Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Qiong Yao Tang"'
Autor:
Jing Liu, Xiao Liu, Wen-Yu Zhou, Jun Gan, Jie Wang, Qi Zhang, Jun-Liang Li, Zhong-Shan Shen, Yue-Ying Zhang, Qiong-Yao Tang, Zhe Zhang
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: The histaminergic neurons in the hypothalamic tuberomammillary nucleus (TMN) have been suggested to play a vital role in maintaining a rising state. But the neuronal types of the TMN are in debate and the role of GABAergic neurons remains
Externí odkaz:
https://doaj.org/article/449580f5d5544b2296ecc2bca0f926e6
Autor:
Ye Liu, Fang-Fang Zhang, Ying Song, Ran Wang, Qi Zhang, Zhong-Shan Shen, Fei-Fei Zhang, Dan-Ya Zhong, Xiao-Hui Wang, Qing Guo, Qiong-Yao Tang, Zhe Zhang
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
The role of the Slack (also known as Slo2.2, KNa1.1, or KCNT1) channel in pain-sensing is still in debate on which kind of pain it regulates. In the present study, we found that the Slack–/– mice exhibited decreased mechanical pain threshold but
Externí odkaz:
https://doaj.org/article/5bef003528e84550a9ac7b16a4f2adb5
Autor:
Jie Xu, Yan-Tian Lv, Xiao-Yun Zhao, Jing-Jing Wang, Zhong-Shan Shen, Jian Li, Fei-Fei Zhang, Jing Liu, Xiao-Hui Wang, Yun Xu, Qi Geng, Yi-Tong Ding, Jing-Jing Xu, Meng-Jiao Tan, Zhi-Xiao Li, Ran Wang, Jian Chen, Wen Sun, Meng Cui, Diomedes E. Logothetis, Jun-li Cao, Qiong-Yao Tang, Zhe Zhang
Publikováno v:
The Journal of Neuroscience. 43:2665-2681
The Slack channel (KCNT1, Slo2.2) is a sodium-activated and chloride-activated potassium channel that regulates heart rate and maintains the normal excitability of the nervous system. Despite intense interest in the sodium gating mechanism, a compreh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd8ac3af8ad1ec4660ef97e00e9fe02a
https://doi.org/10.1523/jneurosci.1365-22.2023
https://doi.org/10.1523/jneurosci.1365-22.2023
Autor:
Jia-Tian Yu, Ye Liu, Ping Dong, Run-En Cheng, Shao-Xi Ke, Kai-Qin Chen, Jing-Jing Wang, Zhong-Shan Shen, Qiong-Yao Tang, Zhe Zhang
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210670 (2019)
Oxidative stress has been considered as one of pathogenesis of brain damage led by epilepsy. Reducing oxidative stress can ameliorate brain damage during seizures. However, expression levels of important antioxidative enzymes such as thioredoxin-1 (T
Externí odkaz:
https://doaj.org/article/8cb8cca45a4e4347bcc8b5d902c5b06e
Autor:
Qiong-Yao Tang, Fei-Fei Zhang, Jie Xu, Ran Wang, Jian Chen, Diomedes E. Logothetis, Zhe Zhang
Publikováno v:
Cell Reports, Vol 14, Iss 1, Pp 129-139 (2016)
Twelve sodium-activated potassium channel (KCNT1, Slack) genetic mutants have been identified from severe early-onset epilepsy patients. The changes in biophysical properties of these mutants and the underlying mechanisms causing disease remain elusi
Externí odkaz:
https://doaj.org/article/78cba9e9e06f47f2bfdb4eb819184791
Autor:
Ying-Ying Zhang, Xue Han, Ye Liu, Jian Chen, Lei Hua, Qian Ma, Yang-Yu-Xin Huang, Qiong-Yao Tang, Zhe Zhang
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191749 (2018)
LRRC55 (leucine-rich repeat-containing protein 55) protein is an auxiliary γ subunit of BK (Big conductance potassium channel) channels, which leftward shifts GVs of BK channels around 50 mV in the absence of cytosolic Ca2+. LRRC55 protein is also t
Externí odkaz:
https://doaj.org/article/f74cb16156bf434ba0b173c4c4b7f9a2
Autor:
Ying-Ying Zhang, Xue Han, Ye Liu, Jian Chen, Lei Hua, Qian Ma, Yang-Yu-Xin Huang, Qiong-Yao Tang, Zhe Zhang
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197531 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0191749.].
Externí odkaz:
https://doaj.org/article/3f8a403231a0403d9d5da021a2b66daa
Autor:
Xiang-Ying Xu, Fei-Fei Zhang, Jun Gan, Mao-Yin Zhang, Zhong-Shan Shen, Qing Guo, Yue Teng, Jun-Wei Ji, Jun-Li Cao, Qiong-Yao Tang, Zhe Zhang
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience.
The transmembrane protein TMEM206 was recently identified as the molecular basis of the extracellular proton-activated Cl−channel (PAC), which plays an essential role in neuronal death in ischemia-reperfusion. The PAC channel is activated by extrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273a6bd2d59b6b8effeb5f70b588a3f9
https://pubmed.ncbi.nlm.nih.gov/36283831
https://pubmed.ncbi.nlm.nih.gov/36283831
Autor:
Nan Zhou, Hui Li, Jie Xu, Zhong-Shan Shen, Mingxi Tang, Xiao-Hui Wang, Wan-Xin Su, Masahiro Sokabe, Zhe Zhang, Qiong-Yao Tang
Publikováno v:
The Journal of biological chemistry. 298(9)
Atrial fibrillation is the most common sustained cardiac arrhythmia in humans. Current atrial fibrillation antiarrhythmic drugs have limited efficacy and carry the risk of ventricular proarrhythmia. GsMTx4, a mechanosensitive channel-selective inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76f81144be24882803cdfbc4af310b6
https://pubmed.ncbi.nlm.nih.gov/35933015
https://pubmed.ncbi.nlm.nih.gov/35933015
Autor:
Qi Zhang, Shun-Heng Gao, Zhong-Shan Shen, Yun Wang, Su-Wan Hu, Guang-Bing Duan, Ye Liu, Dan-Ya Zhong, Jing Liu, Meng-Han Sun, Xin Zhang, Tian-Yu Cao, Jun-Li Cao, Qiong-Yao Tang, Zhe Zhang
Publikováno v:
J Neurosci
Anxiety disorders are a series of mental disorders characterized by anxiety and fear, but the molecular basis of these disorders remains unclear. In the present study, we find that the globalSlack KOmale mice exhibit anxious behaviors, whereas the Sl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf74632fa5ab852eb99696a3f71977b
https://pubmed.ncbi.nlm.nih.gov/35197318
https://pubmed.ncbi.nlm.nih.gov/35197318