Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Qingyu Lang"'
Publikováno v:
Economic Research-Ekonomska Istraživanja. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b448c5c897e5d8e3f1446317e269d6a
https://doi.org/10.1080/1331677x.2023.2205923
https://doi.org/10.1080/1331677x.2023.2205923
Publikováno v:
European Journal of Medicinal Chemistry. 89:310-319
Aurora B is a serine/threonine kinase that has a key role in mitosis and is overexpressed in cancer cells. Aberrations in Aurora B are highly correlated with tumorigenesis and cancer development, so many studies have focused on the development of Aur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99db4da7108da9b5a8cf6c098ab8b17
https://doi.org/10.1016/j.ejmech.2014.10.044
https://doi.org/10.1016/j.ejmech.2014.10.044
Autor:
Yifeng Zhang, Bo Wan, Mei Zhou, Zhishun Zhang, Haoxing Zhang, Qingyu Lang, Fang Xie, Long Yu, Qiang Huang
Publikováno v:
European Journal of Pharmaceutical Sciences. 46:388-396
In human, Aurora B is a chromosomal passenger protein that induces phosphorylation of histone and involves in spindle checkpoint and cytokinesis. Aberrant expression of Aurora B has been shown to correlate with genetic instability and carcinogenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7786afde09cd96e1c4d1f101a246cc68
https://doi.org/10.1016/j.ejps.2012.03.002
https://doi.org/10.1016/j.ejps.2012.03.002
Publikováno v:
Molecular Biology Reports. 37:1577-1583
The Aurora kinases play a critical role in mitosis and have been suggested as promising targets for cancer therapy due to their frequent overexpression in a variety of tumors. Compared with established inhibitors of cell division such as the anti-tub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1a3ddaa6ab96b77e0303f5aaccfc76
https://doi.org/10.1007/s11033-009-9562-y
https://doi.org/10.1007/s11033-009-9562-y
Publikováno v:
Molecular Biology Reports. 36:697-703
Members of the Ly-6 (Lymphocyte Antigen 6) protein family share one or several repeat units of the LU domain that is defined by a distinct disulfide bonding pattern between 8 or 10 cysteine residues. Here we report the cloning and characterization of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c37c123bfd6a0d1326b9ef39797586
https://doi.org/10.1007/s11033-008-9231-6
https://doi.org/10.1007/s11033-008-9231-6
Publikováno v:
Molecular Biology Reports. 35:351-359
Glycerophosphodiester phosphodiesterase (GDPD) catalyzes the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol. GDPD5 has been reported in Mus musculus and Gallus gallus, but not in Homo sapiens. Here we report the cloni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4663efcdb910c98202249dab753ba0d9
https://doi.org/10.1007/s11033-007-9093-3
https://doi.org/10.1007/s11033-007-9093-3
Publikováno v:
International Journal of Molecular Sciences; Volume 8; Issue 5; Pages: 433-444
International Journal of Molecular Sciences, Vol 8, Iss 5, Pp 433-444 (2007)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 8, Iss 5, Pp 433-444 (2007)
International Journal of Molecular Sciences
The glycine-N-acyltransferase (GLYAT) is well known to be involved in the detoxification of endogenous and exogenous xenobiotic acyl-CoA’s in mammals. Unfortunately, the knowledge about the gene encoding GLYAT is very limited. Here we report a nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d5b03a0c273a1d5c0cde0ef54cc8c8
https://doi.org/10.3390/i8050433
https://doi.org/10.3390/i8050433
Autor:
Pratima Bansal-Pakala, David B. Duignan, QingYu Lang, Lian Rundell, Eric C. Breinlinger, Jianfei Wang, Scott W. Mittelstadt, Yang Zhang, Annette Schwartz, Jiakang Sun, Maria A. Argiriadi, P. Honore, Jeremy J. Edmunds, Dawn M. George
Publikováno v:
Journal of medicinal chemistry. 58(1)
We previously demonstrated that selective inhibition of protein kinase Cθ (PKCθ) with triazinone 1 resulted in dose-dependent reduction of paw swelling in a mouse model of arthritis.1,2 However, a high concentration was required for efficacy, thus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb3afcba5aae2b6746c954032c8e149
https://pubmed.ncbi.nlm.nih.gov/25254961
https://pubmed.ncbi.nlm.nih.gov/25254961
Autor:
Lian Rundell, Dominique Potin, Martine Barth, Yang Zhang, Jianfei Wang, Pratima Bansal-Pakala, Michael Friedman, Maria A. Argiriadi, QingYu Lang, David B. Duignan, Eric C. Breinlinger, Scott W. Mittelstadt, Jeremy J. Edmunds, Dawn M. George, P. Honore
Publikováno v:
Journal of medicinal chemistry. 58(1)
Protein kinase Cθ (PKCθ) regulates a key step in the activation of T cells. On the basis of its mechanism of action, inhibition of this kinase is hypothesized to serve as an effective therapy for autoimmune diseases such as rheumatoid arthritis (RA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc66c8e424479ef51abc03dde2fafe3
https://pubmed.ncbi.nlm.nih.gov/25000588
https://pubmed.ncbi.nlm.nih.gov/25000588
Publikováno v:
Biotechnology letters. 35(6)
Aurora kinases, frequently detected to be over-expressing in human tumors, regulate many essential events during mitosis progression and have been regarded as potentially important targets for cancer therapy. S39 is a novel potent inhibitor of Aurora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8287c0f523f0846ee3fe711abd3a57
https://pubmed.ncbi.nlm.nih.gov/23443212
https://pubmed.ncbi.nlm.nih.gov/23443212