Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Qinmi Wang"'
Publikováno v:
Chinese Journal of Chemistry. 15:84-89
We have used quantum mechanical method to study the transition states(TSs) of uridine phosphorolysis reaction. Comparing the four different reaction pathways and the five transition states obtained, we conclude that enzymatic uridine phosphorolysis t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::815cf5e98f4b6b32942c543a2646b368
https://doi.org/10.1002/cjoc.19970150115
https://doi.org/10.1002/cjoc.19970150115
Publikováno v:
CNS Drug Reviews. 5:125-144
Benzodiazepine (BZ) binding site ligands are important central nervous system (CNS) drugs. Their numbers and our knowledge of how they interact with the BZ-binding site of GABAA receptors are both rapidly expanding. The GABAA receptor is a member of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c10a60a0cc64d30589789b850a4801c
https://doi.org/10.1111/j.1527-3458.1999.tb00094.x
https://doi.org/10.1111/j.1527-3458.1999.tb00094.x
Autor:
Andrea E. DeBarber, Dennis R. Koop, Hong Liu, Margit Spatzenegger, Qinmi Wang, James R. Halpert
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 304:477-487
Human CYP2B6 and CYP2E1 were used to investigate the extent to which differential substrate selectivities between cytochrome P450 subfamilies reflect differences in active-site residues as opposed to distinct arrangement of the backbone of the enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec075f360ad4281455566666fa06a515
https://doi.org/10.1124/jpet.102.043323
https://doi.org/10.1124/jpet.102.043323
Publikováno v:
Archives of Biochemistry and Biophysics. 394:21-28
At least two substitutions were made at each of five amino acid residues in rat cytochrome P450 2B1 that align to residues of known importance in other P450s. The mutants were histidine tagged for purification from Escherichia coli, and the proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7be07d04ff9ff0355c89e376e968e2d
https://doi.org/10.1006/abbi.2001.2504
https://doi.org/10.1006/abbi.2001.2504
Autor:
You-Ai He, Fabienne Roussel, Qinmi Wang, Tammy L. Domanski, James R. Halpert, Kishore K. Khan
Publikováno v:
Biochemistry. 40:10150-10160
Phenylalanine and/or tryptophan scanning mutagenesis was performed at 15 sites within CYP3A4 proposed to be involved in substrate specificity or cooperativity. The sites were chosen on the basis of previous studies or from a comparison with the struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149a68f3537f328a82952fa11937d3d8
https://doi.org/10.1021/bi010758a
https://doi.org/10.1021/bi010758a
Autor:
Huifen Faye Wang, Qinmi Wang, Grazyna D. Szklarz, Tammy L. Domanski, Linlong Xue, James R. Halpert, Maria Almira Correia
Publikováno v:
Chemical Research in Toxicology. 14:483-491
The major human liver drug-metabolizing cytochrome P450 enzymes P450 3A4 and P450 3A5 share >85% amino acid sequence identity yet exhibit different regioselectivity toward aflatoxin B(1) (AFB(1)) biotransformation [Gillam et al. (1995) Arch. Biochem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58db40bb94e4aa7e721a9b54e780b7b
https://doi.org/10.1021/tx000218z
https://doi.org/10.1021/tx000218z
Publikováno v:
Biophysical Chemistry. 75:129-139
The electronic structure of the whole molecule of acidic phospholipase A2 (PLA2) from the venom of Agkistrodon halys pallas (A. halys pallas) has been calculated using the extended negative factor counting (ENFC) method in which dimers were calculate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586e14627b9a1cbcf38e962f0cb0b50e
https://doi.org/10.1016/s0301-4622(98)00200-2
https://doi.org/10.1016/s0301-4622(98)00200-2
Publikováno v:
International Journal of Quantum Chemistry. 70:515-525
The acylation process in the acetylcholinesterase (AChE)-catalyzed hydrolysis of the neurotransmitter, acetylcholine (ACh), has been determined with the semiempirical quantum chemical calculation method AM1 using the model molecules extracted from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::149bafb7b157d4da3d231f9ae0ec04e1
https://doi.org/10.1002/(sici)1097-461x(1998)70:3<515::aid-qua7>3.0.co
https://doi.org/10.1002/(sici)1097-461x(1998)70:3<515::aid-qua7>3.0.co
Publikováno v:
Journal of Medicinal Chemistry. 40:3085-3090
The mechanism of inhibition of peptidyl inhibitors with thrombin was studied using molecular modeling, molecular mechanics, and CoMFA statistical analysis. A new procedure for the elucidation of binding conformations, BCSPL, is described and was empl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be748296372aa390d1b51f3f91ba4e4a
https://doi.org/10.1021/jm960309m
https://doi.org/10.1021/jm960309m
Autor:
James R. Halpert, Qinmi Wang
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 30(1)
Understanding the basis of the substrate specificity of cytochrome P450 2B6 (CYP2B6) is important for determining the role of this enzyme in drug metabolism and for predicting new substrates. Pharmacophores were generated for 16 structurally diverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d051797030f1afb67b54a0037e2c5b64
https://pubmed.ncbi.nlm.nih.gov/11744616
https://pubmed.ncbi.nlm.nih.gov/11744616