Safety, antitumor activity and biomarkers of sugemalimab in Chinese patients with advanced solid tumors or lymphomas: results from the first-in-human phase 1 trial

Autor: Jifang Gong, Junning Cao, Qingyuan Zhang, Nong Xu, Yanqiu Zhao, Baocai Xing, Zhanhui Miao, Yilong Wu, Hongming Pan, Quanli Gao, Xingya Li, Baorui Liu, Wei Li, Zhidong Pei, Hongqiang Xia, Qinzhou Qi, Hangjun Dai, Qingmei Shi, Jianxin Yang, Jin Li, Lin Shen

Publikováno v: Cancer Immunology, Immunotherapy. 71:1897-1908

Background This first-in-human phase 1 trial is to evaluate the safety, pharmacokinetics, preliminary efficacy, and biomarkers of sugemalimab, a full-length, fully human anti-PD-L1 monoclonal antibody, in Chinese patients with advanced malignancies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3546384a1f6680ae0fb92dc78fcc294a
https://doi.org/10.1007/s00262-021-03102-3

Insight into the evolution of the Solanaceae from the parental genomes of Petunia hybrida

Autor: Lukas A. Mueller, T. P. Robbins, Gonzalo H. Villarino, Trude Schwarzacher, Julia Weiss, Eva Nouri, Natalia Dudareva, Jan Zethof, Kevin M. Davies, Michiel Vandenbussche, Xiaodan Lv, Marcel Bucher, Philipp Franken, Nunzio D’Agostino, Massimo Delledonne, Mélanie K. Rich, Neil S. Mattson, Eric Lyons, Patrice Morel, Mattijs Bliek, Jennifer D. Hintzsche, Ronald Koes, Mitrick A. Johns, Laurie Grandont, Susan L. Urbanus, M. Eric Schranz, Qinzhou Qi, Michael C. Schatz, Enrico Martinoia, Laure Bapaume, Robert C. Schuurink, Aureliano Bombarely, Didier Reinhardt, Rémy Bruggmann, Katja R. Richert-Pöggeler, Mario Pezzotti, Maaike R. Boersma, Michel Moser, J. S. Heslop-Harrison, Uwe Druege, Diwa Malla, Kitty Vijverberg, Lorenzo Borghi, Ryan M. Warner, Haibao Tang, Avichai Moshe Amrad, Kees Spelt, Thomas L. Sims, Valentina Passeri, Francesca Quattrocchio, Manzhu Bao, Joëlle K. Muhlemann, Marcos Egea-Cortines, Cornelius S. Barry, Zhen Yue, Noe Fernandez-Pozo, Cris Kuhlemeier

Publikováno v: Nature Plants, 2:16074
Nature Plants, 2, pp. 16074
Nature Plants
Nature Plants, Nature Publishing Group, 2016, 2 (6), ⟨10.1038/nplants.2016.74⟩
Nature Plants, 2, 16074
Nature Plants, 2
Bombarely, Aureliano; Moser, Michel; Amrad, Avichai Moshe; Bao, Manzhu; Bapaume, Laure; Barry, Cornelius S.; Bliek, Mattijs; Boersma, Maaike R.; Borghi, Lorenzo; Bruggmann, Rémy; Bucher, Marcel; D'Agostino, Nunzio; Davies, Kevin; Druege, Uwe; Dudareva, Natalia; Egea-Cortines, Marcos; Delledonne, Massimo; Fernandez-Pozo, Noe; Franken, Philipp; Grandont, Laurie; ... (2016). Insight into the evolution of the Solanaceae from the parental genomes of Petunia hybrida. Nature Plants, 2(6), p. 16074. Nature Publishing Group 10.1038/nplants.2016.74
Nature plants
Nature Plants, 2016, 2 (6), ⟨10.1038/nplants.2016.74⟩
Nature Plants 2 (2016)

Petunia hybrida is a popular bedding plant that has a long history as a genetic model system. We report the whole-genome sequencing and assembly of inbred derivatives of its two wild parents, P. axillaris N and P. inflata S6. The assemblies include 9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db670f37fd99c9c8649a066ad85cfecc
https://dare.uva.nl/personal/pure/en/publications/insight-into-the-evolution-of-the-solanaceae-from-the-parental-genomes-of-petunia-hybrida(4617299f-d154-4e6d-876c-290435a60663).html

Preliminary results from subsets of patients (pts) with advanced gastric cancer (GC) and esophageal carcinoma (EC) in a dose-escalation/expansion study of BGB-A317, an anti-PD-1 monoclonal antibody (mAb)

Autor: Michael Millward, Hui K Gan, Yee Chao, Ben Markman, A. Kang, Jayesh Desai, Victoria Atkinson, Amanda R. Townsend, Andrew X. Zhu, Mark Voskoboynik, J. Song, Qinzhou Qi, Sanjeev Deva

Publikováno v: Annals of Oncology. 28:v129

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8917d3b5463ada491fbc8f0c39a6bcd3
https://doi.org/10.1093/annonc/mdx367.021