BM-MSCs display altered gene expression profiles in B-cell acute lymphoblastic leukemia niches and exert pro-proliferative effects via overexpression of IFI6

Autor: Chengyun Pan, Tianzhen Hu, Ping Liu, Dan Ma, Shuyun Cao, Qin Shang, Luxin Zhang, Qingzhen Chen, Qin Fang, Jishi Wang

Publikováno v: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-19 (2023)

Abstract Background The tumor microenvironment (TME) is a supportive environment responsible for promoting the growth and proliferation of tumor cells. Current studies have revealed that the bone marrow mesenchymal stem cells (BM-MSCs), a type of cru

Externí odkaz: https://doaj.org/article/023efc73c8bb4aa498e5f2af85df648c

Mesenchymal Stem Cells With Cancer-Associated Fibroblast-Like Phenotype Stimulate SDF-1/CXCR4 Axis to Enhance the Growth and Invasion of B-Cell Acute Lymphoblastic Leukemia Cells Through Cell-to-Cell Communication

Autor: Chengyun Pan, Qin Fang, Ping Liu, Dan Ma, Shuyun Cao, Luxin Zhang, Qingzhen Chen, Tianzhen Hu, Jishi Wang

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Background: Bone marrow mesenchymal stem cells (BM-MSCs) are the stromal cells in the leukemia microenvironment, and can obtain cancer-associated fibroblast (CAF)-like phenotype under certain conditions to further promote leukemia progression. Howeve

Externí odkaz: https://doaj.org/article/385ff1f5c701493490129043c16ff975

Upregulation of signal transducer and activator of transcription 4 promotes osteoblast activity by activating AMP-activated protein kinase based on cationic liposome transfection

Autor: Gang Wang, Qinsheng Wang, Tao Jiang, Zhenming Zeng, Zhen Shen, Min Shao, Qingzhen Chen

Publikováno v: Materials Express. 10:1836-1845

Activation of Protein Kinase AMP-Activated Catalytic Subunit Alpha (AMPKα) is an important regulatory pathway for osteogenic differentiation. STAT4 acts as a transcriptional activity factor to regulate the transcription of many genes and is potentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4f0fd7cd4981b6251924d2d24288454
https://doi.org/10.1166/mex.2020.1822

Analysis of Underwater Robot Structure Based on Fluent

Autor: Fulin Yu, Qin Sun, Qingzhen Chen, Zhiguang Guan

Publikováno v: Proceedings of the 11th International Conference on Computer Engineering and Networks ISBN: 9789811665530
Proceedings of the 11th International Conference on Computer Engineering and Networks

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee6b7ed29a6e08986c39832b2f1ea793
https://doi.org/10.1007/978-981-16-6554-7_130

RNA Synthesis by DNA Methyltransferase 1 siRNA Transfection with Cationic Liposomes into Osteoblastic Progenitor Cells Based on SiO² Nanomagnetic Beads for Proliferation and Differentiation

Autor: Qingzhen, Chen, Tao, Jiang, Qinshen, Wang, Yongqing, Huang, Min, Shao

Publikováno v: Journal of nanoscience and nanotechnology. 20(10)

DNA methylation regulated gene expression is important for osteoblast proliferation and differentiation during bone remodeling and its deregulation leads to the development of osteoporosis. DNA methyltransferase 1 (DNMT1) is an important regulator of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::adbf701f7119b23ef1fe8c911f524eb0
https://pubmed.ncbi.nlm.nih.gov/32384955