yao, Wen Zhang, Qiu-Xiang Hu, Xiaohong Ma, Deng-Feng Zhang, Peiyan Ni, Yiru Fang, Liansheng Zhao, Chen Zhang, Mingli Li
Publikováno v:
Molecular Neurobiology. 53:379-390
In recent years, genome-wide association studies (GWASs) have identified many novel susceptible genes/loci for Alzheimer's disease (AD). However, most of these studies were conducted in European and populations of European origin, and limited studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b10962a692769df3849b88544cabce
https://doi.org/10.1007/s12035-014-9015-z
https://doi.org/10.1007/s12035-014-9015-z
Publikováno v:
Molecular neurobiology. 54(3)
While many patients with hereditary optic neuropathies are caused by mitochondrial DNA (mtDNA) mutations of Leber's hereditary optic neuropathy (LHON), a significant proportion of them does not have mtDNA mutation and is caused by mutations in genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f6f3b4ebbfd191a21abb571d961698
https://pubmed.ncbi.nlm.nih.gov/26867657
https://pubmed.ncbi.nlm.nih.gov/26867657
Autor:
Wen Zhang, Yong-Tang Zheng, Hao Guo, Feng-Liang Liu, Rui Bi, Qiu-Xiang Hu, Yong-Gang Yao, A-Mei Zhang, Ian Logan, Bi-Qing Yang
Publikováno v:
Molecular neurobiology. 53(6)
Drug addiction is one of the most serious social problems in the world today and addicts are always at a high risk of acquiring HIV infection. Mitochondrial impairment has been reported in both drug addicts and in HIV patients undergoing treatment. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c23eaec014eda61f2aa13941c98f54e
https://pubmed.ncbi.nlm.nih.gov/26162319
https://pubmed.ncbi.nlm.nih.gov/26162319
Autor:
Wei Pang, Yong-Gang Yao, Longbao Lv, Yu Fan, Ling Xu, Yong-Tang Zheng, Shuang Wang, Qiu-Xiang Hu
Publikováno v:
Gene. 571(2)
As a non-human primate, the pig-tailed macaque has received wide attention because it can be infected by HIV-1. In this study, we determined the complete mtDNA sequence of the northern pig-tailed macaque (Macaca leonina). Unexpectedly, during the amp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557c1495903d07c0260fc6e47fa0247f
https://pubmed.ncbi.nlm.nih.gov/26151895
https://pubmed.ncbi.nlm.nih.gov/26151895
Autor:
Tao Li, Rui Bi, Jianliang Ni, Dong Wang, Guo-Dong Li, Y. Wang, Weihong Lu, Jiangtao Zhang, Liansheng Zhao, Qiu-Xiang Hu, Yong-Gang Yao, Chen Zhang, Jia-Qi Feng
Publikováno v:
Neurobiology of aging. 35(2)
The leucine-rich repeat kinase-2 (LRRK2) gene has been regarded as 1 of the most common genetic causes of Parkinson's disease (PD). We hypothesized that LRRK2-susceptible allele(s) for PD might pose a risk for Alzheimer's disease (AD). In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9058b833907c83fb65aa46c40fc4c0fe
https://pubmed.ncbi.nlm.nih.gov/24080176
https://pubmed.ncbi.nlm.nih.gov/24080176