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Akademický článek

Revealing the spacing effect of neighboring side‐chains in modulating molecular aggregation and orientation of M‐series acceptors

Autor: Yunlong Ma, Shaoxin Luan, Dongdong Cai, Shu‐Quan Zhang, Jin‐Yun Wang, Qisheng Tu, Yuhang Zhu, Qingdong Zheng

Publikováno v: Aggregate, Vol 4, Iss 4, Pp n/a-n/a (2023)

Abstract Controlling the aggregation of small‐molecule acceptors (SMAs) is essential to obtain an optimal morphology and to improve the photovoltaic performance of polymer solar cells (PSCs). However, reducing intermolecular aggregation of SMAs is

Externí odkaz: https://doaj.org/article/b876972cf3354967919e56ef871f85ce

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Akademický článek

AdipoRon accelerates bone repair of calvarial defect in diet-induced obesity mice

Autor: Xingwen Wu, Danting Zhu, Le Shi, Qisheng Tu, Youcheng Yu, Jake Chen

Publikováno v: Heliyon, Vol 9, Iss 3, Pp e13975- (2023)

Objectives: To investigate the role of AdipoRon in bone wound healing of calvaria critical-sized defects (CSD) in diet-induced obesity (DIO) mice. Materials and methods: After establishing the calvaria CSD in normal-chow (NC), DIO and Adiponectin kno

Externí odkaz: https://doaj.org/article/8237bb34a8a24c60813e15649a84a879

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Akademický článek

Construction of ceRNA and m6A-related lncRNA networks associated with anti-inflammation of AdipoAI

Autor: Hongwen Yu, Hongle Wu, Qiuyan Xie, Zining Liu, Zehao Chen, Qisheng Tu, Jake Chen, Fuchun Fang, Wei Qiu

Publikováno v: Frontiers in Immunology, Vol 13 (2023)

BackgroundAdiponectin (APN) is an endogenous adipokine secreted from adipocytes that exerts anti-inflammatory properties. AdipoAI is an orally active adiponectin receptor agonist identified by our group that can emulate APN's anti-inflammatory proper

Externí odkaz: https://doaj.org/article/2c5062fdc66746ceb4a0ce78ddb54fa6

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Akademický článek

The Periodontal Pathogen Fusobacterium nucleatum Exacerbates Alzheimer’s Pathogenesis via Specific Pathways

Autor: Hongle Wu, Wei Qiu, Xiaofang Zhu, Xiangfen Li, Zhongcong Xie, Isabel Carreras, Alpaslan Dedeoglu, Thomas Van Dyke, Yiping W. Han, Nadeem Karimbux, Qisheng Tu, Lei Cheng, Jake Chen

Publikováno v: Frontiers in Aging Neuroscience, Vol 14 (2022)

Alzheimer’s Disease (AD) is the most common form of dementia in older adults and has a devastating impact on the patient’s quality of life, which creates a significant socio-economic burden for the affected individuals and their families. In rece

Externí odkaz: https://doaj.org/article/ad9c8b2201734b5b976017c5f363204a

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Akademický článek

Identification and Characterization of a Novel Long Noncoding RNA that Regulates Osteogenesis in Diet-Induced Obesity Mice

Autor: Zhekai Hu, Wei Qiu, Yuedi Yu, Xingwen Wu, Fuchun Fang, Xiaofang Zhu, Xiaoyang Xu, Qisheng Tu, Thomas E. Van Dyke, Elise F. Morgan, Jake Chen

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

As a precursor to type 2 diabetes mellitus (T2D), obesity adversely alters bone cell functions, causing decreased bone quality. Currently, the mechanisms leading to alterations in bone quality in obesity and subsequently T2D are largely unclear. Emer

Externí odkaz: https://doaj.org/article/b20fd3fda01348ec8447257a201829d6

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Akademický článek

Roles and Mechanisms of Irisin in Attenuating Pathological Features of Osteoarthritis

Autor: Xiangfen Li, Xiaofang Zhu, Hongle Wu, Thomas E. Van Dyke, Xiaoyang Xu, Elise F. Morgan, Wenyu Fu, Chuanju Liu, Qisheng Tu, Dingming Huang, Jake Chen

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

To investigate the effects and mechanisms of irisin, a newly discovered myokine, in cartilage development, osteoarthritis (OA) pathophysiology and its therapeutic potential for treating OA we applied the following five strategical analyses using (1)

Externí odkaz: https://doaj.org/article/f3df94293e9c44ffbc8bac428abd1658

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