Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Qinhui Rao"'
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2623
Cryo-electron microscopy (cryo-EM) has become the mainstream technique for studying macromolecular structures. Determining the structures of protein complexes is more accessible to structural biologists than ever before. Nevertheless, obtaining high-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ad8e3b595555946d187241e50214103
https://pubmed.ncbi.nlm.nih.gov/36602691
https://pubmed.ncbi.nlm.nih.gov/36602691
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629574
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0cf8b47b6c74a803aba2fd7841d6937
https://doi.org/10.1007/978-1-0716-2958-1_16
https://doi.org/10.1007/978-1-0716-2958-1_16
Autor:
Jonathon Howard, Pengxin Chai, Fangheng Hu, Yin-Wei Kuo, Yue Wang, Long Han, Yuchen Yang, Renbin Yang, Qinhui Rao, Kai Zhang
Publikováno v:
Nature Structural & Molecular Biology
Thousands of outer-arm dyneins (OADs) are arrayed in the axoneme to drive a rhythmic ciliary beat. Coordination among multiple OADs is essential for generating mechanical forces to bend microtubule doublets (MTDs). Using electron microscopy, we deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27357ea41ece455d7dc03ee4898c389a
https://doi.org/10.1038/s41594-021-00656-9
https://doi.org/10.1038/s41594-021-00656-9
Publikováno v:
Genome Instability & Disease. 2:211-224
DNA damage can be introduced by intrinsic or extrinsic stimuli and threaten the transmission of genetic information and ultimately, survival. Eukaryotes have evolved a sophisticated mechanism, DNA damage response (DDR), to counteract this threat pose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::731aca60c8a57c8c5f2ea539f4ecb0a5
https://doi.org/10.1007/s42764-021-00045-y
https://doi.org/10.1007/s42764-021-00045-y
Publikováno v:
Nature Structural & Molecular Biology. 30:564-564
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::642de7e2fdc203cf57e8c74c8436031c
https://doi.org/10.1038/s41594-023-00961-5
https://doi.org/10.1038/s41594-023-00961-5
Accurately regulated ciliary beating in time and space is critical for diverse cellular activities, which impact the survival and development of nearly all eukaryotic species. An essential beating regulator is the conserved central apparatus (CA) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b145dc4f8f0dee1f887fe5b9a6d4a5
https://doi.org/10.1101/2022.01.23.477438
https://doi.org/10.1101/2022.01.23.477438
Publikováno v:
Journal of Structural Biology. 214:107897
Revealing high-resolution structures of microtubule-associated proteins (MAPs) is critical for understanding their fundamental roles in various cellular activities, such as cell motility and intracellular cargo transport. Nevertheless, large flexible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4b16875506a3fe2d56a171a5a78724
https://doi.org/10.1016/j.jsb.2022.107897
https://doi.org/10.1016/j.jsb.2022.107897
Autor:
Renbin Yang, Qinhui Rao, Yue Wang, Jonathon Howard, Long Han, Kai Zhang, Yuchen Yang, Pengxin Chai, Yin-Wei Kuo
Publikováno v:
The FASEB Journal. 35
Thousands of outer-arm dyneins (OADs) are arrayed in the axoneme to drive a rhythmic ciliary beat. Using electron microscopy, we determined the structure of OAD array bound to microtubule doublets (MTDs) in near-atomic details and illuminate how OADs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79bebae499e8f60849a6d46b748aa5ab
https://doi.org/10.1096/fasebj.2021.35.s1.03099
https://doi.org/10.1096/fasebj.2021.35.s1.03099
Autor:
Qinhui Rao, Mengjie Liu, Yuan Tian, Zihan Wu, Yuhan Hao, Lei Song, Zhaoyu Qin, Chen Ding, Hong-Wei Wang, Jiawei Wang, Yanhui Xu
Publikováno v:
Cell research. 28(2)
ATR (ataxia telangiectasia-mutated and Rad3-related) protein kinase and ATRIP (ATR-interacting protein) form a complex and play a critical role in response to replication stress and DNA damage. Here, we determined the cryo-electron microscopy (EM) st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209a2de6f9d634611558e67e2b7c55c4
https://pubmed.ncbi.nlm.nih.gov/29271416
https://pubmed.ncbi.nlm.nih.gov/29271416
Autor:
Ze Li, Yujiang Geno Shi, Yanhui Xu, Mengjie Liu, Lulu Hu, Qinhui Rao, Jiayu Zhu, Ping Wang, Jingdong Cheng, Wei Gong
Publikováno v:
Cell. 155:1545-1555
SummaryTET proteins oxidize 5-methylcytosine (5mC) on DNA and play important roles in various biological processes. Mutations of TET2 are frequently observed in myeloid malignance. Here, we present the crystal structure of human TET2 bound to methyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c856d8b337e0ccfbf0a652914ed56218
https://doi.org/10.1016/j.cell.2013.11.020
https://doi.org/10.1016/j.cell.2013.11.020