Výsledky vyhledávání - "Qingzheng Zhao"

A tritherapy combination of a fusion protein vaccine with immune‐modulating doses of sequential chemotherapies in an optimized regimen completely eradicates large tumors in mice

Autor: Mengjiao Chang, Qingzheng Zhao, Xinlai Qian, Jianfeng Cui, Xinxin Song, Qiliang Cai, Wenzhong Guo, Linan Yi

Publikováno v: International Journal of Cancer. 128:1129-1138

Tumor-induced immunosuppression plays a critical role in both impeding tumor-specific immune responses and limiting the effects of cancer immunotherapy. Analyses of regulatory cells recruited during the growth of the E7-expressing tumor, TC-1, reveal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb08d476946876e8542a49cffe49c453
https://doi.org/10.1002/ijc.25451

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A novel therapeutic fusion protein vaccine by two different families of heat shock proteins linked with HPV16 E7 generates potent antitumor immunity and antiangiogenesis

Autor: Jietao Song, Qingzheng Zhao, Zhiyuan Zhang, Dongxia Ye, Xinxin Song, Xinhua Zhao, Linan Yi, Bo Liu

Publikováno v: Vaccine. 26:1387-1396

Human papillomaviruses (HPV), particularly HPV16, is considered a necessary cause of cervical and oral cancer. Thus, the development of a therapeutic vaccine against HPV is important for the control of cervical cancer. However, therapeutic vaccinatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8286b91dfb42d5322dfa39b25dfe8f
https://doi.org/10.1016/j.vaccine.2007.12.034

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Prophylactic, therapeutic and anti-metastatic effects of an HPV-16mE6Δ/mE7/TBhsp70Δ fusion protein vaccine in an animal model

Autor: Ke Chen, Qingzheng Zhao, Jietao Song, Yuanzhi Lu, Qiao Liu, Xinlai Qian

Publikováno v: Immunology Letters. 102:191-201

Human papillomaviruses (HPVs), particularly HPV-16, are not only causally linked to cervical cancers but also play an important role in the development of other cancers. The oncoproteins, E6 and E7, are consistently coexpressed in the majority of HPV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751de0820871b91d7b7bbcb99b08b8a9
https://doi.org/10.1016/j.imlet.2005.09.004

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Inhibitory effect of the adenovirus type 5 E1A protein expressed in the yeast system on the human tumor cell growth

Autor: Xin Gao, Yanchun Li, Xiaoshan Zhou, Xinlai Qian, Yuying Liu, Yewei Ma, Qingzheng Zhao, Zheng Wang, Jun Yang

Publikováno v: Science Bulletin. 48:687-691

Adenovirus 5 type E1A as a tumor suppressor gene can inhibit tumor growth and enhance the sensitivity of chemotherapy and radiotherapy. E1A have the ability to integrate into the host genome, resulting in long-time expression that induces Rb gene ina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27e2ebb9c58122c0315de4d222647a35
https://doi.org/10.1007/bf03325656

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Specific myeloprotection via multidrug resistance 1 gene controlled by aminopeptidase N myeloid promoter

Autor: Yanchun Li, Jun Yang, Qingzheng Zhao, Yewei Ma, Yuying Liu, Xiaoshan Zhou, Li-bo Liang, Zheng Wang

Publikováno v: Chinese Science Bulletin. 47:1650-1653

In the treatment of tumor patients introduction of multidrug resistance genes into hematopoietic cells has been reported as an approach for reducing myelotoxicity created by antitumor drugs. However, the nonspecific expression of the genes can also i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f85a27debbf3e1e8c454199381b552d3
https://doi.org/10.1007/bf03184116

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Inhibitory effect of the HPV-16mE6δ/mE7/TBhsp70δ vaccine on oral squamous cell carcinoma

Autor: Lei Zhang, Qian Jiang, Qingzheng Zhao, Xiao-jian Zhou, Kui-Jie Wei, Lai-ping Zhong, Dongxia Ye, Zhiyuan Zhang

Publikováno v: The American journal of the medical sciences. 345(5)

Aim To evaluate the inhibitory effect of a recombinant human papillomavirus (HPV) fusion protein vaccine on oral squamous cell carcinoma (OSCC). Materials and Methods An animal model of OSCC was established using human peripheral blood lymphocyte rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a9a53f4cf0966549969b5fff7a1680
https://pubmed.ncbi.nlm.nih.gov/22885621

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PERP gene therapy attenuates lung cancer xenograft via inducing apoptosis and suppressing VEGF

Autor: Qingzheng Zhao, Zhongwu Li, Yiqiang Liu, Ke Chen, Zhaoyang Luo

Publikováno v: Cancer biologytherapy. 12(12)

Inducing apoptosis is an attractive antitumor strategy. PERP is an apoptosis-associated target of p53, and its activation alone is sufficient to induce apoptotic pathway leading to cell death. We have previously demonstrated that overexpression of PE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd365e16e342bc88e08eeb0449a622a5
https://pubmed.ncbi.nlm.nih.gov/22236877

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[The anti-lung cancer activity of a modified HPV 16 type mE6Δ/mE7 fusion protein based vaccine in an experimental animal model]

Autor: Xiaoshan, Zhou, Qingzheng, Zhao, Xinlai, Qian, Chunlei, Xu, Yuanzhi, Lu

Publikováno v: Zhongguo fei ai za zhi = Chinese journal of lung cancer. 7(5)

To investigate the outgrowth inhibition of the HPV16-positive murine lung tumor induced by a modified HPV16 mE6Δ/mE7 recombinant fusion protein vaccine in vivo and provide a new clue for the further immunotherapy.For prophylactic experiments, C57BL/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e91a481ac03de9baaaac78eb434c6442
https://pubmed.ncbi.nlm.nih.gov/21244786

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