Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Qinheng Zheng"'
Autor:
Leopold Garnar-Wortzel, Timothy R. Bishop, Seiya Kitamura, Natalia Milosevich, Joshua N. Asiaban, Xiaoyu Zhang, Qinheng Zheng, Emily Chen, Anissa R. Ramos, Christopher J. Ackerman, Eric N. Hampton, Arnab K. Chatterjee, Travis S. Young, Mitchell V. Hull, K. Barry Sharpless, Benjamin F. Cravatt, Dennis W. Wolan, Michael A. Erb
Publikováno v:
ACS Central Science, Vol 7, Iss 5, Pp 815-830 (2021)
Externí odkaz:
https://doaj.org/article/097fa2b7ad3f4a1fa4c7766ad3a5dcd3
Autor:
Qingsong Wu, Qi Xue, Ji Li, Qinheng Zheng, Xinlu Zhao, Wannan Li, Shiming Sun, Wanxing Sha, Yang Yang, Yi Yang, Jie P. Li
Publikováno v:
CCS Chemistry. :1-13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02ae542997d4bf7bb867fcb5ea5c22de
https://doi.org/10.31635/ccschem.022.202202386
https://doi.org/10.31635/ccschem.022.202202386
Publikováno v:
Journal of Medicinal Chemistry. 65:3119-3122
Since its discovery as the first human oncogene in 1983, the small GTPase KRAS has been a major target of cancer drug discovery. The paper reported in this issue describes a long-awaited small molecule drug candidate of the oncogenic KRAS (G12D) muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8cb65f302015195f4c2542c49f69a3
https://doi.org/10.1021/acs.jmedchem.2c00099
https://doi.org/10.1021/acs.jmedchem.2c00099
Autor:
Jie Li, Qingsong Wu, Xue Qi, Ji Li, Qinheng Zheng, Xinlu Zhao, Wannan Li, Shiming Sun, Wanxing Sha, Yang Yang, Yi Yang
Cysteine (Cys)-specific bioconjugation has found wide application in the synthesis of protein conjugates, particularly for the functionalization of antibody. Here, through direct assessment on protein substrate, we report the discovery of trans-styry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abe5c25d599ab9ed21152c3b9b7fa1b4
https://doi.org/10.26434/chemrxiv-2022-hlfkq
https://doi.org/10.26434/chemrxiv-2022-hlfkq
Autor:
Hongtao Xu, K. Barry Sharpless, Peng Wu, Hua Wang, Huan Xiong, Nan Wang, Wen-Ge Han Du, Yuang Gu, Qinheng Zheng, Guang Yang, Louis Noodleman
Publikováno v:
Journal of the American Chemical Society. 143:3753-3763
The lack of efficient [18F]fluorination processes and target-specific organofluorine chemotypes remains the major challenge of fluorine-18 positron emission tomography (PET). We report here an ultrafast isotopic exchange method for the radiosynthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a42f560b9bbce33739302738d5c40ef5
https://doi.org/10.1021/jacs.0c09306
https://doi.org/10.1021/jacs.0c09306
Autor:
Seiya Kitamura, Qinheng Zheng, Nicholas Dillon, Angelo Solania, Jordan L. Woehl, Miyako Kotaniguchi, John R. Cappiello, Shinichi Kitamura, Dennis W. Wolan, Victor Nizet, Mitchell V. Hull, Emily I. Chen, K. Barry Sharpless
Publikováno v:
J Am Chem Soc
Optimization of small-molecule probes or drugs is a synthetically lengthy, challenging, and resource-intensive process. Lack of automation and reliance on skilled medicinal chemists is cumbersome in both academic and industrial settings. Here, we dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf71ebb2630949782c503b6d31383a09
https://doi.org/10.1021/jacs.9b13652
https://doi.org/10.1021/jacs.9b13652
Autor:
Jiajia Dong, Suhua Li, Andrew S. Barrow, Qinheng Zheng, John E. Moses, Christopher J. Smedley
Publikováno v:
Chemical Society Reviews. 48:4731-4758
SuFEx (Sulfur Fluoride Exchange) is a modular, next generation family of click reactions, geared towards the rapid and reliable assembly of functional molecules. This review discusses the growing number of applications of SuFEx, which can be found in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0843e63ecbd9dd31c0ca91cb3c9cb44b
https://doi.org/10.1039/c8cs00960k
https://doi.org/10.1039/c8cs00960k
Autor:
Qinheng, Zheng, Hongtao, Xu, Hua, Wang, Wen-Ge Han, Du, Nan, Wang, Huan, Xiong, Yuang, Gu, Louis, Noodleman, K Barry, Sharpless, Guang, Yang, Peng, Wu
Publikováno v:
Journal of the American Chemical Society. 143(10)
The lack of efficient [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2454848b94932e4314e92a3481d92aa4
https://pubmed.ncbi.nlm.nih.gov/33785891
https://pubmed.ncbi.nlm.nih.gov/33785891
Autor:
Benjamin F. Cravatt, Qinheng Zheng, Leopold Garnar-Wortzel, Eric N. Hampton, Seiya Kitamura, Anissa R. Ramos, Michael A. Erb, Joshua N. Asiaban, Natalia Milosevich, K. Barry Sharpless, Xiaoyu Zhang, Emily Chen, Travis S. Young, Timothy R. Bishop, Arnab K. Chatterjee, Christopher J. Ackerman, Dennis W. Wolan, Mitchell V. Hull
Transcriptional co-regulators, which mediate chromatin-dependent transcriptional signaling, represent tractable targets to modulate tumorigenic gene expression programs with small molecules. Genetic loss-of-function studies have recently implicated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5d4cf4198bd8dc8c44f5702413eca61
https://doi.org/10.1101/2020.12.01.406694
https://doi.org/10.1101/2020.12.01.406694
Autor:
Miyako Kotaniguchi, angelo solan, Seiya Kitamura, Jordan L. Woehl, Victor Nizet, Mitchell V. Hull, Emily I. Chen, Dennis W. Wolan, Nicholas Dillon, K. Barry Sharpless, Qinheng Zheng, Shinichi Kitamura
Optimization of small-molecule probes or drugs is a lengthy, challenging and resource-intensive process. Lack of automation and reliance on skilled medicinal chemists is cumbersome in both academic and industrial settings. Here, we demonstrate a high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469b8f6284e639ea4f5ac496d31efff6
https://doi.org/10.26434/chemrxiv.11385906
https://doi.org/10.26434/chemrxiv.11385906