Výsledky vyhledávání - "Qiu‐Zhi Zhou"

Akademický článek

Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss

Publikováno v: Military Medical Research, Vol 11, Iss 1, Pp 1-24 (2024)

Abstract Background Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease (AD), which is closely related to tau pathology and hippocampal impairment. Due to the heterogeneity of brain neurons, the specific roles of diffe

Externí odkaz: https://doaj.org/article/df673dbc95c04f9d9dc2c62b7ff993ba

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Akademický článek

Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling

Autor: Meng-Zhu Li, En-Jie Liu, Qiu-Zhi Zhou, Shi-Hong Li, Shi-Jie Liu, Hai-Tao Yu, Qi-Hang Pan, Fei Sun, Ting He, Wei-Jin Wang, Dan Ke, Yu-Qi Feng, Jun Li, Jian-Zhi Wang

Publikováno v: Military Medical Research, Vol 9, Iss 1, Pp 1-16 (2022)

Abstract Background Autophagy dysfunction plays a crucial role in tau accumulation and neurodegeneration in Alzheimer’s disease (AD). This study aimed to investigate whether and how the accumulating tau may in turn affect autophagy. Methods The pri

Externí odkaz: https://doaj.org/article/c3d580c51c4a4c6a9ce76531a6abec8a

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Akademický článek

P301S‐hTau acetylates KEAP1 to trigger synaptic toxicity via inhibiting NRF2/ARE pathway: A novel mechanism underlying hTau‐induced synaptic toxicities

Autor: Jia‐Zhao Xie, Yao Zhang, Shi‐Hong Li, Hui Wei, Hui‐Ling Yu, Qiu‐Zhi Zhou, Lin‐Yu Wei, Dan Ke, Qun Wang, Ying Yang, Jian‐Zhi Wang

Publikováno v: Clinical and Translational Medicine, Vol 12, Iss 8, Pp n/a-n/a (2022)

Abstract Background Human Tau (hTau) accumulation and synapse loss are two pathological hallmarks of tauopathies. However, whether and how hTau exerts toxic effects on synapses remain elusive. Methods Mutated hTau (P301S) was overexpressed in the N2a

Externí odkaz: https://doaj.org/article/637026b5410d440c99515a2c36a9eb46

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Akademický článek

Biomarkers for Early Diagnostic of Mild Cognitive Impairment in Type-2 Diabetes Patients: A Multicentre, Retrospective, Nested Case–Control Study

Publikováno v: EBioMedicine, Vol 5, Iss C, Pp 105-113 (2016)

Background: Both type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) are common age-associated disorders and T2DM patients show an increased risk to suffer from AD, however, there is currently no marker to identify who in T2DM populations wi

Externí odkaz: https://doaj.org/article/07cfe083271e425fa8949f178032c651

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Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling

Autor: Meng-Zhu Li, En-Jie Liu, Qiu-Zhi Zhou, Shi-Hong Li, Shi-Jie Liu, Hai-Tao Yu, Qi-Hang Pan, Fei Sun, Ting He, Wei-Jin Wang, Dan Ke, Yu-Qi Feng, Jun Li, Jian-Zhi Wang

Publikováno v: Military Medical Research. 9(1)

Background Autophagy dysfunction plays a crucial role in tau accumulation and neurodegeneration in Alzheimer’s disease (AD). This study aimed to investigate whether and how the accumulating tau may in turn affect autophagy. Methods The primary hipp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fbc32b52e1a262bd59c64c8589cf88d
https://pubmed.ncbi.nlm.nih.gov/35799293

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